| Interacting proteins: Q9NRY4 and P12931 |
Pubmed |
SVM Score :0.0 |
| Src mediated tyrosyl phosphorylation of p190RhoGAP correlated with changes in the ability of p190RhoGAP to interact with Rho ; , suggesting that Src regulates Rho ; function via p190RhoGAP . ^^^ |
|
| Interacting proteins: Q9NRY4 and P12931 |
Pubmed |
SVM Score :0.0 |
| Analyses of the members of the HRG stimulated complex revealed that RAFTK is associated with p 190 RhoGAP ( p 190 ) , RasGAP and ErbB 2 , and plays an essential role in mediating the tyrosine phosphorylation of p 190 by Src . ^^^ |
|
| Interacting proteins: Q9NRY4 and P12931 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of the p 190 RhoGAP N terminal domain by c Src results in a loss of GTP binding activity . p 190 RhoGAP is a multi domain protein that is thought to regulate actin cytoskeleton dynamics . ^^^ |
|
| Interacting proteins: Q9NRY4 and P12931 |
Pubmed |
SVM Score :0.0 |
| Additionally , early integrin signaling induces activation and tyrosine phosphorylation of p190RhoGAP via a mechanism that requires c Src . ^^^ |
|
| Interacting proteins: Q9NRY4 and P12931 |
Pubmed |
SVM Score :0.0 |
| Correlating with the ability of c Src variants to potentiate or inhibit EGF dependent DNA synthesis is the phosphotyrosine content of multiple cellular proteins , including p 190 RhoGAP , a protein thought to regulate growth factor induced actin cytoskeleton remodeling by modulating the activity of the small GTP binding protein , Rho . ^^^ |
|
| Interacting proteins: Q9NRY4 and P12931 |
Pubmed |
SVM Score :0.0 |
| In the 10T model , preferred substrates of c Src are almost exclusively comprised of those molecules that associate with the actin cytoskeleton or with focal adhesions , such as cortactin , p190RhoGAP , and p130CAS , while preferred substrates of the EGF receptor include the receptor itself , SHC , phospholipase C gamma and p62DOK . ^^^ |
|
| Interacting proteins: Q9NRY4 and P12931 |
Pubmed |
SVM Score :0.0 |
| Phosphotyrosine ( p Tyr ) dependent and independent mechanisms of p 190 RhoGAP p 120 RasGAP interaction : Tyr 1105 of p 190 , a substrate for c Src , is the sole p Tyr mediator of complex formation . p 190 RhoGAP is a 190 kDa protein that stably associates with p 120 RasGAP and regulates actin dynamics through members of the Rho family of small GTPases . ^^^ |
|
| Interacting proteins: Q9NRY4 and P12931 |
Pubmed |
SVM Score :0.0 |
| Here , we have examined in detail the effects of a temperature dependent 5 Src protein on the regulation of p 190 RhoGAP , a GTPase activating protein ( GAP ) that has been implicated in disruption of the organised actin cytoskeleton , and addressed the dependence of 5 Src induced stress fibre loss on inhibition of Rho activity . ^^^ |
|
| Interacting proteins: Q9NRY4 and P12931 |
Pubmed |
SVM Score :0.0 |
| The first complex , including RasGAP , p 190 RhoGAP and p 62 , was previously characterized in murine fibroblasts overexpressing c Src or transformed by 5 Src and has been correlated with cytoskeleton remodelling . ^^^ |
|
| Interacting proteins: Q9NRY4 and P12931 |
Pubmed |
SVM Score :0.0 |
| Here we identify the potent Rho regulatory protein , p 190 RhoGAP ( GTPase activating protein ) , as the principal Src substrate detected in the developing and mature nervous system . ^^^ Together with the fact that mice lacking neural adhesion molecules or Src kinases also exhibit defects in axon outgrowth , guidance and fasciculation , our results suggest that p 190 RhoGAP mediates a Src dependent adhesion signal for neuritogenesis to the actin cytoskeleton through the Rho GTPase . . ^^^ |
|
| Interacting proteins: Q9NRY4 and P12931 |
Pubmed |
SVM Score :0.0 |
| The clustering of beta ( 2 ) integrins also induced a time dependent increase in GDP bound to RhoA , which correlated with beta ( 2 ) integrin induced activation of p190RHOGAP : The activation of p190RhoGAP was completely blocked by [ 4 amino 5 ( 4 methylphenyl ) 7 ( t butyl ) pyrazolo [ 3 , 4 d ] pyrimidine ] ( PP 1 ) , a selective inhibitor of Src family tyrosine kinases . ^^^ Thus , in neutrophils , beta ( 2 ) integrin induced activation of p190RhoGAP requires a signal from a Src family tyrosine kinase , but it does not occur via the signaling pathway responsible for activation of RHOA : . ^^^ |
|
| Interacting proteins: Q9NRY4 and P12931 |
Pubmed |
SVM Score :0.0 |
| In addition , we show that tyrosine phosphorylation of p190RhoGAP is increased upon 12 O tetradecanoylphorbol 13 acetate stimulation , directly linking Src activation to a decrease in RhoA activity . ^^^ |
|
| Interacting proteins: Q9NRY4 and P12931 |
Pubmed |
SVM Score :0.0 |
| Phosphorylated Tyr31 / 118 was found to bind to two src homology ( SH ) 2 domains of p120RasGAP , with coprecipitation of endogenous paxillin with p120RasGAP . p190RhoGAP is known to be a major intracellular binding partner for the p120RasGAP SH 2 domains . ^^^ |
|
| Interacting proteins: Q9NRY4 and P12931 |
Pubmed |
SVM Score :0.0 |
| Although p 190 RhoGAP is tyrosine phosphorylated by c Src via the tyrosine kinase Pyk 2 , wild type PTP 20 had little effect on p Tyr 418 of c Src and no effect on p Tyr 402 of Pyk 2 , which are required for full c Src activity and for interacting between Pyk 2 and c Src , respectively . ^^^ |
|
| Interacting proteins: Q9NRY4 and P12931 |
Pubmed |
SVM Score :0.0 |
| The increased precipitation of p190RhoGAP with 63LRhoA was blocked by addition of PP 2 suggesting that Src family kinases are required downstream from cadherin signaling . ^^^ |
|
| Interacting proteins: Q9NRY4 and P12931 |
Pubmed |
SVM Score :0.0 |
| During cell spreading , however , the activity of RhoA is reduced by a mechanism involving the tyrosine kinases c Src and focal adhesion kinase ( FAK ) , and the p190RhoGAP . ^^^ |
|
| Interacting proteins: Q9NRY4 and P12931 |
Pubmed |
SVM Score :0.0 |
| Ang 2 induced contraction of the SMC was also attenuated by genistein , antibodies to the pp 60 ( c src ) , p ( 190 ) RhoGTPase activating protein ( p 190 RhoGAP ) , carboxyl terminus of Galpha 13 , carboxyl terminus peptide , and ADP ribosylation factor ( ARF ) antibody . ^^^ |
|
| Interacting proteins: Q9NRY4 and P12931 |
Pubmed |
SVM Score :0.0 |
| Here we show that DIP binds to p190RhoGAP and Vav 2 , and that DIP is phosphorylated by Src and mediates the phosphorylation of p190RhoGAP and Vav 2 upon EGF stimulation . ^^^ |
|
| Interacting proteins: Q9NRY4 and P12931 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of p 190 on Tyr 1105 by c Src is necessary but not sufficient for EGF induced actin disassembly in C3H10T1 / 2 fibroblasts . p 190 RhoGAP is a tyrosine phosphorylated protein that contains an N terminal GTP binding domain , a middle domain ( MD ) that mediates interaction with p 120 RasGAP and a C terminal GTPase activating protein ( GAP ) domain that is specific for the & Rgr ; family of small GTPases . ^^^ The current study was performed to establish whether p190RhoGAP directly participates in epidermal growth factor induced actin stress fiber disassembly and how c Src is involved in this process . ^^^ |
|
| Interacting proteins: Q9NRY4 and P12931 |
Pubmed |
SVM Score :0.0 |
| Cell surface transglutaminase promotes RhoA activation via integrin clustering and suppression of the Src p190RhoGAP signaling pathway . ^^^ In turn , integrin aggregation by surface tTG inhibits Src kinase activity and decreases activation of the Src substrate p190RhoGAP . ^^^ Together , these findings show that surface tTG amplifies integrin mediated signaling to RhoA / ROCK via integrin clustering and down regulation of the Src p190RhoGAP regulatory pathway . . ^^^ |
|
| Interacting proteins: Q9NRY4 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NRY4 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NRY4 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NRY4 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NRY4 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NRY4 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NRY4 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NRY4 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|