| Interacting proteins: Q9NRW4 and P45983 |
Pubmed |
SVM Score :0.0 |
| Contrary to expectation , this broadly expressed enzyme did not inactivate MAPKs in transient cotransfection assays but instead displayed the capacity to function as a selective activator of the MAPK Jnk , hence the name , Jnk Stimulatory Phosphatase 1 ( JSP 1 ) . ^^^ Activation of the Jnk signaling pathway by a dual specificity phosphatase , JSP 1 . ^^^ This study illustrates a new aspect of the regulation of MAPK dependent signal transduction and raises the possibility that JSP 1 may offer a different perspective to the study of various inflammatory and proliferative disorders associated with dysfunctional Jnk signaling . . ^^^ |
|
| Interacting proteins: Q9NRW4 and P45983 |
Pubmed |
SVM Score :0.0 |
| LMW DSP 2 dephosphorylated and deactivated p 38 , to a higher extent , and stress activated protein kinase ( SAPK ) / c Jun N terminal kinase ( JNK ) , but not extracellular signal regulated kinase 1 / 2 mitogen activated protein kinases , in transfected COS 7 cells and in vitro . ^^^ Interestingly , mutation in a conserved docking motif of p 38 and SAPK / JNK as well as in a cluster of aspartic acids of LMW DSP 2 did not affect the deactivation of the mitogen activated protein kinases by LMW DSP 2 . ^^^ Furthermore , the binding between LMW DSP 2 and p 38 and SAPK / JNK was also not disrupted by such mutations . ^^^ Among the DSPs lacking the cdc 25 homology domain , LMW DSP 2 is the first one that dephosphorylates and deactivates p 38 and SAPK / JNK . . ^^^ |
|
| Interacting proteins: Q9NRW4 and P45983 |
Pubmed |
SVM Score :0.0 |
| We report the cloning and characterization of a murine DSP , called JNK pathway associated phosphatase ( JKAP ) , which lacks the regulatory region present in most other MAP kinase phosphatases ( MKPs ) and is preferentially expressed in murine Lin ( ) Sca 1 ( + ) stem cells . ^^^ Overexpression of JKAP in human embryonic kidney 293T cells specifically activated c Jun N terminal kinase ( JNK ) but not p 38 and extracellular signal regulated kinase 2 . ^^^ Overexpression of a mutant JKAP , JKAP C88S , blocked tumor necrosis factor alpha induced JNK activation . ^^^ Targeted gene disruption in murine embryonic stem cells abolished JNK activation by tumor necrosis factor alpha and transforming growth factor beta , but not by ultraviolet C irradiation , indicating that JKAP is necessary for optimal JNK activation . ^^^ JKAP associated with JNK and MKK 7 , but not SEK 1 , in vivo . ^^^ |
|
| Interacting proteins: Q9NRW4 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|