| DISC 1 interacts by yeast two hybrid , mammalian two hybrid , and co immunoprecipitation assays with multiple proteins of the centrosome and cytoskeletal system , including MIPT 3 , MAP1A and NUDEL ; proteins which localize receptors to membranes , including alpha actinin 2 and beta 4 spectrin ; and proteins which transduce signals from membrane receptors , including ATF 4 and ATF 5 . ^^^ Truncated mutant DISC 1 fails to interact with ATF 4 , ATF 5 or NUDEL . ^^^ |