| Interacting proteins: P43034 and Q9NRI5 |
Pubmed |
SVM Score :0.61546211 |
| DISC 1 interacts with Nudel through a leucine zipper domain and binds to a novel DISC 1 interaction domain on Nudel , which is independent from the Lis 1 binding site . 0.61546211^^^ |
|
| Interacting proteins: P43034 and Q9NRI5 |
Pubmed |
SVM Score :0.0 |
| Recently , nuclear distribution element like ( NUDEL ) has been implicated to play a role in lissencephaly and schizophrenia through interactions with the lissencephaly gene 1 ( Lis 1 ) and disrupted in schizophrenia 1 ( DISC 1 ) products , respectively . ^^^ |
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| Interacting proteins: P43034 and Q9NRI5 |
Pubmed |
SVM Score :0.0 |
| In cell and animal models , C terminus truncated DISC 1 disrupts intracellular transport , neural architecture and migration , perhaps because it fails to interact with binding partners involved in neuronal differentiation such as fasciculation and elongation protein zeta 1 ( FEZ 1 ) , platelet activating factor acetylhydrolase , isoform Ib , PAFAH1B1 or lissencephaly 1 protein ( LIS 1 ) and nuclear distribution element like ( NUDEL ) . ^^^ However , the expression of NUDEL , FEZ 1 and LIS 1 was each significantly reduced in the brain tissue from patients with schizophrenia and expression of each showed association with high risk DISC 1 polymorphisms . ^^^ |
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| Interacting proteins: P43034 and Q9NRI5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43034 and Q9NRI5 |
Pubmed |
SVM Score :0.0 |
| NA |
|