| Interacting proteins: P78348 and Q9NRD5 |
Pubmed |
SVM Score :0.56152819 |
| Previous studies showed that the extreme C terminal residues of ASIC 1 bind the PDZ domain of the protein interacting with C kinase 1 ( PICK 1 ) . 0.56152819^^^ |
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| Interacting proteins: P78348 and Q9NRD5 |
Pubmed |
SVM Score :0.64761665 |
| BNaC 1 is similar to two other BNaC / ASIC family members , BNaC 2 ( ASIC 1 ) and ASIC 4 , at its extreme C terminus , and we show that PICK 1 also interacts with BNaC 2 . 0.64761665^^^ |
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| Interacting proteins: P78348 and Q9NRD5 |
Pubmed |
SVM Score :0.77686186 |
| Recently , the PDZ domain containing protein PICK 1 ( protein interacting with C kinase ) has been shown to interact with ASIC1a and ASIC2a , raising the possibility that protein kinase C ( PKC ) could regulate ASICs . 0.77686186^^^ |
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| Interacting proteins: P78348 and Q9NRD5 |
Pubmed |
SVM Score :0.0 |
| Interaction of the synaptic protein PICK 1 ( protein interacting with C kinase 1 ) with the non voltage gated sodium channels BNC 1 ( brain Na+ channel 1 ) and ASIC ( acid sensing ion channel ) . ^^^ Using the yeast two hybrid assay , we found that the PDZ domain containing protein PICK 1 ( protein interacting with C kinase ) interacts specifically with the C termini of BNC 1 and ASIC , but not DRASIC or the related alphaENaC or betaENaC . ^^^ In both the yeast two hybrid system and mammalian cells , deletion of the BNC 1 and ASIC C termini abolished the interaction with PICK 1 . ^^^ Likewise , mutating the PDZ domain in PICK 1 abolished its interaction with BNC 1 and ASIC . ^^^ Moreover , in transfected hippocampal neurons ASIC co localized with PICK 1 in a punctate pattern at synapses . ^^^ |
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