| Interacting proteins: P42261 and Q9NRD5 |
Pubmed |
SVM Score :0.0 |
| In heterologous cells , PICK 1 WT , but not PICK 1 KE , clustered GluR 2 and also clustered GluR 1 in a GluR 2 dependent manner . ^^^ |
|
| Interacting proteins: P42261 and Q9NRD5 |
Pubmed |
SVM Score :0.0 |
| To determine whether gene expression of AMPARs and / or AMPAR binding proteins , which control response / sensitivity of AMPAR bearing neurons to glutamate , are altered in schizophrenia , mRNA expression and abundance of AMPAR subunits ( GluR 1 4 ) and several AMPAR binding proteins ( SAP 97 , PICK 1 , GRIP , ABP ) were measured in the dorsolateral prefrontal cortex ( DLPFC ) and the occipital cortex of elderly schizophrenia patients ( n = 36 ) and matched normal controls ( n = 26 ) by quantitative real time PCR . ^^^ GluR 1 and ABP mRNA expression in the occipital cortex and GluR 2 , GluR 3 , SAP 97 , and PICK 1 expression in either cortical area were not significantly altered . ^^^ The data also demonstrated significant differences in the abundances of mRNAs encoding GluR 1 4 subunits ( GluR 2 > GluR 3 > GluR 1 > GluR 4 ) and of AMPAR binding proteins ( SAP 97 > PICK 1 > GRIP > ABP ) in both diagnostic groups . ^^^ |
|
| Interacting proteins: P42261 and Q9NRD5 |
Pubmed |
SVM Score :0.0 |
| Immunocytochemical and biochemical analyses in dissociated cultured hippocampal neurons show that PICK 1 causes a decrease in endogenous GluR 2 surface expression but no change in GluR 1 surface levels . ^^^ |
|
| Interacting proteins: P42261 and Q9NRD5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42261 and Q9NRD5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42261 and Q9NRD5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42261 and Q9NRD5 |
Pubmed |
SVM Score :0.0 |
| NA |
|