| Interacting proteins: Q15399 and Q9NR96 |
Pubmed |
SVM Score :0.0 |
| Sublethal infection of C57BL / 6 mice with Salmonella enterica Serovar Typhimurium leads to an increase in levels of Toll like receptor 1 ( TLR 1 ) , TLR 2 , and TLR 9 mRNA as well as a decrease in levels of TLR 6 mRNA in infected organs . ^^^ |
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| Interacting proteins: Q15399 and Q9NR96 |
Pubmed |
SVM Score :0.0 |
| TLR 1 and TLR 6 may participate in the activation of macrophages by Gram positive bacteria , whereas TLR 9 appears to respond to a specific sequence of bacterial DNA . ^^^ |
|
| Interacting proteins: Q15399 and Q9NR96 |
Pubmed |
SVM Score :0.0 |
| We investigated in two subsets of human peripheral blood DC the expression of Toll like receptors ( TLR 1 through TLR 9 ) and the regulation of chemokine receptors and cytokine production in response to different maturation stimuli . ^^^ |
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| Interacting proteins: Q15399 and Q9NR96 |
Pubmed |
SVM Score :0.0 |
| The characteristic expression pattern of TLR 1 10 in cellular subsets of human PBMC is consistent with the concept that TLR 9 is essential in the recognition of CpG ODN in PDC and B cells . ^^^ |
|
| Interacting proteins: Q15399 and Q9NR96 |
Pubmed |
SVM Score :0.0 |
| Hepatocytes expressed TLR 1 through TLR 9 as well as MyD 88 and MD 2 transcripts , as shown by reverse transcriptase PCR analysis , indicating that hepatocytes express all known microbe recognition molecules . ^^^ |
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| Interacting proteins: Q15399 and Q9NR96 |
Pubmed |
SVM Score :0.0 |
| Furthermore , macrophages from aged mice secreted significantly lower levels of IL 6 and TNF alpha when stimulated with known ligands for TLR 1 and 2 , 2 and 6 , TLR 3 , TLR 4 , TLR 5 , and TLR 9 when compared with those from young mice . ^^^ |
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| Interacting proteins: Q15399 and Q9NR96 |
Pubmed |
SVM Score :0.0 |
| Plasmacytoid pre DCs strongly express toll like receptor ( TLR ) 7 and TLR 9 , in contrast to monocytes , which mainly express TLR 1 , 2 , 4 , 5 , and 8 , suggesting that these two DC precursors recognize different microbial molecules and that they may have developed through different evolutionary trails . ^^^ |
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| Interacting proteins: Q15399 and Q9NR96 |
Pubmed |
SVM Score :0.0 |
| TLR distribution among human DC subsets is heterogeneous : plasmacytoid DC ( PDC ) express TLR 1 , 7 and 9 , while other DC types do not express TLR 9 but express other TLR . ^^^ |
|
| Interacting proteins: Q15399 and Q9NR96 |
Pubmed |
SVM Score :0.0 |
| Finally , JIP 3 also associates with TLR 2 and TLR 9 , but not with TLR 1 or TLR 6 . ^^^ |
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| Interacting proteins: Q15399 and Q9NR96 |
Pubmed |
SVM Score :0.0 |
| Eosinophils constitutively expressed TLR 1 , TLR 4 , TLR 7 , TLR 9 , and TLR 10 mRNAs ( TLR 4 greater than TLR 1 , TLR 7 , TLR 9 , and TLR 10 greater than TLR 6 ) . ^^^ In contrast , neutrophils expressed a larger variety of TLR mRNAs ( TLR 1 , TLR 2 , TLR 4 , TLR 6 , TLR 8 greater than TLR 5 , TLR 9 , and TLR 10 greater than TLR 7 ) . ^^^ |
|
| Interacting proteins: Q15399 and Q9NR96 |
Pubmed |
SVM Score :0.0 |
| Keratinocytes were found to constitutively express TLR 1 , TLR 2 , TLR 3 , TLR 5 , and TLR 9 but not TLR 4 , TLR 6 , TLR 7 , TLR 8 , or TLR 10 as shown by polymerase chain reaction analysis . ^^^ |
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| Interacting proteins: Q15399 and Q9NR96 |
Pubmed |
SVM Score :0.0 |
| The resulting predictions show the presence of one or more counterparts for the human TLR 1 , TLR 2 , TLR 3 , TLR 4 , TLR 5 , TLR 7 , TLR 8 , TLR 9 , IL 1R and IL 18R genes and one copy of the adaptor genes MyD 88 , MAL , TRIF and SARM . ^^^ |
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| Interacting proteins: Q15399 and Q9NR96 |
Pubmed |
SVM Score :0.0 |
| Ligands of the TLR include exogenous microbial components such as LPS ( TLR 4 ) , lipoproteins and peptidoglycans ( TLR 1 , 2 , 6 ) , viral RNA ( TLR 3 ) , bacterial and viral unmethylated cytosin guanosin dinucleotide ( CpG ) DNA ( TLR 9 ) , and endogenous molecules including heat shock proteins and extracellular matrix molecules . ^^^ |
|
| Interacting proteins: Q15399 and Q9NR96 |
Pubmed |
SVM Score :0.0 |
| The expression of TLR 1 to TLR 9 by ECC 1 cells was demonstrated by reverse transcription polymerase chain reaction , with only TLR 10 not being expressed . ^^^ |
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| Interacting proteins: Q15399 and Q9NR96 |
Pubmed |
SVM Score :0.0 |
| In contrast , MEFs expressed high levels of mRNA for TLR 1 , TLR 2 , TLR 3 , TLR 4 , TLR 5 , TLR 6 , TLR 7 , TLR 8 and TLR 9 . ^^^ |
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| Interacting proteins: Q15399 and Q9NR96 |
Pubmed |
SVM Score :0.0 |
| Breast milk cells also expressed mRNA for TLR 1 , TLR 2 , TLR 3 , TLR 4 , TLR 5 , TLR 6 , TLR 7 , TLR 9 , CD 14 , and LL 37 . ^^^ |
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| Interacting proteins: Q15399 and Q9NR96 |
Pubmed |
SVM Score :0.0 |
| The TLR 9 gene is abundant in major codons and it also showed higher expression than TLR 1 , TLR 2 and TLR 7 in transfected 293T cells . ^^^ |
|
| Interacting proteins: Q15399 and Q9NR96 |
Pubmed |
SVM Score :0.0 |
| TLR 2 , TLR 3 , TLR 6 , and TLR 9 were consistently expressed in Hep G 2 cells , but TLR 1 , TLR 4 , TLR 5 , TLR 7 , TLR 8 , and TLR 10 showed no or very weak expression in these cells . ^^^ |
|
| Interacting proteins: Q15399 and Q9NR96 |
Pubmed |
SVM Score :0.0 |
| However , TLR 1 ( / ) , TLR 2 ( / ) , TLR 4 ( / ) , TLR 6 ( / ) and TLR 9 ( / ) animals did not exhibit increased susceptibility to infection . ^^^ |
|
| Interacting proteins: Q15399 and Q9NR96 |
Pubmed |
SVM Score :0.0 |
| To assess the contribution of TLR in mediating this dysregulation , we examined the expression of TLR 1 , TLR 2 , TLR 4 , and TLR 9 on B cells and monocytes of filaria infected and uninfected individuals . ^^^ |
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| Interacting proteins: Q15399 and Q9NR96 |
Pubmed |
SVM Score :0.0 |
| Using 3 colour flow cytometry , expression of TLR 1 , TLR 2 , TLR 3 , TLR 4 , and TLR 9 on peripheral blood lymphocyte populations was determined . ^^^ The binding of TLR 1 and TLR 9 antibodies was detected on 15 90 % of resting B cells , but not on resting T cells . ^^^ The higher expression of TLR 1 and TLR 9 on CD5+ B cells compared to CD 5 B cells may reflect the role of B 1 cells in more primitive , less specific antibody responses . . ^^^ |
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| Interacting proteins: Q15399 and Q9NR96 |
Pubmed |
SVM Score :0.0 |
| Individual murine TLRs ( TLR 1 to TLR 9 ) and dual combinations of these TLRs that activate an NF kappaB driven luciferase reporter in response to PAO 1 were screened in HEK 293 cells . ^^^ |
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| Interacting proteins: Q15399 and Q9NR96 |
Pubmed |
SVM Score :0.0 |
| RESULTS : T cells expressed a broad repertoire of TLRs , in which TLR 1 , TLR 2 , TLR 5 , TLR 9 and TLR 10 predominated . ^^^ TLR 1 and TLR 9 mRNA was expressed to a greater extent in CD4+ cells , whereas expression of TLR 3 mRNA and protein and TLR 4 protein was higher in CD8+ cells . ^^^ |
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| Interacting proteins: Q15399 and Q9NR96 |
Pubmed |
SVM Score :0.0 |
| T cells expressed TLR 1 , TLR 2 , TLR 4 , and TLR 9 , and the baseline expression of TLR 1 , TLR 2 , and TLR 4 , but not TLR 9 was significantly lower in T cells of the filarial infected individuals compared with the uninfected individuals ( both endemic and nonendemic ) . ^^^ |
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| Interacting proteins: Q15399 and Q9NR96 |
Pubmed |
SVM Score :0.0 |
| Here , we report that murine T cells express TLR 1 , TLR 2 , TLR 6 , TLR 7 and TLR 9 mRNA . ^^^ |
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| Interacting proteins: Q15399 and Q9NR96 |
Pubmed |
SVM Score :0.0 |
| The results demonstrated a distinct repertoire of TLRs , in which TLR 1 , TLR 2 , TLR 7 , TLR 9 and TLR 10 predominated . ^^^ |
|
| Interacting proteins: Q15399 and Q9NR96 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15399 and Q9NR96 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15399 and Q9NR96 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15399 and Q9NR96 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15399 and Q9NR96 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15399 and Q9NR96 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15399 and Q9NR96 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15399 and Q9NR96 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15399 and Q9NR96 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15399 and Q9NR96 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15399 and Q9NR96 |
Pubmed |
SVM Score :0.0 |
| NA |
|