| Interacting proteins: P15151 and Q9NQS3 |
Pubmed |
SVM Score :0.85531122 |
| This down regulation of Necl 5 was initiated by its interaction with nectin 3 and was mainly mediated by clathrin dependent endocytosis . 0.85531122^^^ These results indicate that the down regulation of Necl 5 induced by its interaction with nectin 3 upon cell cell contacts may be at least one mechanism underlying contact inhibition of cell movement and proliferation . . 0.50374181^^^ |
|
| Interacting proteins: P15151 and Q9NQS3 |
Pubmed |
SVM Score :0.82888513 |
| We determined that nectin 3 binds CD 155 and its putative mouse homologue Tage 4 in cell based ligand binding assays . 0.82888513^^^ |
|
| Interacting proteins: P15151 and Q9NQS3 |
Pubmed |
SVM Score :0.71011248 |
| Tage 4 heterophilically trans interacted with nectin 3 , but not homophilically with Tage 4 . 0.71011248^^^ |
|
| Interacting proteins: P15151 and Q9NQS3 |
Pubmed |
SVM Score :0.0 |
| One of them , named necl 5 , which does not homophilically trans interact , but heterophilically trans interacts with nectin 3 , regulates cell migration and adhesion . ^^^ |
|
| Interacting proteins: P15151 and Q9NQS3 |
Pubmed |
SVM Score :0.0 |
| Involvement of heterophilic trans interaction of Necl 5 / Tage4 / PVR / CD155 with nectin 3 in formation of nectin and cadherin based adherens junctions . ^^^ Nectin like molecule 5 ( Necl 5 ) is a Ca ( 2+ ) independent Ig like molecule which does not homophilically trans interact , but heterophilically trans interacts with nectin 3 , one member of the nectin family . ^^^ Necl 5 regulates cell motility and proliferation in cooperation with integrins and growth factor receptors , when it does not interact with nectin 3 . ^^^ We studied here a role of the heterophilic trans interaction of Necl 5 with nectin 3 in cell cell adhesion using L cells stably expressing Necl 5 , nectin 3 and E cadherin ( Necl 5 nectin 3 EL cells ) . ^^^ Afadin , E cadherin and catenins were recruited to the nectin 3 side , but not to the Necl 5 side , of the contact sites formed by the heterophilic trans interaction between Necl 5 and nectin 3 . ^^^ |
|
| Interacting proteins: P15151 and Q9NQS3 |
Pubmed |
SVM Score :0.0 |
| It furthermore showed Ca2+ independent heterophilic cell cell adhesion activity with Necl 2 / IGSF4 / RA175 / SgIGSF / TSLC1 / SynCAM1 from now on referred to as Necl 2 , nectin 1 and nectin 3 , but not with Necl 5 or nectin 2 . ^^^ |
|
| Interacting proteins: P15151 and Q9NQS3 |
Pubmed |
SVM Score :0.0 |
| Necl 5 / Tage4 / PVR / CD155 is another Ca2+ independent Ig like molecule , which does not homophilically trans interact , but heterophilically trans interacts with nectin 3 , one member of the nectin family . ^^^ We show here that the trans interaction of Necl 5 and nectin 3 bidirectionally induces the activation of Cdc 42 and Rac . ^^^ Similarly to the activation of Cdc 42 and Rac by the trans interaction of nectin and nectin , the trans interaction of Necl 5 and nectin 3 first recruits and activates c Src at the Necl 5 / nectin 3 based cell cell contact sites . c Src then phosphorylates FRG and Vav 2 , and the tyrosine phosphorylated FRG and Vav 2 are recruited to the Necl 5 / nectin 3 based cell cell contact sites . ^^^ The trans interaction of Necl 5 and nectin 3 also activates Rap 1 through C3G , a Rap GEF , and this activation of Rap 1 is required for the activation of Cdc 42 and Rac . ^^^ These results indicate that the trans interactions of Necl 5 and nectin 3 and of nectin and nectin induce the activation of Cdc 42 and Rac through the common signaling molecules c Src , Rap 1 , FRG , and Vav2 . . ^^^ |
|
| Interacting proteins: P15151 and Q9NQS3 |
Pubmed |
SVM Score :0.0 |
| We have described a nectin trans hetero interaction network : nectin 3 binds to nectin 1 , nectin 2 , and PVR ; nectin 1 also binds to nectin 4 . ^^^ Finally , using chimeric nectin1 / PVR receptors where PVR 5 domain beta strands were substituted with the corresponding regions of nectin 1 , the nectin 3 and nectin 4 minimal binding region on nectin 1 5 domain was mapped to the C C ' C ' ' D beta strands . . ^^^ |
|
| Interacting proteins: P15151 and Q9NQS3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NQS3 and P15151 |
Pubmed |
SVM Score :0.71011248 |
| Tage 4 heterophilically trans interacted with nectin 3 , but not homophilically with Tage 4 . 0.71011248^^^ |
|
| Interacting proteins: Q9NQS3 and P15151 |
Pubmed |
SVM Score :0.82888513 |
| We determined that nectin 3 binds CD 155 and its putative mouse homologue Tage 4 in cell based ligand binding assays . 0.82888513^^^ |
|
| Interacting proteins: Q9NQS3 and P15151 |
Pubmed |
SVM Score :0.85531122 |
| This down regulation of Necl 5 was initiated by its interaction with nectin 3 and was mainly mediated by clathrin dependent endocytosis . 0.85531122^^^ These results indicate that the down regulation of Necl 5 induced by its interaction with nectin 3 upon cell cell contacts may be at least one mechanism underlying contact inhibition of cell movement and proliferation . . 0.50374181^^^ |
|
| Interacting proteins: Q9NQS3 and P15151 |
Pubmed |
SVM Score :0.0 |
| We have described a nectin trans hetero interaction network : nectin 3 binds to nectin 1 , nectin 2 , and PVR ; nectin 1 also binds to nectin 4 . ^^^ Finally , using chimeric nectin1 / PVR receptors where PVR 5 domain beta strands were substituted with the corresponding regions of nectin 1 , the nectin 3 and nectin 4 minimal binding region on nectin 1 5 domain was mapped to the C C ' C ' ' D beta strands . . ^^^ |
|
| Interacting proteins: Q9NQS3 and P15151 |
Pubmed |
SVM Score :0.0 |
| One of them , named necl 5 , which does not homophilically trans interact , but heterophilically trans interacts with nectin 3 , regulates cell migration and adhesion . ^^^ |
|
| Interacting proteins: Q9NQS3 and P15151 |
Pubmed |
SVM Score :0.0 |
| Involvement of heterophilic trans interaction of Necl 5 / Tage4 / PVR / CD155 with nectin 3 in formation of nectin and cadherin based adherens junctions . ^^^ Nectin like molecule 5 ( Necl 5 ) is a Ca ( 2+ ) independent Ig like molecule which does not homophilically trans interact , but heterophilically trans interacts with nectin 3 , one member of the nectin family . ^^^ Necl 5 regulates cell motility and proliferation in cooperation with integrins and growth factor receptors , when it does not interact with nectin 3 . ^^^ We studied here a role of the heterophilic trans interaction of Necl 5 with nectin 3 in cell cell adhesion using L cells stably expressing Necl 5 , nectin 3 and E cadherin ( Necl 5 nectin 3 EL cells ) . ^^^ Afadin , E cadherin and catenins were recruited to the nectin 3 side , but not to the Necl 5 side , of the contact sites formed by the heterophilic trans interaction between Necl 5 and nectin 3 . ^^^ |
|
| Interacting proteins: Q9NQS3 and P15151 |
Pubmed |
SVM Score :0.0 |
| It furthermore showed Ca2+ independent heterophilic cell cell adhesion activity with Necl 2 / IGSF4 / RA175 / SgIGSF / TSLC1 / SynCAM1 from now on referred to as Necl 2 , nectin 1 and nectin 3 , but not with Necl 5 or nectin 2 . ^^^ |
|
| Interacting proteins: Q9NQS3 and P15151 |
Pubmed |
SVM Score :0.0 |
| Necl 5 / Tage4 / PVR / CD155 is another Ca2+ independent Ig like molecule , which does not homophilically trans interact , but heterophilically trans interacts with nectin 3 , one member of the nectin family . ^^^ We show here that the trans interaction of Necl 5 and nectin 3 bidirectionally induces the activation of Cdc 42 and Rac . ^^^ Similarly to the activation of Cdc 42 and Rac by the trans interaction of nectin and nectin , the trans interaction of Necl 5 and nectin 3 first recruits and activates c Src at the Necl 5 / nectin 3 based cell cell contact sites . c Src then phosphorylates FRG and Vav 2 , and the tyrosine phosphorylated FRG and Vav 2 are recruited to the Necl 5 / nectin 3 based cell cell contact sites . ^^^ The trans interaction of Necl 5 and nectin 3 also activates Rap 1 through C3G , a Rap GEF , and this activation of Rap 1 is required for the activation of Cdc 42 and Rac . ^^^ These results indicate that the trans interactions of Necl 5 and nectin 3 and of nectin and nectin induce the activation of Cdc 42 and Rac through the common signaling molecules c Src , Rap 1 , FRG , and Vav2 . . ^^^ |
|
| Interacting proteins: Q9NQS3 and P15151 |
Pubmed |
SVM Score :0.0 |
| NA |
|