| Interacting proteins: Q9NPH3 and P51617 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NPH3 and P51617 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NPH3 and P51617 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NPH3 and P51617 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NPH3 and P51617 |
Pubmed |
SVM Score :0.0 |
| The interleukin 1 receptor accessory protein ( IL 1RAcP ) is essential for IL 1 induced activation of interleukin 1 receptor associated kinase ( IRAK ) and stress activated protein kinases ( SAP kinases ) . ^^^ |
|
| Interacting proteins: Q9NPH3 and P51617 |
Pubmed |
SVM Score :0.0 |
| IRAK is recruited to this complex through its association with IL 1RAcP . ^^^ Overexpression of an IL 1RAcP mutant lacking its intracellular domain , the IRAK binding domain , prevented the recruitment of IRAK to the receptor complex and blocked IL 1 induced NF kappaB activation . . ^^^ |
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| Interacting proteins: Q9NPH3 and P51617 |
Pubmed |
SVM Score :0.0 |
| The intracellular signaling cascade involves recruitment of two IL 1R associated kinases , IRAK 1 and IRAK 2 , and the adapter protein MyD 88 , events which are dependent on the intracellular domain of membrane bound IL 1RAcP ( mIL 1RAcP ) . ^^^ |
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| Interacting proteins: Q9NPH3 and P51617 |
Pubmed |
SVM Score :0.0 |
| Binding of IL 1 to its receptor results in rapid assembly of a membrane proximal signalling complex that consists of two different receptor chains ( IL 1Rs ) , IL 1RI and IL 1RAcP , the adaptor protein MyD 88 , the serine / threonine kinase IRAK and a new protein , which we have named Tollip . ^^^ Here we show that , before IL 1beta treatment , Tollip is present in a complex with IRAK , and that recruitment of Tollip IRAK complexes to the activated receptor complex occurs through association of Tollip with IL 1RAcP . ^^^ |
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| Interacting proteins: Q9NPH3 and P51617 |
Pubmed |
SVM Score :0.0 |
| Like the kinase inactivating mutation , K239S , the T66A and T66E mutations interfered with the ability of IRAK to autophosphorylate and facilitated the interactions of IRAK with TRAF 6 and with the IL 1 receptor accessory protein , AcP . ^^^ |
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