| Interacting proteins: P27930 and Q9NPH3 |
Pubmed |
SVM Score :0.84222627 |
| The physical association of ligated IL 1RII with IL 1RAcP was proven by crosslinking experiments with radio iodinated IL 1 and subsequent immunoprecipitations in normal human B cells and in EL 4 D6 / 76 cells transiently cotransfected with IL 1RII and IL 1RAcP , respectively . 0.84222627^^^ |
|
| Interacting proteins: P27930 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| IL 1beta increased IL 1beta , IL 1 receptor types 1 and 2 ( IL 1RI and IL 1RII ) , IL 1 receptor accessory protein soluble form ( IL 1R AcP 2 ) , IL 1 receptor antagonist ( IL 1Ra ) , TNF alpha , and TGF beta 1 mRNAs in the hypothalamus from obese and lean rats . ^^^ The data suggest 1 ) the operation of an IL 1beta feedback system ( IL 1beta / IL 1RI / IL 1R Acp II / IL 1RII / IL 1Ra ) and 2 ) potential cytokine cytokine interactions with positive ( IL 1beta < > TNF alpha ) and negative ( TGF beta 1 > IL 1beta / TNF alpha ) feedback . ^^^ |
|
| Interacting proteins: P27930 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| We suggest that in addition to its earlier described decoy receptor role , IL 1RII may modulate the responsiveness of cells to IL 1 by binding the IL 1RAcP in unproductive / non signalling complexes and thus reducing the number of signalling IL 1RI IL 1RAcP agonist complexes when IL 1 is bound . . ^^^ |
|
| Interacting proteins: P27930 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| Three molecules , interleukin 1 ( IL 1 ) receptor 1 ( IL 1RI ) , IL 1 receptor 2 ( IL 1RII or decoy ) and IL 1 receptor accessory protein ( IL 1R AcP or IL 1RIII ) , are involved in IL 1 binding and signal transduction . ^^^ Resting human monocytes expressed high levels of IL 1RII , IL 1R AcP , MyD 88 and rsc 786 , whereas low levels of IL 1RI and T1 / ST2 were present . ^^^ |
|
| Interacting proteins: P27930 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| Specifically , the IL 1 type 1 receptor ( IL 1RI ) , IL 1 type 2 receptor ( IL 1RII ) , IL 1 receptor accessory protein ( IL 1RAcP ) , and IL 1 receptor antagonist ( IL 1Ra ) were analyzed . ^^^ |
|
| Interacting proteins: P27930 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| Gene array analysis of human normal and OA affected cartilage showed mRNA expression of IL 1 receptor accessory protein ( IL 1RAcp ) and IL 1 type 1 receptor ( IL 1RI ) , but not IL 1 antagonist ( IL 1ra ) and IL 1 type 2 decoy receptor ( IL 1RII ) . ^^^ |
|
| Interacting proteins: P27930 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| Using RT PCR , we first showed that the expression of IL 1RI and IL 1RII , but not IL 1RacP , mRNAs are up regulated by IL 1 beta in a time dependent manner . ^^^ |
|
| Interacting proteins: P27930 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| Regulation of interleukin 1 activity is enhanced by cooperation between the interleukin 1 receptor type 2 and interleukin 1 receptor accessory protein . ^^^ |
|
| Interacting proteins: P27930 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| However , no data exist demonstrating expression of IL 1 receptors [ IL 1 type 1 receptor ( IL 1RI ) , IL 1 type 2 receptor ( IL 1RII ) and IL 1 receptor accessory protein ( IL 1RAcP ) ] on microglia . ^^^ Bacterial lipopolysaccharide ( LPS ) caused increased expression of IL 1RI , IL 1RII and IL 1RAcP mRNAs , induced the release of IL 1beta , IL 6 and prostaglandin E 2 ( PGE 2 ) , and activated nuclear factor kappaB ( NF kappaB ) and the mitogen activated protein kinases ( MAPKs ) p 38 , and extracellular signal regulated protein kinase ( ERK1 / 2 ) , but not c Jun N terminal kinase ( JNK ) in microglial cultures . ^^^ |
|
| Interacting proteins: P27930 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| The IL 1 gene family includes genes which play important roles in both these processes and consists of IL 1 ? , IL 1ss , IL 18 , the IL 1 receptor antagonist ( IL 1RA ) , two IL 1 receptors ( IL 1RI , IL 1RII ) , the IL 18 receptor ( IL 18R ? ) , and the receptor associated proteins IL 1RAcP and IL 18Rss . ^^^ |
|
| Interacting proteins: P27930 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| A study in a panel of NF kappaB luciferase reporter cells showed that the sIL 1RAcP inhibits IL 1 signaling on cells expressing either low levels of membrane IL 1RAcP or high levels of IL 1RII . ^^^ |
|
| Interacting proteins: P27930 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27930 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27930 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|