| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| IL 1R AcP 1 and 2 mRNA levels were also up regulated in the cortical regions . ^^^ |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| We also show that the bioactivity of both IL 1ra K145D and the triple mutant IL 1ra K145D / H54P / QGEESN is dependent on interaction with the newly cloned IL 1 receptor accessory protein . . ^^^ |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| In mammalian cells expressing natural or recombinant Type 1 IL 1R and IL 1R AcP , the accessory protein forms a complex with the Type 1 IL 1R and either IL 1 alpha or IL 1 beta but not IL 1ra . ^^^ |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| Here , we investigated the regulation of the IL 1 beta system [ IL 1 beta , IL 1 receptor type 1 ( IL 1RI ) , IL 1 receptor antagonist ( IL 1Ra ) , IL 1 receptor accessory proteins ( IL 1R AcP 1 and 2 ) ] , TNF alpha , TGF alpha , and TGF beta 1 mRNAs in the hypothalamus of Wistar rats in response to the chronic intracerebroventricular ( ICV ) microinfusion ( via osmotic minipumps ) of HIV 1 gp 120 ( 100 , 500 , and 1000 ng / 24 h for 72 h ) . ^^^ |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| IL 1beta increased IL 1beta , IL 1 receptor types 1 and 2 ( IL 1RI and IL 1RII ) , IL 1 receptor accessory protein soluble form ( IL 1R AcP 2 ) , IL 1 receptor antagonist ( IL 1Ra ) , TNF alpha , and TGF beta 1 mRNAs in the hypothalamus from obese and lean rats . ^^^ The data suggest 1 ) the operation of an IL 1beta feedback system ( IL 1beta / IL 1RI / IL 1R Acp II / IL 1RII / IL 1Ra ) and 2 ) potential cytokine cytokine interactions with positive ( IL 1beta < > TNF alpha ) and negative ( TGF beta 1 > IL 1beta / TNF alpha ) feedback . ^^^ |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| IL 1R AcP deficient fibroblasts bound murine IL 1alpha and human IL 1R antagonist protein ( IL 1Ra ) with only moderately reduced affinity when compared with wild type cells , whereas murine IL 1beta affinity was reduced by 70 fold . ^^^ |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| Specifically , the IL 1 type 1 receptor ( IL 1RI ) , IL 1 type 2 receptor ( IL 1RII ) , IL 1 receptor accessory protein ( IL 1RAcP ) , and IL 1 receptor antagonist ( IL 1Ra ) were analyzed . ^^^ Constitutive expression of IL 1RI , IL 1RAcP , and IL 1Ra was detected in both immortalized and primary human airway epithelial cells . ^^^ |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| We used specific and highly sensitive RNase protection assays to determine mRNA changes for IL 1beta , IL 1 receptor type 1 ( IL 1RI ) , IL 1R accessory proteins 1 and 2 ( IL 1R AcP 1 and 2 ) , IL 1 receptor antagonist ( IL 1Ra ) , transforming growth factor beta 1 ( TGF beta 1 ) , glycoprotein 130 ( gp 130 ) , leptin receptor ( OB R ) , neuropeptide Y ( NPY ) and pro opiomelanocortin ( POMC ) in the cerebellum , parieto frontal cortex , hippocampus , hypothalamus , and midbrain of male young ( 3 5 months ) and old ( 24 26 months ) Long Evans rats . ^^^ |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| Here , we report on the levels of interleukin 1beta ( IL 1beta ) , IL 1 receptor antagonist ( IL 1Ra ) , tumor necrosis factor alpha ( TNF alpha ) , transforming growth factor beta 1 ( TGF beta 1 ) , IL 1 receptor type 1 ( IL 1RI ) , IL 1 receptor accessory protein ( IL 1R AcP ) 1 and 2 , glycoprotein 130 , and various neuropeptide mRNAs in the cerebellum , parieto frontal cortex , hippocampus and hypothalamus of BDV infected rats at 7 and 28 days postintracerebral BDV inoculation . ^^^ The same cerebellar samples from BDV infected animals exhibited the highest levels of IL 1beta , IL 1Ra , TNF alpha , IL 1RI , and IL 1R AcP 2 mRNA expression . ^^^ |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| The data show that food deprivation increases the basal mRNA expression of IL 1beta , IL 1RA , TNF alpha , IL 1RI , and IL 1R AcP 1 , whereas mRNA levels of POMC showed a decrease . ^^^ |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| Expression of IL 1alpha and beta , IL 1 receptor antagonist ( IL 1Ra ) , IL 1RI and 2 , IL 1R accessory protein ( IL 1RAcP ) and IL 1beta converting enzyme ( ICE ) was studied by immunocytochemistry , immunoblotting , ELISA and RT PCR . ^^^ |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| Gene array analysis of human normal and OA affected cartilage showed mRNA expression of IL 1 receptor accessory protein ( IL 1RAcp ) and IL 1 type 1 receptor ( IL 1RI ) , but not IL 1 antagonist ( IL 1ra ) and IL 1 type 2 decoy receptor ( IL 1RII ) . ^^^ |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| IL 1beta actions depend on interaction with a single receptor ( IL 1RI ) , which associates with an accessory protein ( IL 1RAcP ) , and is blocked by IL 1 receptor antagonist ( IL 1ra ) . ^^^ |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| Here we report that the soluble form of the IL 1 receptor accessory protein ( AcP ) increases the affinity of binding of human IL 1alpha and IL 1beta to the soluble human type 2 IL 1 receptor by approximately 100 fold , while leaving unaltered the low binding affinity of IL 1ra . ^^^ |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| Blockade of IL 1 by IL 1 receptor antagonist ( IL 1Ra , sIL 1RII ) in combination with the soluble IL 1 accessory protein ( IL 1R AcP ) result in a long term beneficial effect in chronic inflammatory diseases . ^^^ |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| Naturally occurring IL 1 modulators include IL 1 receptor antagonist ( IL 1Ra ) , IL 1 soluble receptor Type 1 ( IL 1sRI ) , IL 1sRII and IL 1 receptor accessory protein ( AcP ) . ^^^ |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| The IL 1 gene family includes genes which play important roles in both these processes and consists of IL 1 ? , IL 1ss , IL 18 , the IL 1 receptor antagonist ( IL 1RA ) , two IL 1 receptors ( IL 1RI , IL 1RII ) , the IL 18 receptor ( IL 18R ? ) , and the receptor associated proteins IL 1RAcP and IL 18Rss . ^^^ |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To discern the mode of interleukin 1 ( IL 1 ) inhibition of soluble IL 1 receptor accessory protein ( sIL 1RAcP ) by comparison with IL 1 receptor antagonist ( IL 1Ra ) in arthritis . ^^^ |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| The current investigation determined conceptus and endometrial changes in gene expression for IL 1beta , IL 1 receptor antagonist ( IL 1Rant ) , IL 1 receptor type 1 ( IL 1RT1 ) , and IL 1 receptor accessory protein ( IL 1RAP ) in developing peri and postimplantation conceptuses as well as uterine endometrium collected from cyclic and pregnant gilts . ^^^ |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1 receptor type 1 ( IL 1RI ) mRNA also increased in all three brain regions examined , and the soluble form of IL 1 receptor accessory protein ( IL 1R AcP 2 ) mRNA was induced in the hypothalamus . ^^^ |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| IL 1Rrp is a novel receptor like molecule similar to the type 1 interleukin 1 receptor and its homologues T1 / ST2 and IL 1R AcP . ^^^ |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| Three cell surface molecules participate in Interleukin 1 ( IL 1 ) binding and signal generation , the two distinct types of receptors ( type 1 IL 1R and type 2 IL 1R ) and the IL 1 receptor accessory protein ( IL 1RAcP ) . ^^^ |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| It was therefore of interest to investigate the expression of mRNA IL 1 receptor accessory protein ( IL 1R AcP ) , which is a part of the IL 1 receptor complex and has been shown to interact specifically with IL 1R1 . ^^^ IL 1R AcP transcripts were detected under basal conditions following RT PCR amplification in the mouse brain , as well as in the pituitary , spleen , adrenal and liver . ^^^ IL 1R AcP transcripts were found in higher amounts than IL 1R1 transcripts in all tissues except the spleen , where their expression was minor . ^^^ Following bacterial lipopolysaccharide ( LPS ) stimulation ( 3 48 h ) , IL 1R AcP transcripts were not changed in the brain , while IL 1R1 transcripts were increased for 3 6 h . ^^^ In the spleen , a slight increase in IL 1R AcP and IL 1R1 was observed during the first hours following LPS stimulation . ^^^ |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| IL 1 receptor type 1 ( IL 1RI ) mRNA and the soluble form of IL 1 receptor accessory protein ( IL 1R AcP 2 ) mRNA were also induced in the hypothalamus and cerebellum . ^^^ |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| To investigate the activation of SMases by IL 1 , we used an IL 1 receptor type 1 ( IL 1RI ) positive EL 4 thymoma cell line , which is defective in IL 1R accessory protein ( IL 1RAcP ) expression . ^^^ |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| The IL 1R accessory protein ( IL 1RAcP ) plays a role in IL 1R signaling by forming a complex with IL 1RI bound to the IL 1 ligand . ^^^ |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| We propose that although IL 1R rp 1 binds the cytokine , IL 1R rp 1 and AcPL proteins are both required for IL 18 signaling , analogous to the requirement for both IL 1R and IL 1RAcP in IL 1 mediated responses . . ^^^ |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| Three molecules , interleukin 1 ( IL 1 ) receptor 1 ( IL 1RI ) , IL 1 receptor 2 ( IL 1RII or decoy ) and IL 1 receptor accessory protein ( IL 1R AcP or IL 1RIII ) , are involved in IL 1 binding and signal transduction . ^^^ Resting human monocytes expressed high levels of IL 1RII , IL 1R AcP , MyD 88 and rsc 786 , whereas low levels of IL 1RI and T1 / ST2 were present . ^^^ Expression of IL 1R AcP in monocytes was less substantially affected by LPS . ^^^ |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| Signal transduction is initiated at the cell membrane by complex formation between extracellular IL 1 and the transmembrane IL 1R type 1 ( IL 1RI ) and IL 1R accessory protein ( IL 1RAcP ) . ^^^ The intracellular signaling cascade involves recruitment of two IL 1R associated kinases , IRAK 1 and IRAK 2 , and the adapter protein MyD 88 , events which are dependent on the intracellular domain of membrane bound IL 1RAcP ( mIL 1RAcP ) . ^^^ |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| Like other members of the IL 1R family , the salmon IL 1RAcP encodes three extracellular immunoglobulin like domains and a cytoplasmic Toll / Interleukin 1 receptor ( TIR ) domain involved in signalling . ^^^ |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14778 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|