| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :1.0714076 |
| Two major agonists , IL 1alpha and IL 1beta , bind to a single known functional type 1 IL 1 receptor ( IL 1RI ) that associates with the accessory protein ( IL 1RAcP ) , resulting in signal transduction . 1.0714076^^^ |
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| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| In mammalian cells expressing natural or recombinant Type 1 IL 1R and IL 1R AcP , the accessory protein forms a complex with the Type 1 IL 1R and either IL 1 alpha or IL 1 beta but not IL 1ra . ^^^ |
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| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| Here , we investigated the regulation of the IL 1 beta system [ IL 1 beta , IL 1 receptor type 1 ( IL 1RI ) , IL 1 receptor antagonist ( IL 1Ra ) , IL 1 receptor accessory proteins ( IL 1R AcP 1 and 2 ) ] , TNF alpha , TGF alpha , and TGF beta 1 mRNAs in the hypothalamus of Wistar rats in response to the chronic intracerebroventricular ( ICV ) microinfusion ( via osmotic minipumps ) of HIV 1 gp 120 ( 100 , 500 , and 1000 ng / 24 h for 72 h ) . ^^^ |
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| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| At least two discrete areas of IL 1 beta , located within the sequences 133 147 and 177 186 ( as defined by mAbs MhC 1 and BRhD 2 , respectively ) , are apparently involved in IL 1RI independent agonist activity , and thus possibly take part in the interaction with the receptor accessory protein IL 1RAcP . ^^^ The loop between the 4th and the 5th beta strand , at the open end of the IL 1 beta barrel structure , may possibly take part in both non agonist binding to IL 1RI and in the interaction with IL 1RAcP . . ^^^ |
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| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| IL 1beta increased IL 1beta , IL 1 receptor types 1 and 2 ( IL 1RI and IL 1RII ) , IL 1 receptor accessory protein soluble form ( IL 1R AcP 2 ) , IL 1 receptor antagonist ( IL 1Ra ) , TNF alpha , and TGF beta 1 mRNAs in the hypothalamus from obese and lean rats . ^^^ The data suggest 1 ) the operation of an IL 1beta feedback system ( IL 1beta / IL 1RI / IL 1R Acp II / IL 1RII / IL 1Ra ) and 2 ) potential cytokine cytokine interactions with positive ( IL 1beta < > TNF alpha ) and negative ( TGF beta 1 > IL 1beta / TNF alpha ) feedback . ^^^ |
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| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| This study determined the effects of intraperitoneal injections of interleukin 1beta ( IL 1beta ) on IL 1beta mRNA and IL 1 receptor accessory protein ( IL 1RAP ) mRNA production in rat liver and brain using the reverse transcription PCR . ^^^ |
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| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| Anti IL 1RAcP peptide 4 , which targets the terminal segment of domain 3 , inhibited 80 % of IL 1 beta driven proliferation of D10S cells . ^^^ Whereas IL 1 beta down regulated IL 1RI surface expression ( p < 0 . 05 ) , there was no change in the surface expression of IL 1RAcP . ^^^ Antibodies to domains 2 and 3 of the IL 1 receptor accessory protein inhibit IL 1 beta activity but not binding : regulation of IL 1 responses is via type 1 receptor , not the accessory protein . ^^^ |
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| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| With the aim of investigating the importance of the IL 1RAcP in IL 1 signalling , IL 1alpha and IL 1beta induced febrile responses and IL 1beta mediated activation of NFkappaB in primary astrocyte cultures were examined using IL 1RAcP deficient ( IL 1RAcP KO ) and wild type mice , respectively . ^^^ It was shown that neither recombinant rat IL 1alpha ( rrIL 1alpha , 25 microg / kg ) , recombinant rat IL 1beta ( rrIL 1beta , 40 microg / kg ) nor recombinant human IL 1beta ( rhIL 1beta , 50 microg / kg ) injected i . p . could elicit febrile responses in the IL 1RAcP deficient mice , while the same doses of rrIL 1alpha / beta or rhIL 1beta injected into wild type mice caused normal fever responses . ^^^ Furthermore , it was shown that rhIL 1beta activated , in a concentration dependent manner , nuclear translocation of the transcriptional nuclear factor kappa B ( NFkappaB ) in primary astrocyte cultures prepared from wild type mice , whereas no IL 1beta induced translocation of NFkappaB could be detected in cultures prepared from IL 1RAcP deficient mice , as revealed by electrophoretic mobility shift assay ( EMSA ) . ^^^ |
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| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| The recently described IL 1R accessory protein ( IL 1R AcP ) interacts with IL 1beta and the IL 1 type IR ( IL 1RI ) , but an essential requirement for IL 1R AcP in IL 1 signaling in vitro has not been established and its role in vivo has not been examined . ^^^ IL 1R AcP deficient fibroblasts bound murine IL 1alpha and human IL 1R antagonist protein ( IL 1Ra ) with only moderately reduced affinity when compared with wild type cells , whereas murine IL 1beta affinity was reduced by 70 fold . ^^^ These data demonstrate that a type 1 IL 1R / IL 1R AcP complex is required for signaling by all IL 1 agonists and for high affinity binding by IL 1beta . ^^^ |
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| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| Using mice strains carrying the null mutations of IL 1 beta , IL 1RI , IL 1RAcP , or IL 6 , respectively , we show that LPS induced fever involves IL 1 beta , which acts at a complex consisting of the type 1 IL 1 receptor and the IL 1RAcP . ^^^ |
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| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| The RT PCR analysis of RNA from progenitor and differentiated primary rat oligodendrocytes , and from the oligodendrocyte CG 4 cell line , shows the presence of the IL 1beta mRNA , the type 1 IL 1beta receptor and the IL 1 receptor accessory protein in these cells . ^^^ |
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| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| We used specific and highly sensitive RNase protection assays to determine mRNA changes for IL 1beta , IL 1 receptor type 1 ( IL 1RI ) , IL 1R accessory proteins 1 and 2 ( IL 1R AcP 1 and 2 ) , IL 1 receptor antagonist ( IL 1Ra ) , transforming growth factor beta 1 ( TGF beta 1 ) , glycoprotein 130 ( gp 130 ) , leptin receptor ( OB R ) , neuropeptide Y ( NPY ) and pro opiomelanocortin ( POMC ) in the cerebellum , parieto frontal cortex , hippocampus , hypothalamus , and midbrain of male young ( 3 5 months ) and old ( 24 26 months ) Long Evans rats . ^^^ |
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| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| Here , we report on the levels of interleukin 1beta ( IL 1beta ) , IL 1 receptor antagonist ( IL 1Ra ) , tumor necrosis factor alpha ( TNF alpha ) , transforming growth factor beta 1 ( TGF beta 1 ) , IL 1 receptor type 1 ( IL 1RI ) , IL 1 receptor accessory protein ( IL 1R AcP ) 1 and 2 , glycoprotein 130 , and various neuropeptide mRNAs in the cerebellum , parieto frontal cortex , hippocampus and hypothalamus of BDV infected rats at 7 and 28 days postintracerebral BDV inoculation . ^^^ The same cerebellar samples from BDV infected animals exhibited the highest levels of IL 1beta , IL 1Ra , TNF alpha , IL 1RI , and IL 1R AcP 2 mRNA expression . ^^^ |
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| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| The data show that food deprivation increases the basal mRNA expression of IL 1beta , IL 1RA , TNF alpha , IL 1RI , and IL 1R AcP 1 , whereas mRNA levels of POMC showed a decrease . ^^^ |
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| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| Expression of IL 1alpha and beta , IL 1 receptor antagonist ( IL 1Ra ) , IL 1RI and 2 , IL 1R accessory protein ( IL 1RAcP ) and IL 1beta converting enzyme ( ICE ) was studied by immunocytochemistry , immunoblotting , ELISA and RT PCR . ^^^ |
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| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| Here we show that , before IL 1beta treatment , Tollip is present in a complex with IRAK , and that recruitment of Tollip IRAK complexes to the activated receptor complex occurs through association of Tollip with IL 1RAcP . ^^^ |
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| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| Thus this study examined the effects of a cafeteria diet on IL 1beta mRNA and IL 1 receptor accessory protein ( IL 1RAP ) mRNA expression in rat liver and brain . ^^^ |
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| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1 receptor accessory protein ( IL 1RAcP ) is necessary for centrally mediated neuroendocrine and immune responses to IL 1beta . ^^^ Mice deficient for the IL 1RAcP gene ( IL 1RAcP KO ) were used to explore the role of IL 1RAcP in physiological functions of brain IL 1beta . ^^^ The results clearly demonstrate that IL 1RAcP is necessary for the induction of the main neuroendocrine and immune effects of central IL 1beta . . ^^^ Interleukin 1 receptor accessory protein ( IL 1RAcP ) is necessary for centrally mediated neuroendocrine and immune responses to IL 1beta . ^^^ |
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| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| The biological effects of IL 1 beta are mediated by IL 1 RI associated with the IL 1 receptor accessory protein ( IL 1RAcP ) . ^^^ IL 1 beta were studied in IL 1RAcP deficient mice . ^^^ None of these effects were observed in IL 1RAcP deficient mice , indicating that IL 1RAcP is necessary for the induction of the main neuroendocrine and immune effects of central IL 1 beta . ^^^ |
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| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| Results obtained by studying mice deficient for IL 1alpha , IL 1beta , IL 1 receptor antagonist , IL 1 receptor type 1 , IL 1 receptor accessory protein , IL 1 receptor associated kinase , and the IL 1beta converting enzyme caspase 1 are summarized . ^^^ |
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| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| Using RT PCR , we first showed that the expression of IL 1RI and IL 1RII , but not IL 1RacP , mRNAs are up regulated by IL 1 beta in a time dependent manner . ^^^ |
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| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| IL 1beta actions depend on interaction with a single receptor ( IL 1RI ) , which associates with an accessory protein ( IL 1RAcP ) , and is blocked by IL 1 receptor antagonist ( IL 1ra ) . ^^^ |
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| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| There are no differences in IL 1beta binding , as determined by flow cytometry , or in the presence of the type 1 IL 1 receptor ( IL 1RtI ) or its associated protein ( IL 1RacP ) by immunoblotting . ^^^ |
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| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| Bacterial lipopolysaccharide ( LPS ) caused increased expression of IL 1RI , IL 1RII and IL 1RAcP mRNAs , induced the release of IL 1beta , IL 6 and prostaglandin E 2 ( PGE 2 ) , and activated nuclear factor kappaB ( NF kappaB ) and the mitogen activated protein kinases ( MAPKs ) p 38 , and extracellular signal regulated protein kinase ( ERK1 / 2 ) , but not c Jun N terminal kinase ( JNK ) in microglial cultures . ^^^ |
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| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| Moreover , IL 1beta stimulation induced association of SHPS 1 with IL 1RAcP , a second subunit of IL 1 receptor , whereas expression of SHPS 1 mutant that lack SHP 2 binding function clearly blocked the association and tyrosine phosphorylation of endogenous SHPS 1 . ^^^ |
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| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| Here we report that the soluble form of the IL 1 receptor accessory protein ( AcP ) increases the affinity of binding of human IL 1alpha and IL 1beta to the soluble human type 2 IL 1 receptor by approximately 100 fold , while leaving unaltered the low binding affinity of IL 1ra . ^^^ |
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| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| The current investigation determined conceptus and endometrial changes in gene expression for IL 1beta , IL 1 receptor antagonist ( IL 1Rant ) , IL 1 receptor type 1 ( IL 1RT1 ) , and IL 1 receptor accessory protein ( IL 1RAP ) in developing peri and postimplantation conceptuses as well as uterine endometrium collected from cyclic and pregnant gilts . ^^^ |
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| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| Two major agonists , IL 1alpha and IL 1beta , bind to a membrane receptor complex composed of the type 1 IL 1 receptor ( IL 1RI ) and the accessory protein ( IL 1RAcP ) . ^^^ |
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| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| In hypothalamic neurons , binding of IL 1beta to IL 1RI mediates transcription dependent changes that depend on the recruitment of the cytosolic adaptor protein myeloid differentiation primary response protein 88 ( MyD 88 ) to the IL 1RI / IL 1 receptor accessory protein ( IL 1RAcP ) complex through homomeric Toll / IL 1 receptor ( TIR ) TIR interactions . ^^^ Through design and synthesis of bifunctional TIR mimetics that disrupt the interaction of MyD 88 with the IL 1RI / IL 1RAcP complex , we analyzed the involvement of MyD 88 in the signaling of IL 1beta in anterior hypothalamic neurons . ^^^ We show here that IL 1beta mediated activation of the protein tyrosine kinase Src depended on a MyD 88 interaction with the IL 1RI / IL 1RAcP complex . ^^^ |
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| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1 receptor type 1 ( IL 1RI ) mRNA also increased in all three brain regions examined , and the soluble form of IL 1 receptor accessory protein ( IL 1R AcP 2 ) mRNA was induced in the hypothalamus . ^^^ Levels of membrane bound IL 1R AcP , TGF beta 1 , and NPY mRNAs did not change significantly in any brain region . ^^^ |
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| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01584 and Q9NPH3 |
Pubmed |
SVM Score :0.0 |
| NA |
|