| Yeast two hybrid screening yielded a CLP interacting clone encoding the three light chain binding IQ motifs of human `` unconventional ' ' myosin 10 . ^^^ Epitope tagged myosin 10 was localized preferentially at the cell periphery in MCF 7 cells , and CLP colocalized with myosin 10 in these cells . ^^^ Myosin 10 was able to coprecipitate CLP and , to a lesser extent , calmodulin from transfected COS 1 cells , indicating that CLP is a specific light chain of myosin 10 in vivo . ^^^ Because unconventional myosins participate in cellular processes ranging from membrane trafficking to signaling and cell motility , myosin 10 is an attractive CLP target . ^^^ Altered myosin 10 regulation in ( tumor ) cells lacking CLP may have as yet unknown consequences for cell growth and differentiation . . ^^^ |