| Interacting proteins: Q8WXF3 and Q9HBX9 |
Pubmed |
SVM Score :0.0 |
| Chem . 278 , 50754 50764 ) , we present the case that relaxin 3 , which has previously been shown to bind to the relaxin receptor LGR 7 , is most likely the endogenous ligand for GPCR 135 . ^^^ |
|
| Interacting proteins: Q8WXF3 and Q9HBX9 |
Pubmed |
SVM Score :0.0 |
| Relaxin 3 has previously been shown to bind and activate the LGR 7 relaxin receptor . ^^^ |
|
| Interacting proteins: Q8WXF3 and Q9HBX9 |
Pubmed |
SVM Score :0.0 |
| Relaxin 3 / insulin like peptide 5 chimeric peptide , a selective ligand for G protein coupled receptor ( GPCR ) 135 and GPCR 142 over leucine rich repeat containing G protein coupled receptor 7 . ^^^ In contrast , substitution of the relaxin 3 A chain with the A chain from INSL 5 results in a chimeric peptide that selectively activates GPCR 135 and GPCR 142 over LGR 7 . ^^^ |
|
| Interacting proteins: Q8WXF3 and Q9HBX9 |
Pubmed |
SVM Score :0.0 |
| However , unlike relaxin 3 , which is also a potent agonist for GPCR 135 and LGR 7 , INSL 5 does not activate either GPCR 135 or LGR 7 . ^^^ |
|
| Interacting proteins: Q8WXF3 and Q9HBX9 |
Pubmed |
SVM Score :0.0 |
| Relaxin 3 binds with high affinity to the LGR 7 receptor and to the previously orphan G protein coupled receptor GPCR 135 . ^^^ |
|
| Interacting proteins: Q8WXF3 and Q9HBX9 |
Pubmed |
SVM Score :0.0 |
| In addition , INSL 3 and relaxin 3 were found to be specific ligands for LGR 8 and LGR 7 , respectively . ^^^ |
|
| Interacting proteins: Q8WXF3 and Q9HBX9 |
Pubmed |
SVM Score :0.0 |
| Recent studies have demonstrated that relaxin 3 will bind to and activate human LGR 7 , but not LGR 8 , in vitro . ^^^ |
|
| Interacting proteins: Q8WXF3 and Q9HBX9 |
Pubmed |
SVM Score :0.0 |
| The cognate ligands for the receptors have been identified : relaxin for RXFP 1 ; INSL 3 for RXFP 2 ; relaxin 3 for RXFP 3 and INSL 5 for RXFP 4 . ^^^ |
|
| Interacting proteins: Q8WXF3 and Q9HBX9 |
Pubmed |
SVM Score :0.0 |
| In conclusion , both LGR 7 and LGR 8 are expressed in activated HSCs and cirrhotic liver , suggesting that relaxin , InsL 3 , or relaxin 3 may be useful in the treatment of hepatic fibrosis . . ^^^ |
|
| Interacting proteins: Q8WXF3 and Q9HBX9 |
Pubmed |
SVM Score :0.0 |
| Discrete neuronal populations in brain express relaxin and relaxin 3 , and molecular studies have identified former orphan , G protein coupled receptors LGR 7 and GPCR 135 as their native receptors . ^^^ |
|
| Interacting proteins: Q8WXF3 and Q9HBX9 |
Pubmed |
SVM Score :0.0 |
| Anatomic studies have demonstrated that discrete populations of neurons in rat brain express relaxin and relaxin 3 mRNA / peptide , relaxin and relaxin 3 binding sites , and LGR 7 and GPCR 135 mRNAs . ^^^ |
|
| Interacting proteins: Q8WXF3 and Q9HBX9 |
Pubmed |
SVM Score :0.0 |
| Currently , four relaxin peptide family receptors are known : LGR 7 is the relaxin receptor , although it also interacts specifically with relaxin 3 ; LGR 8 is the insulin like factor 3 ( INSL 3 ) receptor ; and GPCR 135 or the somatostatin and angiotensin like peptide receptor ( SALPR ) and GPCR 142 are both specific relaxin 3 receptors . ^^^ |
|
| Interacting proteins: Q8WXF3 and Q9HBX9 |
Pubmed |
SVM Score :0.0 |
| This interaction partly blocks the conserved RXXXRXXI motif identified as a determinant for the interaction with the relaxin receptor LGR 7 and may account for the lower affinity of relaxin 3 relative to relaxin for this receptor . ^^^ |
|
| Interacting proteins: Q8WXF3 and Q9HBX9 |
Pubmed |
SVM Score :0.0 |
| Relaxin 3 : improved synthesis strategy and demonstration of its high affinity interaction with the relaxin receptor LGR 7 both in vitro and in vivo . ^^^ Although the highest activity was demonstrated on the human relaxin 3 receptor ( GPCR 135 ) , the peptide also showed high activity on relaxin receptors ( LGR 7 ) from various species and variable activity on the INSL 3 receptor ( LGR 8 ) . ^^^ |
|
| Interacting proteins: Q8WXF3 and Q9HBX9 |
Pubmed |
SVM Score :0.0 |
| In this review it is suggested that the receptors for relaxin ( LGR 7 ) and those for the related peptides insulin like peptide 3 ( LGR 8 ) , relaxin 3 ( GPCR 135 ) , and insulin like peptide 5 ( LGPCR 142 ) be named the relaxin family peptide receptors 1 through 4 ( RXFP 1 4 ) . ^^^ |
|
| Interacting proteins: Q8WXF3 and Q9HBX9 |
Pubmed |
SVM Score :0.0 |
| In addition , relaxin 3 has demonstrated affinity and functional agonism for GPCR 142 ( GPR 100 ) and LGR 7 receptors in vitro . ^^^ |
|
| Interacting proteins: Q8WXF3 and Q9HBX9 |
Pubmed |
SVM Score :0.0 |
| Mouse relaxin and mouse relaxin 3 peptides engineered by recombinant LVs were biologically active as shown by stimulation of cAMP from both THP 1 and 293T cells stably expressing relaxin receptor LGR 7 and by up regulation of MMP 2 activity from primary C57BL / 6 lung cell cultures . ^^^ |
|
| Interacting proteins: Q8WXF3 and Q9HBX9 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WXF3 and Q9HBX9 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WXF3 and Q9HBX9 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WXF3 and Q9HBX9 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WXF3 and Q9HBX9 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HBX9 and Q8WXF3 |
Pubmed |
SVM Score :0.0 |
| Relaxin 3 / insulin like peptide 5 chimeric peptide , a selective ligand for G protein coupled receptor ( GPCR ) 135 and GPCR 142 over leucine rich repeat containing G protein coupled receptor 7 . ^^^ |
|
| Interacting proteins: Q9HBX9 and Q8WXF3 |
Pubmed |
SVM Score :0.0 |
| Chem . 278 , 50754 50764 ) , we present the case that relaxin 3 , which has previously been shown to bind to the relaxin receptor LGR 7 , is most likely the endogenous ligand for GPCR 135 . ^^^ |
|
| Interacting proteins: Q9HBX9 and Q8WXF3 |
Pubmed |
SVM Score :0.0 |
| Relaxin 3 has previously been shown to bind and activate the LGR 7 relaxin receptor . ^^^ |
|
| Interacting proteins: Q9HBX9 and Q8WXF3 |
Pubmed |
SVM Score :0.0 |
| However , unlike relaxin 3 , which is also a potent agonist for GPCR 135 and LGR 7 , INSL 5 does not activate either GPCR 135 or LGR 7 . ^^^ |
|
| Interacting proteins: Q9HBX9 and Q8WXF3 |
Pubmed |
SVM Score :0.0 |
| Relaxin 3 binds with high affinity to the LGR 7 receptor and to the previously orphan G protein coupled receptor GPCR 135 . ^^^ |
|
| Interacting proteins: Q9HBX9 and Q8WXF3 |
Pubmed |
SVM Score :0.0 |
| In addition , INSL 3 and relaxin 3 were found to be specific ligands for LGR 8 and LGR 7 , respectively . ^^^ |
|
| Interacting proteins: Q9HBX9 and Q8WXF3 |
Pubmed |
SVM Score :0.0 |
| Recent studies have demonstrated that relaxin 3 will bind to and activate human LGR 7 , but not LGR 8 , in vitro . ^^^ |
|
| Interacting proteins: Q9HBX9 and Q8WXF3 |
Pubmed |
SVM Score :0.0 |
| In conclusion , both LGR 7 and LGR 8 are expressed in activated HSCs and cirrhotic liver , suggesting that relaxin , InsL 3 , or relaxin 3 may be useful in the treatment of hepatic fibrosis . . ^^^ |
|
| Interacting proteins: Q9HBX9 and Q8WXF3 |
Pubmed |
SVM Score :0.0 |
| Discrete neuronal populations in brain express relaxin and relaxin 3 , and molecular studies have identified former orphan , G protein coupled receptors LGR 7 and GPCR 135 as their native receptors . ^^^ |
|
| Interacting proteins: Q9HBX9 and Q8WXF3 |
Pubmed |
SVM Score :0.0 |
| Anatomic studies have demonstrated that discrete populations of neurons in rat brain express relaxin and relaxin 3 mRNA / peptide , relaxin and relaxin 3 binding sites , and LGR 7 and GPCR 135 mRNAs . ^^^ |
|
| Interacting proteins: Q9HBX9 and Q8WXF3 |
Pubmed |
SVM Score :0.0 |
| Currently , four relaxin peptide family receptors are known : LGR 7 is the relaxin receptor , although it also interacts specifically with relaxin 3 ; LGR 8 is the insulin like factor 3 ( INSL 3 ) receptor ; and GPCR 135 or the somatostatin and angiotensin like peptide receptor ( SALPR ) and GPCR 142 are both specific relaxin 3 receptors . ^^^ |
|
| Interacting proteins: Q9HBX9 and Q8WXF3 |
Pubmed |
SVM Score :0.0 |
| This interaction partly blocks the conserved RXXXRXXI motif identified as a determinant for the interaction with the relaxin receptor LGR 7 and may account for the lower affinity of relaxin 3 relative to relaxin for this receptor . ^^^ |
|
| Interacting proteins: Q9HBX9 and Q8WXF3 |
Pubmed |
SVM Score :0.0 |
| Relaxin 3 : improved synthesis strategy and demonstration of its high affinity interaction with the relaxin receptor LGR 7 both in vitro and in vivo . ^^^ Although the highest activity was demonstrated on the human relaxin 3 receptor ( GPCR 135 ) , the peptide also showed high activity on relaxin receptors ( LGR 7 ) from various species and variable activity on the INSL 3 receptor ( LGR 8 ) . ^^^ |
|
| Interacting proteins: Q9HBX9 and Q8WXF3 |
Pubmed |
SVM Score :0.0 |
| In this review it is suggested that the receptors for relaxin ( LGR 7 ) and those for the related peptides insulin like peptide 3 ( LGR 8 ) , relaxin 3 ( GPCR 135 ) , and insulin like peptide 5 ( LGPCR 142 ) be named the relaxin family peptide receptors 1 through 4 ( RXFP 1 4 ) . ^^^ |
|
| Interacting proteins: Q9HBX9 and Q8WXF3 |
Pubmed |
SVM Score :0.0 |
| In addition , relaxin 3 has demonstrated affinity and functional agonism for GPCR 142 ( GPR 100 ) and LGR 7 receptors in vitro . ^^^ |
|
| Interacting proteins: Q9HBX9 and Q8WXF3 |
Pubmed |
SVM Score :0.0 |
| Mouse relaxin and mouse relaxin 3 peptides engineered by recombinant LVs were biologically active as shown by stimulation of cAMP from both THP 1 and 293T cells stably expressing relaxin receptor LGR 7 and by up regulation of MMP 2 activity from primary C57BL / 6 lung cell cultures . ^^^ |
|
| Interacting proteins: Q9HBX9 and Q8WXF3 |
Pubmed |
SVM Score :0.0 |
| The cognate ligands for the receptors have been identified : relaxin for RXFP 1 ; INSL 3 for RXFP 2 ; relaxin 3 for RXFP 3 and INSL 5 for RXFP 4 . ^^^ |
|
| Interacting proteins: Q9HBX9 and Q8WXF3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HBX9 and Q8WXF3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HBX9 and Q8WXF3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HBX9 and Q8WXF3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HBX9 and Q8WXF3 |
Pubmed |
SVM Score :0.0 |
| NA |
|