| Interacting proteins: P04808 and Q9HBX9 |
Pubmed |
SVM Score :0.0 |
| However , Lgr 7 deficient males do not exhibit abnormalities in the testes or prostate as seen in Rln 1 knockout mice . ^^^ Double mutant males have normal sized prostate and testes , suggesting that Lgr 8 does not account for differences in Rln 1 / and Lgr 7 / phenotypes . ^^^ |
|
| Interacting proteins: P04808 and Q9HBX9 |
Pubmed |
SVM Score :0.0 |
| The phenotypic effects of deficiency for Lgr 7 and Lgr 8 receptors , transgenic overexpression of Rln 1 and Insl 3 , and different combinations of these mutations in mice were analyzed . ^^^ However , Lgr 7 deficient males do not exhibit abnormalities of male reproductive organs as seen in Rln 1 knockout mice . ^^^ Double mutant males deficient for Lgr 7 and Lgr 8 have a normal prostate , suggesting that Lgr 8 does not account for differences in Rln 1 / and Lgr 7 / phenotypes . ^^^ Rln 1 transgenic females exhibited increased nipple size , whereas Rln 1 transgenic females deficient in Lgr 7 had undeveloped nipples , indicating that Lgr 7 is the only receptor for relaxin that mediates this effect . ^^^ Transgenic overexpression of Rln 1 does not affect gonadal descent in females , and transgenic overexpression of Insl 3 does not rescue the mutant phenotype of Lgr 7 deficient mice , suggesting the non overlapping functions of two signaling pathways . ^^^ |
|
| Interacting proteins: P04808 and Q9HBX9 |
Pubmed |
SVM Score :0.0 |
| Deletion of the relaxin receptor , leucine rich repeats containing G protein coupled receptor 7 , Lgr 7 , in Tg ( Rln 1 ) animals abrogated the development of enlarged nipples in females , indicating that relaxin exerts its effect through Lgr 7 alone . ^^^ |
|
| Interacting proteins: P04808 and Q9HBX9 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HBX9 and P04808 |
Pubmed |
SVM Score :0.0 |
| However , Lgr 7 deficient males do not exhibit abnormalities in the testes or prostate as seen in Rln 1 knockout mice . ^^^ Double mutant males have normal sized prostate and testes , suggesting that Lgr 8 does not account for differences in Rln 1 / and Lgr 7 / phenotypes . ^^^ |
|
| Interacting proteins: Q9HBX9 and P04808 |
Pubmed |
SVM Score :0.0 |
| The phenotypic effects of deficiency for Lgr 7 and Lgr 8 receptors , transgenic overexpression of Rln 1 and Insl 3 , and different combinations of these mutations in mice were analyzed . ^^^ However , Lgr 7 deficient males do not exhibit abnormalities of male reproductive organs as seen in Rln 1 knockout mice . ^^^ Double mutant males deficient for Lgr 7 and Lgr 8 have a normal prostate , suggesting that Lgr 8 does not account for differences in Rln 1 / and Lgr 7 / phenotypes . ^^^ Rln 1 transgenic females exhibited increased nipple size , whereas Rln 1 transgenic females deficient in Lgr 7 had undeveloped nipples , indicating that Lgr 7 is the only receptor for relaxin that mediates this effect . ^^^ Transgenic overexpression of Rln 1 does not affect gonadal descent in females , and transgenic overexpression of Insl 3 does not rescue the mutant phenotype of Lgr 7 deficient mice , suggesting the non overlapping functions of two signaling pathways . ^^^ |
|
| Interacting proteins: Q9HBX9 and P04808 |
Pubmed |
SVM Score :0.0 |
| Deletion of the relaxin receptor , leucine rich repeats containing G protein coupled receptor 7 , Lgr 7 , in Tg ( Rln 1 ) animals abrogated the development of enlarged nipples in females , indicating that relaxin exerts its effect through Lgr 7 alone . ^^^ |
|
| Interacting proteins: Q9HBX9 and P04808 |
Pubmed |
SVM Score :0.0 |
| NA |
|