| Interacting proteins: Q9HBM0 and Q13402 |
Pubmed |
SVM Score :0.0 |
| Vezatin , a novel transmembrane protein , bridges myosin VIIA to the cadherin catenins complex . ^^^ Here we show that the C terminal FERM domain of myosin VIIA binds to a novel transmembrane protein , vezatin , which we identified by a yeast two hybrid screen . ^^^ Vezatin is a ubiquitous protein of adherens cell cell junctions , where it interacts with both myosin VIIA and the cadherin catenins complex . ^^^ Taken together , these data suggest that myosin VIIA , anchored by vezatin to the cadherin catenins complex , creates a tension force between adherens junctions and the actin cytoskeleton that is expected to strengthen cell cell adhesion . ^^^ In myosin VIIA defective mutants , inactivity of the vezatin myosin VIIA complex at both sites could account for splaying out of the hair cell stereocilia . . ^^^ |
|
| Interacting proteins: Q9HBM0 and Q13402 |
Pubmed |
SVM Score :0.0 |
| Mutations in MyoVIIA , another unconventional myosin protein , also lead to deafness , and MyoVIIA interacts with E cadherin through a membrane protein called vezatin . ^^^ |
|
| Interacting proteins: Q9HBM0 and Q13402 |
Pubmed |
SVM Score :0.0 |
| Unconventional myosin VIIa and vezatin , two proteins crucial for Listeria entry into epithelial cells . ^^^ We have recently identified an unconventional myosin , myosin VIIa and its ligand vezatin , at the adherens junctions of polarized epithelial cells . ^^^ Here , we demonstrate by pharmacological and genetic approaches that both myosin VIIa and vezatin are crucial for Listeria internalization . ^^^ |
|