| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| Here we show that the previously described orphan G protein coupled receptor FM 3 ( ref . 15 ) and a newly discovered one ( FM 4 ) are cognate receptors for NMU . ^^^ |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| Recently , GPR66 / FM 3 ( NmU R 1 ) was identified as a specific receptor for neuromedin U . ^^^ A BLAST search of the GenBank ( TM ) genomic database using the NmU R 1 cDNA sequence revealed a human genomic fragment encoding a G protein coupled receptor that we designated NmU R 2 based on its homology to NmU R 1 . ^^^ |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NMU binds to GPR 66 expressing cells with high specificity to induce intracellular calcium mobilization . ^^^ |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| The interaction of the CC chemokine RANTES with its cell surface receptors transduces multiple intracellular signals : low concentrations of RANTES ( 1 to 10 nM ) stimulate G protein coupled receptor ( GPCR ) activity , and higher concentrations ( 1 microM ) activate a phosphotyrosine kinase ( PTK ) dependent pathway . ^^^ |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| Recently , two human G protein coupled receptors have been identified as NmU specific receptors , NmU R 1 and NmU R 2 , which share 55 % amino acid identity . ^^^ Mouse NmU R 1 and mouse NmU R 2 are 79 and 81 % identical to their respective human homologues . ^^^ Expression of NmU R 1 was mainly observed in testis , gastrointestinal ( GI ) tract , and immune system , while NmU R 2 was primarily expressed in brain tissues . ^^^ |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| Significantly , only AML cells expressed the cognate receptor of NmU , NMU1R , suggesting the presence of a novel autocrine loop . ^^^ Exposing Indo 1 labeled K 562 cells to NmU induced an intracellular Ca ( ++ ) flux consistent with engagement of the NMU1R . ^^^ Combined , these results suggest that NmU expression is related to Myb and that the NmU / NMU1R axis constitutes a previously unknown growth promoting autocrine loop in myeloid leukemia cells . . ^^^ |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| RATIONALE : Neuromedin U ( NmU ) is an agonist at NMU1R and NMU2R . ^^^ OBJECTIVES : To investigate the CNS role of NmU by mapping NMU1R and NMU2R mRNA and measuring the behavioural , endocrine , neurochemical and c fos response to intracerebroventricular ( i . c . v . ) NmU . ^^^ METHODS : Binding affinity and functional potency of rat NmU was determined at human NMU1R and NMU2R . ^^^ RESULTS : NmU bound to NMU1R ( K ( 1 ) , 0 . 11+ / 0 . 02 nM ) and NMU2R ( K ( 1 ) , 0 . 21+ / 0 . 05 nM ) with equal affinity and was equally active at NMU1R ( EC ( 50 ) , 1 . 25+ / 0 . 05 nM ) and NMU2R ( EC ( 50 ) , 1 . 10+ / 0 . 20 nM ) in a functional assay . ^^^ |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| Recently , two G protein coupled receptors for NmU ( NmU1R and NmU2R ) have been cloned having approximately 50 % homology . ^^^ Exposure of these cells to NmU isopeptides resulted in an increase in intracellular [ Ca2+ ] 1 release ( EC 50 value of 0 . 50 + / 0 . 10 nmol / l ) and inositol phosphate formation ( EC 50 1 . 6 + / 0 . 2 and 1 . 50 + / 0 . 4 nmol / l for NmU1R and NmU2R respectively ) . ^^^ |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| These receptors have approximately 50 % amino acid homology , and , at least in mammalian species , NmU R 1 and NmU R 2 are expressed predominantly in the periphery and central nervous system , respectively . ^^^ |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NMU interacts with two G protein coupled receptors , NMU R 1 and NMU R 2 . ^^^ Whereas NMU R 2 localizes predominantly to nerve cells , NMU R 1 is expressed in peripheral tissues including lymphocytes and monocytes , suggesting a role of NMU in immunoregulation . ^^^ NMU R 1 was highly expressed in primary mast cells , and NMU induced Ca ( 2+ ) mobilization and degranulation in peritoneal mast cells . ^^^ |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| Neuromedin S ( NMS ) was recently isolated from the brains of humans , mice and rats as an endogenous ligand for the orphan G protein coupled receptors FM 3 and FM 4 , which have been identified as neuromedin U ( NMU ) receptors 1 and 2 , respectively . ^^^ |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NMU interacts with two G protein coupled receptors , NMU R 1 and NMU R 2 . ^^^ Although NMU R 2 is expressed in a specific region of the brain , NMU R 1 is expressed in various peripheral tissues , including immune and hematopoietic cells . ^^^ NMU R 1 was highly expressed in the eosinophil cell line , and NMU directly induced Ca ( 2+ ) mobilization and extracellular / signal regulated kinase phosphorylation . ^^^ Furthermore , NMU R 1 was also expressed in human peripheral blood eosinophils , and NMU induced cell adhesion in a dose dependent manner . ^^^ |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| Both NMU and its receptors , NMUR 1 and NMUR 2 , were expressed in the pituitary gland . ^^^ |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| However , the NMU receptor NMU R 1 has been shown to be expressed in immune cells and NMU promotes mast cell dependent inflammation . ^^^ Both NMU and NMU R 1 were expressed in wild type peritoneal macrophages , and treatment with LPS resulted in up regulation of NMU but down regulation of NMU R 1 expression , however , no down regulation of NMU R 1 was observed in NMU deficient macrophages where LPS induced IL 6 production was severely reduced . ^^^ These data suggest that LPS induced IL 6 expression is partly dependent on autocrine / paracrine activation of the NMU NMU R 1 signals in macrophages . . ^^^ |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| By initiating TRHR 1 G protein coupled receptor ( GPCR ) and dissociated alphabetagamma complex , TRH ( 200 nM ) activates tyrosine residues at Tyr 845 ( a known target for Src ) and Tyr 1068 in the EGF receptor complex of an immortalized mouse beta cell line , betaTC 6 . ^^^ |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| Thus , the 380 nm absorbance arises from an on pathway intermediate in GPCR activation and does not result from early Schiff base hydrolysis . ^^^ |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48645 and Q9HB89 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| Recently , GPR66 / FM 3 ( NmU R 1 ) was identified as a specific receptor for neuromedin U . ^^^ A BLAST search of the GenBank ( TM ) genomic database using the NmU R 1 cDNA sequence revealed a human genomic fragment encoding a G protein coupled receptor that we designated NmU R 2 based on its homology to NmU R 1 . ^^^ |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| Recently , two human G protein coupled receptors have been identified as NmU specific receptors , NmU R 1 and NmU R 2 , which share 55 % amino acid identity . ^^^ Mouse NmU R 1 and mouse NmU R 2 are 79 and 81 % identical to their respective human homologues . ^^^ Expression of NmU R 1 was mainly observed in testis , gastrointestinal ( GI ) tract , and immune system , while NmU R 2 was primarily expressed in brain tissues . ^^^ |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| These receptors have approximately 50 % amino acid homology , and , at least in mammalian species , NmU R 1 and NmU R 2 are expressed predominantly in the periphery and central nervous system , respectively . ^^^ |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NMU interacts with two G protein coupled receptors , NMU R 1 and NMU R 2 . ^^^ Whereas NMU R 2 localizes predominantly to nerve cells , NMU R 1 is expressed in peripheral tissues including lymphocytes and monocytes , suggesting a role of NMU in immunoregulation . ^^^ NMU R 1 was highly expressed in primary mast cells , and NMU induced Ca ( 2+ ) mobilization and degranulation in peritoneal mast cells . ^^^ |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NMU interacts with two G protein coupled receptors , NMU R 1 and NMU R 2 . ^^^ Although NMU R 2 is expressed in a specific region of the brain , NMU R 1 is expressed in various peripheral tissues , including immune and hematopoietic cells . ^^^ NMU R 1 was highly expressed in the eosinophil cell line , and NMU directly induced Ca ( 2+ ) mobilization and extracellular / signal regulated kinase phosphorylation . ^^^ Furthermore , NMU R 1 was also expressed in human peripheral blood eosinophils , and NMU induced cell adhesion in a dose dependent manner . ^^^ |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| Significantly , only AML cells expressed the cognate receptor of NmU , NMU1R , suggesting the presence of a novel autocrine loop . ^^^ Exposing Indo 1 labeled K 562 cells to NmU induced an intracellular Ca ( ++ ) flux consistent with engagement of the NMU1R . ^^^ Combined , these results suggest that NmU expression is related to Myb and that the NmU / NMU1R axis constitutes a previously unknown growth promoting autocrine loop in myeloid leukemia cells . . ^^^ |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| However , the NMU receptor NMU R 1 has been shown to be expressed in immune cells and NMU promotes mast cell dependent inflammation . ^^^ Both NMU and NMU R 1 were expressed in wild type peritoneal macrophages , and treatment with LPS resulted in up regulation of NMU but down regulation of NMU R 1 expression , however , no down regulation of NMU R 1 was observed in NMU deficient macrophages where LPS induced IL 6 production was severely reduced . ^^^ These data suggest that LPS induced IL 6 expression is partly dependent on autocrine / paracrine activation of the NMU NMU R 1 signals in macrophages . . ^^^ |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| Here we show that the previously described orphan G protein coupled receptor FM 3 ( ref . 15 ) and a newly discovered one ( FM 4 ) are cognate receptors for NMU . ^^^ |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| Neuromedin S ( NMS ) was recently isolated from the brains of humans , mice and rats as an endogenous ligand for the orphan G protein coupled receptors FM 3 and FM 4 , which have been identified as neuromedin U ( NMU ) receptors 1 and 2 , respectively . ^^^ |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| The interaction of the CC chemokine RANTES with its cell surface receptors transduces multiple intracellular signals : low concentrations of RANTES ( 1 to 10 nM ) stimulate G protein coupled receptor ( GPCR ) activity , and higher concentrations ( 1 microM ) activate a phosphotyrosine kinase ( PTK ) dependent pathway . ^^^ |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| By initiating TRHR 1 G protein coupled receptor ( GPCR ) and dissociated alphabetagamma complex , TRH ( 200 nM ) activates tyrosine residues at Tyr 845 ( a known target for Src ) and Tyr 1068 in the EGF receptor complex of an immortalized mouse beta cell line , betaTC 6 . ^^^ |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| Thus , the 380 nm absorbance arises from an on pathway intermediate in GPCR activation and does not result from early Schiff base hydrolysis . ^^^ |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| NMU binds to GPR 66 expressing cells with high specificity to induce intracellular calcium mobilization . ^^^ |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| RATIONALE : Neuromedin U ( NmU ) is an agonist at NMU1R and NMU2R . ^^^ OBJECTIVES : To investigate the CNS role of NmU by mapping NMU1R and NMU2R mRNA and measuring the behavioural , endocrine , neurochemical and c fos response to intracerebroventricular ( i . c . v . ) NmU . ^^^ METHODS : Binding affinity and functional potency of rat NmU was determined at human NMU1R and NMU2R . ^^^ RESULTS : NmU bound to NMU1R ( K ( 1 ) , 0 . 11+ / 0 . 02 nM ) and NMU2R ( K ( 1 ) , 0 . 21+ / 0 . 05 nM ) with equal affinity and was equally active at NMU1R ( EC ( 50 ) , 1 . 25+ / 0 . 05 nM ) and NMU2R ( EC ( 50 ) , 1 . 10+ / 0 . 20 nM ) in a functional assay . ^^^ |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| Recently , two G protein coupled receptors for NmU ( NmU1R and NmU2R ) have been cloned having approximately 50 % homology . ^^^ Exposure of these cells to NmU isopeptides resulted in an increase in intracellular [ Ca2+ ] 1 release ( EC 50 value of 0 . 50 + / 0 . 10 nmol / l ) and inositol phosphate formation ( EC 50 1 . 6 + / 0 . 2 and 1 . 50 + / 0 . 4 nmol / l for NmU1R and NmU2R respectively ) . ^^^ |
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| Interacting proteins: Q9HB89 and P48645 |
Pubmed |
SVM Score :0.0 |
| Both NMU and its receptors , NMUR 1 and NMUR 2 , were expressed in the pituitary gland . ^^^ |
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