| Interacting proteins: Q9HAW4 and Q99638 |
Pubmed |
SVM Score :0.0 |
| Moreover , Claspin interacts with the checkpoint proteins ATR and Rad 9 . ^^^ Given that both the ATR and Rad 9 Rad1 Hus 1 complexes are involved in Chk 1 activation , it is possible that Claspin works as an adaptor molecule bringing these molecules together . ^^^ |
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| Interacting proteins: Q9HAW4 and Q99638 |
Pubmed |
SVM Score :0.0 |
| ATR , Claspin and the Rad 9 Rad1 Hus 1 complex regulate Chk 1 and Cdc25A in the absence of DNA damage . ^^^ ATR , with Claspin and the Rad 9 Rad1 Hus 1 complex , activates Chk 1 after DNA damage . ^^^ Here , we show that during physiological S phase the regulation of the Chk 1 Cdc25A pathway depends on ATR , Claspin , Rad 9 , and Hus 1 . ^^^ Furthermore , siRNA mediated depletion of Claspin , Rad 9 and Hus 1 also stabilized Cdc25A . ^^^ |
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| Interacting proteins: Q9HAW4 and Q99638 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of Xenopus Rad 1 and Hus 1 defines a readout for ATR activation that is independent of Claspin and the Rad 9 carboxy terminus . ^^^ Interestingly , phosphorylation of Rad 1 is independent of Claspin and the Rad 9 carboxy terminus , both of which are required for Chk 1 phosphorylation . ^^^ |
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