| Interacting proteins: Q9HAW4 and P38398 |
Pubmed |
SVM Score :0.0 |
| Human Claspin works with BRCA 1 to both positively and negatively regulate cell proliferation . ^^^ DNA damage induces the formation of a complex between Claspin and BRCA 1 , a second regulator of Chk 1 activation . ^^^ Claspin was found to control BRCA 1 phosphorylation on serine 1524 , a site whose phosphorylation is controlled by the ATR pathway . ^^^ These results are consistent with a model in which ATR regulates Claspin phosphorylation in response to DNA damage and replication stress resulting in recruitment and phosphorylation of BRCA 1 . ^^^ BRCA 1 and Claspin then function to activate the tumor suppressor Chk 1 . ^^^ |
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| Interacting proteins: Q9HAW4 and P38398 |
Pubmed |
SVM Score :0.0 |
| Significantly , removal of Claspin from egg extracts only partially abrogates the activation of Chk 1 in response to chromatin with DSBs , whereas depletion of both Claspin and BRCA 1 completely abolishes this activation . ^^^ Conversely , neither phosphorylation of Claspin on these sites nor the presence of BRCA 1 is necessary for activation of Chk 1 in response to stalled replication forks . ^^^ |
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