| Interacting proteins: Q9HAU4 and P12757 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HAU4 and P12757 |
Pubmed |
SVM Score :0.0 |
| We also studied the involvement of Smad ubiquitination regulatory factor 2 ( Smurf 2 ) in ubiquitination of SnoN protein . ^^^ |
|
| Interacting proteins: Q9HAU4 and P12757 |
Pubmed |
SVM Score :0.0 |
| TGF beta also induces the association of Smurf 2 with the transcriptional co repressor SnoN and we show that Smad 2 can function to mediate this interaction . ^^^ This allows Smurf 2 HECT domain to target SnoN for ubiquitin mediated degradation by the proteasome . ^^^ |
|
| Interacting proteins: Q9HAU4 and P12757 |
Pubmed |
SVM Score :0.0 |
| Smurf 2 induces ubiquitin dependent degradation of SnoN , since it appears to be located close to SnoN through binding to the linker region of Smad 2 . ^^^ |
|
| Interacting proteins: Q9HAU4 and P12757 |
Pubmed |
SVM Score :0.0 |
| It has been shown that Smad 3 recruits two types of Ub E 3 ligases , Smurf 2 and the Anaphase Promoting Complex ( APC ) , to mediate SnoN ubiquitination , thereby enhancing SnoN degradation . ^^^ |
|
| Interacting proteins: Q9HAU4 and P12757 |
Pubmed |
SVM Score :0.0 |
| However , in contrast with Smurf 2 , NEDD 4 2 failed to induce ubiquitination of SnoN ( Ski related novel protein N ) , although NEDD 4 2 bound to SnoN via Smad 2 more strongly than Smurf 2 . ^^^ |
|
| Interacting proteins: Q9HAU4 and P12757 |
Pubmed |
SVM Score :0.0 |
| Smad 3 / chondrocytes lacked compensatory increases in Smad 2 , Smad 4 , TGFRII , Sno , or Smurf 2 and had reduced expression of TGF beta 1 and TGFRI . ^^^ |
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