| Interacting proteins: Q9HAP2 and Q9UH92 |
Pubmed |
SVM Score :0.0 |
| MondoA and Mlx associate in vivo , and surprisingly , they are localized primarily to the cytoplasm of cultured mammalian cells . ^^^ Treatment of cells with the nuclear export inhibitor leptomycin B results in the nuclear accumulation of MondoA and Mlx , demonstrating that they shuttle between the cytoplasmic and nuclear compartments rather than having exclusively cytoplasmic localization . ^^^ MondoA preferentially forms heterodimers with Mlx , and this heterocomplex can bind to , and activate transcription from , CACGTG E boxes when targeted to the nucleus via a heterologous nuclear localization signal . ^^^ |
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| Interacting proteins: Q9HAP2 and Q9UH92 |
Pubmed |
SVM Score :0.0 |
| A novel heterodimerization domain , CRM 1 , and 14 3 3 control subcellular localization of the MondoA Mlx heterocomplex . ^^^ Among members of the bHLHZip family of transcriptional regulators , MondoA and Mlx have the unique property of cytoplasmic localization . ^^^ We have proposed that MondoA Mlx heterodimers accumulate in the nucleus in response to extracellular cues . ^^^ Our previous work implicated heterodimerization between MondoA and Mlx and a conserved domain in the N terminus of MondoA as important determinants of MondoA Mlx subcellular localization . ^^^ MondoA and Mlx share sequence similarity in their bHLHZip domains and C termini . ^^^ |
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| Interacting proteins: Q9HAP2 and Q9UH92 |
Pubmed |
SVM Score :0.0 |
| The glucose response was rescued by adding exogenous wild type Mlx or ChREBP , but not MondoA , a paralog of ChREBP that can also form a heterodimer with Mlx . ^^^ |
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| Interacting proteins: Q9HAP2 and Q9UH92 |
Pubmed |
SVM Score :0.0 |
| MondoA Mlx heterodimers are candidate sensors of cellular energy status : mitochondrial localization and direct regulation of glycolysis . ^^^ However , unlike Myc , MondoA and its binding partner Mlx localize to the cytoplasm , suggesting tight regulation of their nuclear function . ^^^ We show here that endogenous MondoA and Mlx associate with mitochondria in primary skeletal muscle cells and erythroblast K 562 cells . ^^^ |
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| Interacting proteins: Q9HAP2 and Q9UH92 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HAP2 and Q9UH92 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HAP2 and Q9UH92 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HAP2 and Q9UH92 |
Pubmed |
SVM Score :0.0 |
| NA |
|