| Interacting proteins: Q9H9A7 and P54132 |
Pubmed |
SVM Score :0.6612553 |
| Here , using highly purified human proteins , we show that BLAP 75 associates independently with both Topo IIIalpha and BLM . 0.6612553^^^ |
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| Interacting proteins: Q9H9A7 and P54132 |
Pubmed |
SVM Score :0.0 |
| Here we demonstrate that BLAP 75 , a novel protein containing a putative OB fold nucleic acid binding domain , is an integral component of BLM complexes , and is essential for their stability in vivo . ^^^ Consistent with a role in BLM mediated processes , BLAP 75 colocalizes with BLM in subnuclear foci in response to DNA damage , and its depletion impairs the recruitment of BLM to these foci . ^^^ Depletion of BLAP 75 by siRNA also results in deficient phosphorylation of BLM during mitosis , as well as defective cell proliferation . ^^^ Moreover , cells depleted of BLAP 75 display an increased level of sister chromatid exchange , similar to cells depleted of BLM by siRNA . ^^^ Thus , BLAP 75 is an essential component of the BLM associated cellular machinery that maintains genome integrity . . ^^^ |
|
| Interacting proteins: Q9H9A7 and P54132 |
Pubmed |
SVM Score :0.0 |
| BLM forms part of a multienzyme complex including topoisomerase IIIalpha , replication protein A and a newly identified factor called BLAP 75 . ^^^ |
|
| Interacting proteins: Q9H9A7 and P54132 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9H9A7 and P54132 |
Pubmed |
SVM Score :0.0 |
| NA |
|