| Interacting proteins: Q9H4P4 and P21860 |
Pubmed |
SVM Score :1.0004069 |
| Here , we present evidence that ErbB 3 is degraded by proteasomes , and that Nrdp 1 ( referred to as FLRF in mice ) associates with ErbB 3 and stimulates its ubiquitination and degradation by proteasomes . 1.0004069^^^ |
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| Interacting proteins: Q9H4P4 and P21860 |
Pubmed |
SVM Score :0.0 |
| Nrdp 1 interacts specifically with the neuregulin receptors ErbB 3 and ErbB 4 and not with epidermal growth factor receptor or ErbB 2 . ^^^ When coexpressed in COS 7 cells , Nrdp 1 mediates the redistribution of ErbB 3 from the cell surface to intracellular compartments and induces the suppression of ErbB 3 and ErbB 4 receptor levels but not epidermal growth factor receptor or ErbB 2 levels . ^^^ |
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| Interacting proteins: Q9H4P4 and P21860 |
Pubmed |
SVM Score :0.0 |
| Nrdp 1 is a RING finger containing E 3 ubiquitin ligase that physically interacts with and regulates steady state cellular levels of the ErbB 3 and ErbB 4 receptor tyrosine kinases and has been implicated in the degradation of the inhibitor of apoptosis protein BRUCE . ^^^ |
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| Interacting proteins: Q9H4P4 and P21860 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9H4P4 and P21860 |
Pubmed |
SVM Score :0.0 |
| NA |
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