| Interacting proteins: Q9H1A4 and Q9UJX6 |
Pubmed |
SVM Score :0.0 |
| In order to detect the presence or absence of wild type adenomatous polyposis coli ( APC ) gene protein ( APC ) in human colonic tissues , we immunoaffinity purified two polyclonal rabbit antibodies ( APC 1 and APC 2 ) directed against defined epitopes in the middle and carboxyl regions of APC . ^^^ Thus , western blot analysis employing APC 1 and APC 2 antibodies may be used to evaluate the absence or presence of wild type APC . ^^^ |
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| Interacting proteins: Q9H1A4 and Q9UJX6 |
Pubmed |
SVM Score :0.0 |
| High avidity rabbit polyclonal antibodies were produced against synthetic peptides corresponding to amino acids 1865 1881 ( APC 1 ) and to amino acids 1336 1350 ( APC 2 ) in APC ' s 2844 amino acid sequence . ^^^ Proteolytic digestion of high salt extracts increased antibody reactivity toward both epitopes , suggesting that APC 1 and APC 2 antigenic sites are partially concealed due to APC ' s involvement in multiprotein complexes . ^^^ |
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| Interacting proteins: Q9H1A4 and Q9UJX6 |
Pubmed |
SVM Score :0.0 |
| Macrophages ( M phi ) as well as dendritic cells ( DCs ) can undergo Th 1 or Th 2 like polarization ; APC 1 and APC 2 thus acquire the capacity to drive the development of naive T cells and the reactivation of resting T cells towards either a Th 1 or a Th 2 phenotype , respectively . ^^^ |
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| Interacting proteins: Q9H1A4 and Q9UJX6 |
Pubmed |
SVM Score :0.0 |
| Drosophila Apc 1 and Apc 2 regulate Wingless transduction throughout development . ^^^ The two Drosophila homologs of APC ( Apc 1 and Apc 2 ) appear to have predominantly different tissue distributions , different subcellular localizations and mutually exclusive phenotypes upon inactivation . ^^^ Together , these results reveal that the combined activity of Apc 1 and Apc 2 allows a tight regulation of transcriptional activation by beta catenin and suggest that APC proteins are required for the regulation of Wnt transduction in all cells . . ^^^ |
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| Interacting proteins: Q9H1A4 and Q9UJX6 |
Pubmed |
SVM Score :0.0 |
| Drosophila APC 2 and APC 1 have overlapping roles in the larval brain despite their distinct intracellular localizations . ^^^ In addition they accumulate with APC 2 and APC 1 in nerves formed by axons of the progeny of each neuroblast ganglion mother cell cluster . ^^^ APC 2 and APC 1 localize to very different places when expressed in the larval brain : APC 2 localizes to the cell cortex and APC 1 to centrosomes and microtubules . ^^^ |
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| Interacting proteins: Q9H1A4 and Q9UJX6 |
Pubmed |
SVM Score :0.0 |
| Drosophila APC 2 and APC 1 play overlapping roles in wingless signaling in the embryo and imaginal discs . ^^^ We find that APC 1 and APC 2 play overlapping roles in regulating Wingless signaling in the embryonic epidermis and the imaginal discs . ^^^ |
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| Interacting proteins: Q9H1A4 and Q9UJX6 |
Pubmed |
SVM Score :0.0 |
| Seven core subunit homologs of APC / C ( APC 1 , APC 2 , APC 11 , CDC 16 , CDC 23 , CDC 27 , and DOC 1 ) were identified in the Trypanosoma brucei genome data base . ^^^ |
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| Interacting proteins: Q9H1A4 and Q9UJX6 |
Pubmed |
SVM Score :0.0 |
| We found that the largest subunit , Apc 1 , serves as a scaffold that associates independently with two separable subcomplexes , one that contains Apc 2 ( Cullin ) , Apc 11 ( RING ) , and Doc1 / Apc10 , and another that contains the three TPR subunits ( Cdc 27 , Cdc 16 , and Cdc 23 ) . ^^^ |
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| Interacting proteins: Q9H1A4 and Q9UJX6 |
Pubmed |
SVM Score :0.0 |
| Little is known about the performance of Transbond Plus Self Etching Primer ( TPSEP ) , especially when used with Adhesive Precoated Brackets ( APC 1 and APC 2 ) . ^^^ The aim of this study was to compare the shear bond and rebond strengths and failure sites of APC 1 and APC 2 with a non coated bracket system [ Victory Series ( 5 ) ] using Transbond XT light cured adhesive and TPSEP or 37 percent phosphoric acid as the conditioner . ^^^ The results demonstrated that on dry testing of 120 brackets when applying an occluso gingival load to produce a shear force at the bracket tooth interface , there was no statistically significant difference in the shear bond strength ( SBS ) of APC 1 ( 68 . 4 N ) , APC 2 ( 74 . 9 N ) , and 5 brackets ( 75 . 4 N , control group ) . ^^^ There was also no significant difference in bond failure sites of the APC 1 and APC 2 when compared with the non coated bracket system using Transbond XT light cured adhesive and TPSEP , with bond failure for all groups occurring mainly at the adhesive enamel interface . ^^^ The shear rebond strengths of all bracket types were statistically significantly lower ( P < 0 . 05 ) than their initial SBS ( APC 1 , APC 2 , and 5 : 35 . 9 , 36 . 7 , and 34 . 1 N , respectively ) and the locus of bond failure altered from the adhesive enamel interface to the bracket adhesive interface . ^^^ |
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| Interacting proteins: Q9H1A4 and Q9UJX6 |
Pubmed |
SVM Score :0.0 |
| We generated ovaries and embryos null for both APC 2 and APC 1 , and assessed the consequences of total loss of APC function , allowing us to test several previous hypotheses . ^^^ Surprisingly , although complete loss of APC 1 and APC 2 resulted in strong activation of Wingless signaling , it did not substantially alter cell viability , cadherin based adhesion , spindle morphology , orientation or selection of division plane , as predicted from previous studies . ^^^ |
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| Interacting proteins: Q9H1A4 and Q9UJX6 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9H1A4 and Q9UJX6 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9H1A4 and Q9UJX6 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9H1A4 and Q9UJX6 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9H1A4 and Q9UJX6 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9H1A4 and Q9UJX6 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9H1A4 and Q9UJX6 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9H1A4 and Q9UJX6 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9H1A4 and Q9UJX6 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9H1A4 and Q9UJX6 |
Pubmed |
SVM Score :0.0 |
| NA |
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