| Interacting proteins: Q15699 and Q9H161 |
Pubmed |
SVM Score :0.0 |
| Analysis of the homeodomain sequence shows that Alx 4 belongs to a family of genes that are related to the Drosophila gene aristaless , and includes the mammalian genes Alx 3 , Cart 1 , MHox , and S 8 . ^^^ |
|
| Interacting proteins: Q15699 and Q9H161 |
Pubmed |
SVM Score :0.0 |
| Mouse Alx 3 is a homeobox gene that is related to the Drosophila aristaless gene and to a group of vertebrate genes including Prx 1 , Prx 2 , Cart 1 , and Alx 4 . ^^^ |
|
| Interacting proteins: Q15699 and Q9H161 |
Pubmed |
SVM Score :0.0 |
| Physical and genetic interactions between Alx 4 and Cart 1 . ^^^ Alx 4 and Cart 1 are closely related members of the family of transcription factors that contain the paired type homeodomain . ^^^ Alx 4 and Cart 1 are co expressed at several sites during development , including the craniofacial mesenchyme , the mesenchymal derivatives of neural crest cells in the first branchial arch and the limb bud mesenchyme . ^^^ Because of the molecular similarity and overlapping expression pattern , we have analyzed the functional and genetic relationships between Alx 4 and Cart 1 . ^^^ First , mutation of Cart 1 exacerbates Alx 4 dependent polydactyly in a manner that is dependent on gene dosage . ^^^ |
|
| Interacting proteins: Q15699 and Q9H161 |
Pubmed |
SVM Score :0.0 |
| Its homeodomain was related ( with 65 71 % sequence identity ) to that of human Crx , human Cart 1 , and chick Alx 4 . ^^^ |
|
| Interacting proteins: Q15699 and Q9H161 |
Pubmed |
SVM Score :0.0 |
| Expression and functional studies have shown that a subgroup of these genes , including Prx 1 , Prx 2 , Alx 3 , Alx 4 and Cart 1 , is essential for correct morphogenesis of the limbs and cranium . ^^^ |
|
| Interacting proteins: Q15699 and Q9H161 |
Pubmed |
SVM Score :0.0 |
| Although its target gene remains unknown , gene disruption studies have revealed that Cart 1 plays an important role for craniofacial bone formation as well as limb development by cooperating with another homeoprotein , Alx 4 . ^^^ |
|
| Interacting proteins: Q15699 and Q9H161 |
Pubmed |
SVM Score :0.0 |
| Scapular truncation in triple mutants of Tbx 15 , Alx 4 and Cart 1 indicates essential functions for Alx 4 and Cart 1 in the anterior part of the scapula , as opposed to Gli 3 function being linked to the posterior part . ^^^ |
|
| Interacting proteins: Q9H161 and Q15699 |
Pubmed |
SVM Score :0.0 |
| Analysis of the homeodomain sequence shows that Alx 4 belongs to a family of genes that are related to the Drosophila gene aristaless , and includes the mammalian genes Alx 3 , Cart 1 , MHox , and S 8 . ^^^ |
|
| Interacting proteins: Q9H161 and Q15699 |
Pubmed |
SVM Score :0.0 |
| Mouse Alx 3 is a homeobox gene that is related to the Drosophila aristaless gene and to a group of vertebrate genes including Prx 1 , Prx 2 , Cart 1 , and Alx 4 . ^^^ |
|
| Interacting proteins: Q9H161 and Q15699 |
Pubmed |
SVM Score :0.0 |
| Physical and genetic interactions between Alx 4 and Cart 1 . ^^^ Alx 4 and Cart 1 are closely related members of the family of transcription factors that contain the paired type homeodomain . ^^^ Alx 4 and Cart 1 are co expressed at several sites during development , including the craniofacial mesenchyme , the mesenchymal derivatives of neural crest cells in the first branchial arch and the limb bud mesenchyme . ^^^ Because of the molecular similarity and overlapping expression pattern , we have analyzed the functional and genetic relationships between Alx 4 and Cart 1 . ^^^ First , mutation of Cart 1 exacerbates Alx 4 dependent polydactyly in a manner that is dependent on gene dosage . ^^^ |
|
| Interacting proteins: Q9H161 and Q15699 |
Pubmed |
SVM Score :0.0 |
| Its homeodomain was related ( with 65 71 % sequence identity ) to that of human Crx , human Cart 1 , and chick Alx 4 . ^^^ |
|
| Interacting proteins: Q9H161 and Q15699 |
Pubmed |
SVM Score :0.0 |
| Expression and functional studies have shown that a subgroup of these genes , including Prx 1 , Prx 2 , Alx 3 , Alx 4 and Cart 1 , is essential for correct morphogenesis of the limbs and cranium . ^^^ |
|
| Interacting proteins: Q9H161 and Q15699 |
Pubmed |
SVM Score :0.0 |
| Although its target gene remains unknown , gene disruption studies have revealed that Cart 1 plays an important role for craniofacial bone formation as well as limb development by cooperating with another homeoprotein , Alx 4 . ^^^ |
|
| Interacting proteins: Q9H161 and Q15699 |
Pubmed |
SVM Score :0.0 |
| Scapular truncation in triple mutants of Tbx 15 , Alx 4 and Cart 1 indicates essential functions for Alx 4 and Cart 1 in the anterior part of the scapula , as opposed to Gli 3 function being linked to the posterior part . ^^^ |
|