| Interacting proteins: Q9H0B6 and Q07866 |
Pubmed |
SVM Score :0.0 |
| Of the two characterized gene products , KLC 1 was predominant in neuronal tissues , whereas KLC 2 showed a more ubiquitous pattern of expression . ^^^ |
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| Interacting proteins: Q9H0B6 and Q07866 |
Pubmed |
SVM Score :0.0 |
| In the mouse , two KLC genes , KLC 1 and KLC 2 , had been identified . ^^^ KLC 1 plays a role in neuronal transport , and KLC 2 appears to be more widely expressed . ^^^ In contrast , KLC 1 and KLC 2 can only be detected before meiosis in testis . ^^^ |
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| Interacting proteins: Q9H0B6 and Q07866 |
Pubmed |
SVM Score :0.0 |
| The Caenorhabditis elegans genome has a single KHC , encoded by the unc 116 gene , and two KLCs , encoded by the klc 1 and klc 2 genes . ^^^ We show here that UNC 116 / KHC and KLC 2 form a complex orthologous to conventional kinesin 1 . ^^^ KLC 2 also binds UNC 16 , the C . elegans JIP3 / JSAP1 JNK signaling scaffold protein , and the UNC 14 RUN domain protein . ^^^ The localization of UNC 16 and UNC 14 depends on kinesin 1 ( UNC 116 and KLC 2 ) . ^^^ Furthermore , mutations in unc 16 , klc 2 , unc 116 , and unc 14 all alter the localization of cargos containing synaptic vesicle markers . ^^^ |
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