| Interacting proteins: Q9GZV9 and P21802 |
Pubmed |
SVM Score :0.0 |
| Corroborating these important roles , mutations of two members of the FGFR family ( FGFR 1 and FGFR 2 ) are associated with human disorders of limb patterning ; in addition , mutations of FGFR 3 and FGF 23 affect growth of the limb bones . ^^^ |
|
| Interacting proteins: Q9GZV9 and P21802 |
Pubmed |
SVM Score :0.0 |
| FGF 23 ( R179Q ) bound to and activated FGFR 2 , a prominent FGFR expressed in OK E cells . ^^^ Expression of FGFR 2 ( DN ) , which suppresses the major FGFR mediated signal through the FRS2alpha ERK pathway , reversed the function of FGF 23 ( R179Q ) . ^^^ When FGF 23 ( R179Q ) was applied to the basolateral side of polarized OK E cells , regardless of the FGFR 2 ( DN ) expression , the apical Pi uptake decreased significantly . ^^^ |
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