| Interacting proteins: Q9BZW8 and P09326 |
Pubmed |
SVM Score :0.0 |
| We identified amino acid residues in the extracellular domain of h2B4 that are involved in interacting with CD 48 . ^^^ Binding of CD 48 Fc fusion protein to RNK 16 cells stably transfected with wild type and a double mutant Lys ( 68 ) Ala Glu ( 70 ) Ala h2B4 further demonstrated that Lys ( 68 ) and Glu ( 70 ) in the 5 domain of h2B4 are essential for 2B4 / CD48 interaction . ^^^ |
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| Interacting proteins: Q9BZW8 and P09326 |
Pubmed |
SVM Score :0.0 |
| Using a soluble NAIL Fc fusion protein , we determined the counterstructure for NAIL , CD 48 , which it binds with high affinity . ^^^ Taken together these results indicate that the NAIL CD 48 interaction may be an important mechanism regulating a variety of immune responses . . ^^^ |
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| Interacting proteins: Q9BZW8 and P09326 |
Pubmed |
SVM Score :0.0 |
| NMR structure of the natural killer cell receptor 2B4 ( CD 244 ) : implications for ligand recognition . 2B4 , a transmembrane receptor expressed primarily on natural killer ( NK ) cells and on a subset of CD 8 ( + ) T cells , plays an important role in activating NK mediated cytotoxicity through its interaction with CD 48 on target cells . ^^^ |
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| Interacting proteins: Q9BZW8 and P09326 |
Pubmed |
SVM Score :0.0 |
| Human and mouse CD 150 share sequence homologies with six other genes , five of which CD 84 , CD 229 ( Ly 9 ) , CD 244 ( 2B4 ) , CD 48 , and 19A are localized in a 250 kb segment in close proximity to the human gene . ^^^ |
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| Interacting proteins: Q9BZW8 and P09326 |
Pubmed |
SVM Score :0.0 |
| The CD 2 subset of the immunoglobulin superfamily consists of a rapidly expanding family of leukocyte cell surface receptors , at least five of which ( CD 2 , CD 48 , CD 58 , CD 150 , and CD 244 ) are involved in lymphocyte activation as either receptors or ligands . ^^^ |
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| Interacting proteins: Q9BZW8 and P09326 |
Pubmed |
SVM Score :0.0 |
| The SLAM family of human genes currently consists of seven related members of the immunoglobulin superfamily , membrane associated proteins , including CD 150 ( SLAM ) , CD 244 ( 2B4 ) , CD 84 , CD 229 ( Ly 9 ) , BLAME , CD 48 , and 19A . ^^^ |
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| Interacting proteins: Q9BZW8 and P09326 |
Pubmed |
SVM Score :0.0 |
| CD 2 and 2B4 ( CD 244 ) are members of the immunoglobulin gene superfamily and are both ligands for another family member , CD 48 . ^^^ |
|
| Interacting proteins: Q9BZW8 and P09326 |
Pubmed |
SVM Score :0.0 |
| Natural killer ( NK ) cells are critical in the immune response to tumor cells , virally infected cells , and bone marrow allografts . 2B4 ( CD 244 ) is expressed on all NK cells and the ligand for 2B4 , CD 48 , is expressed on hematopoietic cells . ^^^ |
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| Interacting proteins: Q9BZW8 and P09326 |
Pubmed |
SVM Score :0.0 |
| NTBA Fc * specifically binds to NTBA cell transfectants but not to cells transfected with other CD 2 family members including CD 2 , CD 48 , CD 84 , CD 150 , CD 229 , and CD 244 . ^^^ |
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| Interacting proteins: Q9BZW8 and P09326 |
Pubmed |
SVM Score :0.0 |
| We show in this study that NK cells can enhance T cell activation and proliferation in response to CD 3 cross linking and specific Ag through interactions between 2B4 ( CD 244 ) on NK cells and CD 48 on T cells . ^^^ |
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| Interacting proteins: Q9BZW8 and P09326 |
Pubmed |
SVM Score :0.0 |
| Murine 2B4 ( CD 244 ) is a cell surface receptor expressed on all NK cells , gammadelta T cells , a subset of CD 8 ( + ) T cells , and all CD 14 ( + ) monocytes . 2B4 binds to CD 48 with high affinity , and cross linking 2B4 with anti 2B4 Ab in vitro causes activation of NK cells . ^^^ |
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| Interacting proteins: Q9BZW8 and P09326 |
Pubmed |
SVM Score :0.0 |
| NK cells from mice with targeted deletions of either the CD 2 or the CD 244 gene , both of which encode ligands for CD 48 , are compromised in their ability to induce B cell Igamma2a expression . ^^^ Interestingly , although CD 244 can bind to CD 48 with a higher affinity , the ability of NK cells from CD 244 ( / ) mice to stimulate Igamma2a is not as compromised as NK cells from CD 2 ( / ) mice . ^^^ |
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| Interacting proteins: Q9BZW8 and P09326 |
Pubmed |
SVM Score :0.0 |
| B4 ( CD 244 ) CD 48 interactions provide a novel MHC class 1 independent system for NK cell self tolerance in mice . ^^^ Here , we show that 2B4 ( CD 244 ) and CD 48 represent a second system for murine NK cell self recognition . 2B4 and MHC class 1 receptors act nonredundantly to inhibit NK lysis of syngeneic tumor cells . ^^^ |
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| Interacting proteins: Q9BZW8 and P09326 |
Pubmed |
SVM Score :0.0 |
| Cell surface receptors of the SLAM family , including CD 150 , CD 244 , and CD 48 , were differentially expressed among functionally distinct progenitors . ^^^ HSCs were highly purified as CD 150 ( + ) CD 244 ( ) CD 48 ( ) cells while MPPs were CD 244 ( + ) CD 150 ( ) CD 48 ( ) and most restricted progenitors were CD 48 ( + ) CD 244 ( + ) CD 150 ( ) . ^^^ |
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| Interacting proteins: Q9BZW8 and P09326 |
Pubmed |
SVM Score :0.0 |
| The induction of NK cell IL 13 mRNA expression requires the ligation of the CD 244 receptor by the CD 48 ligand on B cells via signaling pathways that depend upon expression of the 10 linked lymphoproliferative disease gene product , SH2D1A / DSHP / SAP ( SLAM associated protein , or SAP ) in NK cells . ^^^ |
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| Interacting proteins: Q9BZW8 and P09326 |
Pubmed |
SVM Score :0.0 |
| Adult HSC purity recently has been enhanced using the SLAM family receptors CD 150 , CD 244 , and CD 48 . ^^^ These markers are expressed at different stages of the hematopoiesis hierarchy , making it possible to highly purify adult HSCs as CD 150 ( + ) CD 48 ( ) CD 244 ( ) cells . ^^^ Fetal liver HSCs were CD 150 ( + ) CD 48 ( ) CD 244 ( ) , and the vast majority of colony forming progenitors were CD 48 ( + ) CD 244 ( ) CD 150 ( ) or CD 48 ( + ) CD 244 ( + ) CD 150 ( ) , just as in adult bone marrow . ^^^ Nonetheless , CD 150 , CD 244 , and CD 48 are not pan stem cell markers , as they were not detectably expressed by stem cells in the fetal or adult nervous system . . ^^^ |
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| Interacting proteins: Q9BZW8 and P09326 |
Pubmed |
SVM Score :0.0 |
| CD 48 stimulation by 2B4 ( CD 244 ) expressing targets activates human NK cells . ^^^ |
|
| Interacting proteins: Q9BZW8 and P09326 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BZW8 and P09326 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BZW8 and P09326 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BZW8 and P09326 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BZW8 and P09326 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BZW8 and P09326 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BZW8 and P09326 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BZW8 and P09326 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BZW8 and P09326 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BZW8 and P09326 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BZW8 and P09326 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BZW8 and P09326 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BZW8 and P09326 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BZW8 and P09326 |
Pubmed |
SVM Score :0.0 |
| NA |
|