| Interacting proteins: Q9BZW8 and O60880 |
Pubmed |
SVM Score :0.0 |
| The data suggest that signaling through SF 2000 , together with CD 150 , CD 244 , CD 84 , and CD 229 , is controlled by SAP and therefore contributes to the pathogenesis of XLP . . ^^^ Four of these family members ( CD 150 , CD 244 , CD 84 , CD 229 ) contain conserved tyrosine motifs in their cytoplasmic tails that enable them to bind intracellular signaling molecules SAP and EAT 2 . ^^^ |
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| Interacting proteins: Q9BZW8 and O60880 |
Pubmed |
SVM Score :0.0 |
| Surface lymphocyte activation marker ( SLAM ) associated protein ( SAP ) regulates lymphocyte activation via signals from cell surface CD 244 ( 2B4 ) and SLAM ( CD 150 ) . ^^^ At diagnosis , SAP , SLAM , and CD 244 were significantly up regulated on CD 4 and CD 8 T cells ; expression decreased during IM , but CD 244 and SLAM levels remained higher on CD 8 cells 40 days later . ^^^ We suggest that T cells expressing CD 244 and SLAM are responsible for the clinical features of IM but that the control of activation is maintained by parallel increased expression of SAP . . ^^^ |
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| Interacting proteins: Q9BZW8 and O60880 |
Pubmed |
SVM Score :0.0 |
| SAP is expressed in T cells , natural killer ( NK ) cells , and NKT cells , where it binds to the cytoplasmic domain of the surface receptor SLAM ( CD 150 ) and the related receptors , 2B4 ( CD 244 ) , CD 84 , Ly 9 ( CD 229 ) , NK T B antigen , and CD 2 like receptor activating cytotoxic T cells . ^^^ |
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| Interacting proteins: Q9BZW8 and O60880 |
Pubmed |
SVM Score :0.0 |
| NK cells from individuals with 10 linked lymphoproliferative ( XLP ) disease exhibit functional defects when stimulated through the NK receptor , 2B4 ( CD 244 ) . ^^^ |
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| Interacting proteins: Q9BZW8 and O60880 |
Pubmed |
SVM Score :0.0 |
| CD 244 interacts via its Src homology 2 domain with the 10 linked lymphoproliferative disease gene product signaling lymphocytic activation molecule associated protein ( SAP ) / SH2 domain protein 1A . 3BP2 interacts with human but not murine CD 244 . ^^^ Tyr 337 on CD 244 , part of a consensus motif for SAP / SH2 domain protein 1A binding , was critical for the 3BP2 interaction . ^^^ |
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| Interacting proteins: Q9BZW8 and O60880 |
Pubmed |
SVM Score :0.0 |
| The induction of NK cell IL 13 mRNA expression requires the ligation of the CD 244 receptor by the CD 48 ligand on B cells via signaling pathways that depend upon expression of the 10 linked lymphoproliferative disease gene product , SH2D1A / DSHP / SAP ( SLAM associated protein , or SAP ) in NK cells . ^^^ B cell induction of IL 13 expression in NK cells : role of CD 244 and SLAM associated protein . ^^^ |
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| Interacting proteins: Q9BZW8 and O60880 |
Pubmed |
SVM Score :0.0 |
| In addition to SLAM , SAP associates with several other cell surface receptors including 2B4 ( CD 244 ) , Ly 9 ( CD 229 ) , CD 84 and NTB A . ^^^ |
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| Interacting proteins: Q9BZW8 and O60880 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BZW8 and O60880 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BZW8 and O60880 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BZW8 and O60880 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BZW8 and O60880 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BZW8 and O60880 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BZW8 and O60880 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BZW8 and O60880 |
Pubmed |
SVM Score :0.0 |
| NA |
|