| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.75539747 |
| We show that MAG inhibits regeneration by interaction with NgR . 0.75539747^^^ |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :1.3054408 |
| Here , we show that MAG binds directly , with high affinity , to NgR . 1.3054408^^^ |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.51920281 |
| In previous studies we reported that MAG inhibits axonal regeneration by high affinity interaction ( K ( D ) 8 nM ) with the Nogo 66 receptor ( NgR ) and activation of a p 75 neurotrophin receptor ( p75NTR ) mediated signaling pathway . 0.51920281^^^ |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.0 |
| NgR is a common receptor for the three inhibitory myelin proteins Nogo A , OMgp , and MAG . ^^^ |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.0 |
| Recent findings indicate that three distinct myelin proteins , myelin associated glycoprotein ( MAG ) , Nogo , and oligodendrocyte myelin glycoprotein ( OMgp ) , inhibit axon growth by binding a common receptor , the Nogo 66 receptor ( NgR ) , and likely converge on a common signaling cascade . . ^^^ |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.0 |
| In inhibiting neurite outgrowth , several myelin components , including the extracellular domain of Nogo A ( Nogo 66 ) , oligodendrocyte myelin glycoprotein ( OMgp ) and myelin associated glycoprotein ( MAG ) , exert their effects through the same Nogo receptor ( NgR ) . ^^^ |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.0 |
| Myelin associated glycoprotein ( MAG ) , an inhibitor of axon regeneration , binds with high affinity to the Nogo 66 receptor ( NgR ) . ^^^ Here we report that the p 75 neurotrophin receptor ( p 75 ( NTR ) ) is a co receptor of NgR for MAG signaling . ^^^ In cultured human embryonic kidney ( HEK ) cells expressing NgR , p 75 ( NTR ) was required for MAG induced intracellular Ca2+ elevation . ^^^ Furthermore , NGFR 5 abolished MAG induced repulsive turning of Xenopus axonal growth cones and Ca2+ elevation , both in neurons and in NgR / p75 ( NTR ) expressing HEK cells . ^^^ Thus we conclude that p 75 ( NTR ) is a co receptor of NgR for MAG signaling and a potential therapeutic target for promoting nerve regeneration . . ^^^ |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we show that the recently cloned receptor for Nogo 66 and MAG , NgR , is not necessary for either NiG or MAG induced RhoA activation . . ^^^ |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.0 |
| The three axon growth inhibitory proteins , myelin associated glycoprotein , oligodendrocyte myelin glycoprotein and Nogo A , can all bind to the Nogo 66 receptor ( NgR ) . ^^^ |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.0 |
| Nogo 66 receptor ( NgR ) has recently been identified as the neuronal receptor of the myelin associated proteins Nogo A , oligodendrocyte protein ( OMgp ) and myelin associated glycoprotein ( MAG ) , and mediates inhibition of axonal regeneration both in vitro and in vivo . ^^^ |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.0 |
| The myelin derived axon outgrowth inhibitors Nogo , oligodendrocyte myelin glycoprotein , and myelin associated glycoprotein , all bind to an axonal Nogo 66 receptor ( NgR ) and at least partially account for this lack of CNS repair . ^^^ |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.0 |
| Although Nogo , MAG and OMgp lack sequence homologies , they all bind to the Nogo receptor ( NgR ) , a GPI linked cell surface molecule which , in turn , binds p 75 to activate RhoA . ^^^ |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.0 |
| By deletion analysis , we show that the binding of soluble fragments of Nogo , MAG and NgR to cell surface NgR requires the entire leucine rich repeat ( LRR ) region of NgR , but not other portions of the protein . ^^^ Despite sharing extensive sequence similarity with NgR , two related proteins , NgR 2 and NgR 3 , which we have identified , do not bind Nogo , MAG , OMgp or NgR . ^^^ |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.0 |
| NgR binds to several myelin associated ligands ( Nogo 66 , myelin associated glycoprotein , and oligodendrocyte myelin glycoprotein ) , which , among other inhibitory proteins , impair axonal regeneration in the CNS of adult mammals . ^^^ |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.0 |
| NgR mediates the growth inhibiting effects of three myelin proteins , Nogo , OMgp ( oligodendrocyte myelin glycoprotein ) , and MAG ( myelin associated glycoprotein ) . ^^^ |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.0 |
| Recent findings indicate that Nogo A , oligodendrocyte myelin glycoprotein ( OMgp ) , and myelin associated glycoprotein ( MAG ) inhibit axonal growth by binding a common receptor , the Nogo A receptor ( NgR ) p 75 complex . ^^^ |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.0 |
| The Lingo 1 NgR p75NTR complex is shown to confer the inhibitory effects on nerve cell regeneration of Nogo 66 , OMgP , and MAG by activating the small guanosine triphosphatase ( GTPase ) RhoA . ^^^ |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.0 |
| U87MG cells contained significant amounts of endogenous Nogo 66 receptor ( NgR ) , and treatment of the cells with phosphatidylinositol specific phospholipase C ( PI PLC ) or NgR antibodies resulted in an increase in their ability to adhere to , or migrate through , Nogo 66 and MAG coated substrates . ^^^ Nogo 66 and MAG may therefore modulate glioma growth and migration by acting through the NgR , a phenomenon that has potential therapeutic implications . . ^^^ |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.0 |
| The central nervous system myelin components oligodendrocyte myelin glycoprotein , myelin associated glycoprotein and the Nogo 66 domain of Nogo A inhibit neurite outgrowth by binding the neuronal glycosyl phosphatidylinositol anchored Nogo 66 receptor ( NgR ) that transduces the inhibitory signal to the cell interior via a transmembrane co receptor , p75NTR . ^^^ |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.0 |
| MAG , OMgp as well as the Nogo specific domain Nogo 66 exert their inhibitory activity by binding to a neuronal receptor complex containing the Nogo 66 receptor NgR and the neurotrophin receptor p 75 ( NTR ) . ^^^ |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.0 |
| Three myelin proteins , Nogo , MAG ( myelin associated glycoprotein ) , and OMgp ( oligodendrocyte myelin glycoprotein ) , bind to the Nogo 66 receptor ( NgR ) and inhibit axonal growth in vitro . ^^^ |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.0 |
| These data indicate that the NgR ligands , Nogo 66 , MAG , and OMgp , play a role in limiting axonal growth in the injured adult CNS and that NgR ( 310 ) ecto might provide a therapeutic means to promote recovery from SCI . . ^^^ |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.0 |
| The p 75 neurotrophin receptor ( p75NTR ) collaborates with the Nogo receptor ( NgR ) and LINGO 1 to activate RhoA in response to myelin based growth inhibitors such as myelin associated glycoprotein ( MAG ) . ^^^ |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.0 |
| The inhibitory proteins Nogo , myelin associated glycoprotein ( MAG ) and oligodendrocyte myelin glycoprotein ( OMgp ) all bind to the extracellular leucine rich repeat ( LRR ) domain of NgR , which provides a large molecular surface for protein protein interactions . ^^^ However , epitopes within the LRR domain of NgR for binding Nogo , MAG and OMgp have not yet been revealed . ^^^ |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.0 |
| Thus , physiological NgR signaling from myelin derived Nogo , MAG , and OMgp consolidates the neural circuitry established during experience dependent plasticity . ^^^ |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.0 |
| The regeneration potential of the adult mammalian central nervous system ( CNS ) is very modest , due to , among other factors , the presence of either a glial scar , or myelin associated regeneration inhibitors such as Nogo A , MAG and OMgp , which all interact with the same receptor ( NgR ) . ^^^ |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.0 |
| Therefore , we have examined the levels of mRNA encoding Nogo , OMgp and MAG , as well as the receptor components NgR , Lingo 1 and Troy in cortex and hippocampus of young ( 4 months ) , middle aged ( 16 months ) and old ( 24 months ) Fisher 344 rats . ^^^ |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.0 |
| Sera of vaccinated animals were tested for antibodies against myelin associated glycoprotein , NogoA , Nogo 66 receptor , or chondroitin sulphate proteoglycans ( CSPG ) , but no significant levels were detected . ^^^ |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.0 |
| Furthermore , a recombinant form of MAG interacts specifically with lipid raft fractions from whole brain and cultured cerebellar granule cells , containing functional MAG receptors GT1b and Nogo 66 receptor and molecules required for transduction of signal from MAG into neurons . ^^^ |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.0 |
| The Nogo 66 receptor ( NgR 1 ) is a neuronal , leucine rich repeat ( LRR ) protein that binds three central nervous system ( CNS ) myelin proteins , Nogo , myelin associated glycoprotein , and oligodendrocyte myelin glycoprotein , and mediates their inhibitory effects on neurite growth . ^^^ |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.0 |
| The Nogo 66 receptor ( NgR 1 ) is a promiscuous receptor for the myelin inhibitory proteins Nogo / Nogo 66 , myelin associated glycoprotein ( MAG ) , and oligodendrocyte myelin glycoprotein ( OMgp ) . ^^^ The Nogo 66 receptor homolog NgR 2 is a sialic acid dependent receptor selective for myelin associated glycoprotein . ^^^ |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.0 |
| The neurotrophin receptor p75NTR is the coreceptor for Nogo receptor , mediating growth cone collapse in vitro by MAG , myelin oligodendrocyte glycoprotein ( Omgp ) , and Nogo . ^^^ |
|
| Interacting proteins: Q9BZR6 and P20916 |
Pubmed |
SVM Score :0.0 |
| Here we show that gangliosides , GT1b and GD1a , as well as the Nogo receptor , are functional binding partners for soluble MAG Fc . ^^^ |
|