| Interacting proteins: Q9BXN2 and O60603 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BXN2 and O60603 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BXN2 and O60603 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BXN2 and O60603 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BXN2 and O60603 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BXN2 and O60603 |
Pubmed |
SVM Score :0.74121996 |
| Here , we demonstrate that the beta glucan receptor Dectin 1 , a yeast binding C type lectin known to synergize with TLR 2 to induce TNF alpha and IL 12 , can also promote synthesis of IL 2 and IL 10 through phosphorylation of the membrane proximal tyrosine in the cytoplasmic domain and recruitment of Syk kinase . syk / dendritic cells ( DCs ) do not make IL 10 or IL 2 upon yeast stimulation but produce IL 12 , indicating that the Dectin 1 / Syk and Dectin 1 / TLR2 pathways can operate independently . 0.74121996^^^ |
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| Interacting proteins: Q9BXN2 and O60603 |
Pubmed |
SVM Score :0.0 |
| Collaborative induction of inflammatory responses by dectin 1 and Toll like receptor 2 . ^^^ |
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| Interacting proteins: Q9BXN2 and O60603 |
Pubmed |
SVM Score :0.0 |
| Taken together , these results show that cytokine responses in mouse peritoneal macrophages to C . posadasii spherules are dependent on TLR 2 , MyD 88 , and Dectin 1 . . ^^^ Innate immunity to the pathogenic fungus Coccidioides posadasii is dependent on Toll like receptor 2 and Dectin 1 . ^^^ |
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| Interacting proteins: Q9BXN2 and O60603 |
Pubmed |
SVM Score :0.0 |
| We have investigated the mechanisms of inflammation in murine zymosan induced arthritis ( ZIA ) in the light of recent data on the roles of Toll like receptor 2 ( TLR 2 ) and Dectin 1 in the activation of monocyte / macrophages by zymosan . ^^^ The severity of inflammation , joint histology , lymphocyte proliferation and antibody production in response to zymosan were analyzed in mice deficient in TLR 2 and complement C 3 , and the effects of Dectin 1 inhibition by laminarin were studied . ^^^ |
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| Interacting proteins: Q9BXN2 and O60603 |
Pubmed |
SVM Score :0.0 |
| Furthermore , dectin 1 receptors rather than Toll like receptor 2 receptors were shown to be necessary for both efficient internalization of beta glucan particles and cytokine release in response to the fungal cell wall component . . ^^^ |
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| Interacting proteins: Q9BXN2 and O60603 |
Pubmed |
SVM Score :0.0 |
| The results suggest that cytosolic phospholipase A ( 2 ) activation triggered by the beta glucan component of yeast is dependent on the immunoreceptor tyrosine based activation motif like domain of dectin 1 and activation of Syk kinase , whereas both TLR 2 and Syk kinase regulate COX 2 expression . . ^^^ |
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| Interacting proteins: Q9BXN2 and O60603 |
Pubmed |
SVM Score :0.0 |
| Dectin 1 binding to germ tubes augments , but is not required for , TLR 2 mediated inflammatory cytokine secretion . ^^^ Dectin 1 recognition of germ tubes also stimulates TNF alpha production in the absence of both TLR 2 and MyD 88 signaling . ^^^ |
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| Interacting proteins: Q9BXN2 and O60603 |
Pubmed |
SVM Score :0.0 |
| Yeast zymosan , a stimulus for TLR 2 and dectin 1 , induces regulatory antigen presenting cells and immunological tolerance . ^^^ Here , we show that zymosan , a stimulus for TLR 2 and dectin 1 , regulates cytokine secretion in DCs and macrophages to induce immunological tolerance . ^^^ Induction of IL 10 is dependent on TLR 2 and dectin 1 mediated activation of ERK MAPK via a mechanism independent of the activation protein 1 ( AP 1 ) transcription factor c Fos . ^^^ |
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| Interacting proteins: Q9BXN2 and O60603 |
Pubmed |
SVM Score :0.0 |
| Dectin 1 increased TLR 2 mediated NF kappaB activation in response to zymosan . ^^^ However , dectin 1 alone could not affect the activation pathway for NF kappaB , nor did co expression of dectin 1 mutant and TLR 2 increase the NF kappaB activation . ^^^ |
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