| Interacting proteins: Q9BQ95 and Q13233 |
Pubmed |
SVM Score :0.0 |
| This adapter protein , which we have named ECSIT ( evolutionarily conserved signaling intermediate in Toll pathways ) , is specific for the Toll / IL 1 pathways and is a regulator of MEKK 1 processing . ^^^ Expression of wild type ECSIT accelerates processing of MEKK 1 , whereas a dominant negative fragment of ECSIT blocks MEKK 1 processing and activation of NF kappaB . ^^^ These results indicate an important role for ECSIT in signaling to NF kappaB and suggest that processing of MEKK 1 is required for its function in the Toll / IL 1 pathway . . ^^^ |
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| Interacting proteins: Q9BQ95 and Q13233 |
Pubmed |
SVM Score :0.0 |
| Cotransfection of the COX 2 reporter with dominant negative expression vectors shows that endotoxin induced COX 2 gene expression requires signaling through a Ras independent pathway involving the adapter protein ECSIT and the signaling kinases MEKK 1 and JNK . ^^^ |
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