| Interacting proteins: P51787 and Q99996 |
Pubmed |
SVM Score :0.0 |
| Further biochemical studies ruled out three candidate proteins , namely KCNE 1 , yotiao , and KCNQ 1 itself , as effectors of this coiled coil mediated trafficking . ^^^ |
|
| Interacting proteins: P51787 and Q99996 |
Pubmed |
SVM Score :0.0 |
| A kinase anchoring proteins ( AKAPs ) are thought to be passive members of protein complexes that coordinate the association of cAMP dependent protein kinase A ( PKA ) with cellular substrates to facilitate targeted PKA protein phosphorylation . 1 ( Ks ) , the slow heart potassium current , is carried by the 1 ( Ks ) potassium channel , a substrate for PKA phosphorylation in response to sympathetic nerve stimulation , is a macromolecular complex that includes the KCNQ 1 alpha subunit , the KCNE 1 regulatory subunit , and the AKAP Yotiao . ^^^ |
|
| Interacting proteins: P51787 and Q99996 |
Pubmed |
SVM Score :0.0 |
| We reconstituted 1 ( Ks ) in CHO cells ( ie , KCNQ 1 coexpressed with KCNE 1 and the adaptator protein Yotiao ) and quantitatively examined the effects of beta adrenergic stimulation on channel kinetics . ^^^ |
|
| Interacting proteins: P51787 and Q99996 |
Pubmed |
SVM Score :0.0 |
| The replacement of Ser 43 by Ala ablates the PKA phosphorylation of N T Yotiao and markedly diminishes the functional response of the wild type and pseudo phosphorylated 1 ( Ks ) channel to cAMP but neither prevents the PKA phosphorylation of KCNQ 1 nor its binding to Yotiao . ^^^ |
|