| Interacting proteins: O95613 and Q99996 |
Pubmed |
SVM Score :0.0 |
| Characterization of a Drosophila centrosome protein CP 309 that shares homology with Kendrin and CG NAP . ^^^ |
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| Interacting proteins: O95613 and Q99996 |
Pubmed |
SVM Score :0.0 |
| The amplified centrosomes co localized with centrosome markers gamma tubulin , centrin 2 and kendrin as well as endogenous CG NAP . ^^^ |
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| Interacting proteins: O95613 and Q99996 |
Pubmed |
SVM Score :0.0 |
| Despite its association with gamma TuRC anchoring proteins CG NAP and Kendrin , Cep 55 is not required for microtubule nucleation . ^^^ |
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| Interacting proteins: O95613 and Q99996 |
Pubmed |
SVM Score :0.0 |
| Numerous coiled coil structures were predicted from AKAP 450 , and weak homology to pericentrin , giantin and other structural proteins was observed . ^^^ |
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| Interacting proteins: O95613 and Q99996 |
Pubmed |
SVM Score :0.0 |
| AKAP 450 ( also known as AKAP 350 , CG NAP or Hyperion ) and pericentrin are large coiled coil proteins found in mammalian centrosomes that serve to recruit structural and regulatory components including dynein and protein kinase A . ^^^ The PACT domain , a conserved centrosomal targeting motif in the coiled coil proteins AKAP 450 and pericentrin . ^^^ AKAP 450 ( also known as AKAP 350 , CG NAP or Hyperion ) and pericentrin are large coiled coil proteins found in mammalian centrosomes that serve to recruit structural and regulatory components including dynein and protein kinase A . ^^^ Fusion of the C terminal region from either protein to a reporter protein confers a centrosomal localization , and overexpression of the domain from AKAP 450 displaces endogenous pericentrin , suggesting recruitment to a shared site . ^^^ |
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| Interacting proteins: O95613 and Q99996 |
Pubmed |
SVM Score :0.0 |
| We report that the expression in HeLa cells of the C terminus of AKAP 450 , which contains the centrosome targeting domain of AKAP 450 but not its coiled coil domains or binding sites for signaling molecules , leads to the displacement of the endogenous centrosomal AKAP 450 without removing centriolar or pericentrosomal components such as centrin , gamma tubulin , or pericentrin . ^^^ |
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| Interacting proteins: O95613 and Q99996 |
Pubmed |
SVM Score :0.0 |
| We also demonstrate that centrosomal proteins such as centrin and pericentrin , but not gamma tubulin , AKAP 450 , or ninein , undertake a nucleocytoplasmic exchange as they concentrate in the nucleus upon export inhibition by leptomycin B . ^^^ |
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| Interacting proteins: O95613 and Q99996 |
Pubmed |
SVM Score :0.0 |
| Centrosomal proteins CG NAP and kendrin provide microtubule nucleation sites by anchoring gamma tubulin ring complex . ^^^ The amino terminal region of either CG NAP or kendrin indirectly associated with gamma tubulin through binding with gamma tubulin complex protein 2 ( GCP 2 ) and / or GCP 3 . ^^^ Furthermore , endogenous CG NAP and kendrin were coimmunoprecipitated with each other and with endogenous GCP 2 and gamma tubulin , suggesting that CG NAP and kendrin form complexes and interact with gamma TuRC in vivo . ^^^ Pretreatment of the centrosomes by antibody to CG NAP or kendrin moderately inhibited the microtubule nucleation ; moreover , the combination of these antibodies resulted in stronger inhibition . ^^^ These results imply that CG NAP and kendrin provide sites for microtubule nucleation in the mammalian centrosome by anchoring gamma TuRC . . ^^^ |
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