| Interacting proteins: Q99985 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99985 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99985 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99985 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99985 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99985 and O14786 |
Pubmed |
SVM Score :0.0 |
| Unlike neuropilin 1 , which binds with high affinity to the three structurally related semaphorins Sema 3 , Sema E , and Sema 4 , neuropilin 2 shows high affinity binding only to Sema E and Sema 4 , not Sema 3 . ^^^ |
|
| Interacting proteins: Q99985 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 and neuropilin 2 show specificity in binding to different class 3 semaphorins , including Sema 3 , Sema E , and Sema 4 , suggesting that the specificity of action of these semaphorins is dictated by the complement of neuropilins expressed by responsive neurons . ^^^ In support of this , we show that sympathetic axons coexpress neuropilin 1 and 2 , that their responses to Sema 3 , Sema E , and Sema 4 are affected in predicted ways by antibodies to neuropilin 1 , and that neuropilin 1 and 2 can form homo and heterooligomers through an interaction involving at least partly the neuropilin MAM ( meprin , A 5 , mu ) domain . ^^^ These results support the idea that in sympathetic axons , the Sema 3 signal is mediated predominantly by neuropilin 1 oligomers , the Sema 4 signal by neuropilin 2 oligomers , and the Sema E signal by neuropilin 1 and 2 , either as homo or heterooligomers . . ^^^ |
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| Interacting proteins: Q99985 and O14786 |
Pubmed |
SVM Score :0.0 |
| Also enriched were genes in semaphorin / neuropilin ( Sema3c and Nrp 1 ) , ephrin / Eph ( ephrin A 1 , B 1 , B 2 , and EphB 4 ) , delta / notch ( Hey 1 , Jagged 2 , Notch 1 , Notch 4 , Numb , and Siah1b ) , and Wingless ( Frizzled 4 and Tle 1 ) signaling pathways involved in vascular development and angiogenesis . ^^^ |
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| Interacting proteins: Q99985 and O14786 |
Pubmed |
SVM Score :0.0 |
| Moreover sema3C induced neuritogenesis of cultured CGNs , which express neuropilin 1 and 2 . ^^^ |
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| Interacting proteins: Q99985 and O14786 |
Pubmed |
SVM Score :0.0 |
| Following up on that initial observation , we have now used real time quantitative reverse transcription polymerase chain reaction to demonstrate induction of genes encoding neuropilin 1 ( NP 1 ) , which , like NP 2 , serves as a coreceptor for members of the class 3 semaphorin family of axonal guidance molecules and of five of the six known class 3 semaphorins ( Sema3A , Sema3B , Sema3C , Sema3E , and Sema3F , but not Sema3D ) in crushed or transected sciatic nerves . . ^^^ |
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