| Interacting proteins: Q99933 and P50502 |
Pubmed |
SVM Score :0.0 |
| Thus , BAG 1 regulates the Hsc 70 ATPase in a manner contrary to the Hsc 70 interacting protein Hip , which stabilizes the ADP bound state . ^^^ Intriguingly , BAG 1 and Hip compete in binding to the ATPase domain of Hsc 70 . ^^^ |
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| Interacting proteins: Q99933 and P50502 |
Pubmed |
SVM Score :0.0 |
| The modulation of the chaperone activity of the heat shock cognate Hsc 70 protein in mammalian cells involves cooperation with chaperone cofactors , such as Hsp 40 ; BAG 1 ; the Hsc 70 interacting protein , Hip ; and the Hsc 70 Hsp90 organizing protein , Hop . ^^^ On the other hand , BAG 1 and Hip have recently been shown to compete in binding to the ATPase domain . ^^^ |
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| Interacting proteins: Q99933 and P50502 |
Pubmed |
SVM Score :0.0 |
| BAG 1 acts as a nucleotide exchange factor in the Hsc 70 ATPase cycle , thereby competing with the cofactor Hip which stabilizes the ADP bound state of Hsc 70 . ^^^ |
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| Interacting proteins: Q99933 and P50502 |
Pubmed |
SVM Score :0.0 |
| In contrast , the cofactor BAG 1 abrogates the ' holding ' function of the Hsc70 / Hsp40 system and blocks the action of Hip on Hsc 70 . ^^^ |
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| Interacting proteins: Q99933 and P50502 |
Pubmed |
SVM Score :0.0 |
| BAG 1 binds the ATPase domains of Hsp 70 and Hsc 70 , modulating their chaperone activity and functioning as a competitive antagonist of the co chaperone Hip . ^^^ The human BAG 1 , BAG 2 , and BAG 3 proteins bind with high affinity ( KD congruent with 1 10 nM ) to the ATPase domain of Hsc 70 and inhibit its chaperone activity in a Hip repressible manner . ^^^ |
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| Interacting proteins: Q99933 and P50502 |
Pubmed |
SVM Score :0.0 |
| The chaperone function of the mammalian 70 kDa heat shock proteins Hsc 70 and Hsp 70 is modulated by physical interactions with four previously identified chaperone cofactors : Hsp 40 , BAG 1 , the Hsc 70 interacting protein Hip , and the Hsc 70 Hsp90 organizing protein Hop . ^^^ |
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| Interacting proteins: Q99933 and P50502 |
Pubmed |
SVM Score :0.0 |
| At low BAG 1 : hsp70 / hsc70 ratios , BAG 1 promoted the release of Hop from the hsp 90 based chaperone system without inhibiting GR . hsp90 heterocomplex assembly . ^^^ These observations suggest that , at physiological concentrations , BAG 1 modulates assembly by promoting Hop release from the assembly complex ; but , at concentrations closer to those in transfected cells and some transformed cell lines , hsp 70 is continuously bound by BAG 1 , and heterocomplex assembly is blocked . . ^^^ |
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| Interacting proteins: Q99933 and P50502 |
Pubmed |
SVM Score :0.0 |
| Additional protein cofactors include Hip and Bag 1 , identified in protein interaction assays , which bind to and modulate Hsp 70 chaperone activity in vitro . ^^^ |
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| Interacting proteins: Q99933 and P50502 |
Pubmed |
SVM Score :0.0 |
| Hip does not affect glucocorticoid receptor folding by the hsp 90 based chaperone machinery except to oppose the effect of BAG 1 . ^^^ In the five protein system , Hip prevents inhibition of assembly by the hsp 70 co chaperone BAG 1 , and cotransfection of Hip with BAG 1 opposes BAG 1 reduction of steroid binding activity in COS cells . ^^^ We conclude that Hip is not a component of the assembly machinery but that it could play a regulatory role in opposition to BAG 1 . . ^^^ |
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| Interacting proteins: Q99933 and P50502 |
Pubmed |
SVM Score :0.0 |
| Results from coimmunoprecipitation and colocalization studies indicate that this molecular chaperone forms complexes with other molecular chaperones and cochaperones , including Hsp 90 , Hsp 40 , the Hsp 70 Hsp90 organizing protein ( Hop ) , the Hsp 70 interacting protein ( Hip ) , and the Bcl 2 associated athanogene 1 protein ( BAG 1 ) . ^^^ |
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| Interacting proteins: Q99933 and P50502 |
Pubmed |
SVM Score :0.0 |
| Co chaperones Bag 1 , Hop and Hsp 40 regulate Hsc 70 and Hsp 90 interactions with wild type or mutant p 53 . ^^^ The anti apoptotic factor Bag 1 can dissociate Hsp 90 from a pre assembled complex wild type p 53 protein , but it can not dissociate a pre assembled p53R175H Hsp 40 Hsc 70 Hop Hsp 90 heterocomplex . ^^^ |
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| Interacting proteins: Q99933 and P50502 |
Pubmed |
SVM Score :0.0 |
| During proteasomal sorting BAG 1 can cooperate with another co chaperone , the carboxyl terminus of Hsc 70 interacting protein CHIP . ^^^ |
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| Interacting proteins: Q99933 and P50502 |
Pubmed |
SVM Score :0.0 |
| The functional role of Hsc 70 in L topogenesis was confirmed through modulation of its in vivo activity by overexpressing its co chaperones Hip and Bag 1 . ^^^ Overexpression of the Hsc 70 stimulating molecule Hip led to increased entrapping of preS on the cytosolic ER face and hence to a decrease in preS posttranslocation , whereas the negative regulator Bag 1 had the opposite effects . ^^^ |
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| Interacting proteins: Q99933 and P50502 |
Pubmed |
SVM Score :0.0 |
| A recent genome survey indicates that Archaea do not harbor well conserved equivalents of the co chaperones trigger factor , Hip , Hop , BAG 1 , and NAC , although the data suggest that Archaea have proteins related to Hop and to the NAC alpha subunit whose functions remain to be elucidated . ^^^ |
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| Interacting proteins: Q99933 and P50502 |
Pubmed |
SVM Score :0.0 |
| To induce apoptosis , GC bind to the GC receptor ( GR ) , which is regulated by various ( co ) chaperone proteins such as heat shock protein 70 ( HSP 70 ) , HSP 40 , HIP ( HSP 70 interacting protein ) , BAG 1 ( BCL 2 associated gene product 1 ) , HOP ( HSP 70 / HSP 90 Organizing protein ) , HSP 90 , P 23 , FKBP 51 , FKBP 52 and CYP 40 . ^^^ |
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