| Interacting proteins: Q99933 and P10275 |
Pubmed |
SVM Score :0.0 |
| The recently identified BAG 1 long ( BAG 1L ) protein , an isoform of BAG 1 that arises from translation initiation at a noncanonical CUG codon , was co immunoprecipitated with androgen receptors ( AR ) from LNCaP prostate cancer cells and other cell lysates , whereas the shorter originally identified BAG 1 and BAG 1M ( RAP 46 ) proteins were not . ^^^ BAG 1L , but not BAG 1 or BAG 1M ( RAP 46 ) , also markedly enhanced the ability of AR to transactivate reporter gene plasmids containing an androgen response element ( ARE ) in PC 3 prostate cancer and other cell lines . ^^^ |
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| Interacting proteins: Q99933 and P10275 |
Pubmed |
SVM Score :0.0 |
| The human BAG 1 , BAG 2 , and BAG 3 proteins bind with high affinity ( KD congruent with 1 10 nM ) to the ATPase domain of Hsc 70 and inhibit its chaperone activity in a Hip repressible manner . ^^^ |
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| Interacting proteins: Q99933 and P10275 |
Pubmed |
SVM Score :0.0 |
| Given its proposed involvement in multiple cell signaling events as a regulator of Raf 1 , Bcl 2 , or androgen receptor , we wondered whether Bag 1 functions in vivo as a negative regulator of Hsp 70 . ^^^ |
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| Interacting proteins: Q99933 and P10275 |
Pubmed |
SVM Score :0.0 |
| Although Bag1L , Bag1M , and Bag 1 can bind the androgen receptor ( AR ) in vitro , only Bag1L enhanced AR transcriptional activity . ^^^ Forced nuclear targeting of Bag1M , but not Bag 1 or Bag1S , resulted in potent AR coactivation , indicating that Bag1M possesses the necessary structural features provided it is expressed within the nucleus . ^^^ |
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| Interacting proteins: Q99933 and P10275 |
Pubmed |
SVM Score :0.0 |
| Direct interaction with 70 kD heat shock proteins , HSC 70 and HSP 70 , may mediate the diverse functions of BAG 1 . ^^^ |
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| Interacting proteins: Q99933 and P10275 |
Pubmed |
SVM Score :0.0 |
| BAG 1 expression in hyperplastic and neoplastic prostate tissue : is there any relationship with BCL related proteins and androgen receptor status . ^^^ AIMS AND BACKGROUND : To evaluate the function and distribution of BAG 1 protein in hyperplastic and neoplastic prostate tissue and establish the relationship between this protein and BCL related proteins ( BCL 2 and BAX ) , androgen receptor ( AR ) expression and chromogranin A . ^^^ BAG 1 , BCL 2 , BAX , androgen receptor and chromogranin A immunostaining was performed by means of standard avidin biotin peroxidase methods . ^^^ We also detected a positive correlation between AR and nuclear / cytoplasmic BAG 1 and between nuclear and cytoplasmic BAG 1 in hyperplasias . ^^^ |
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| Interacting proteins: Q99933 and P10275 |
Pubmed |
SVM Score :0.0 |
| BAG 1 is a co chaperone that regulates the activity of Hsp 70 , Bcl 2 , Raf 1 , growth factor , and steroid receptors ( e . g . , the Androgen Receptor ) . ^^^ |
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| Interacting proteins: Q99933 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q99933 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99933 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
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