| Interacting proteins: Q99933 and P03372 |
Pubmed |
SVM Score :0.0 |
| BAG 1 / HAP is a multifunctional protein which complexes with BCL 2 and steroid hormone receptors ( including the ER ) , and can suppress apoptosis and influence steroid hormone dependent transcription . ^^^ BAG 1 was readily detected by immunostaining in normal breast epithelial cells and most ER positive tumours , but was undetectable or weakly expressed in ER negative tumours . ^^^ A correlation between ER and BAG 1 was also evident in breast cancer derived cell lines , as all lines examined with functional ER expression also expressed high levels of BAG 1 . ^^^ These results demonstrate a close association between BAG 1 and functional ER expression and suggest BAG 1 may be useful as a therapeutic target or prognostic marker in breast cancer . . ^^^ |
|
| Interacting proteins: Q99933 and P03372 |
Pubmed |
SVM Score :0.0 |
| PATIENTS AND METHODS : Archival paraffin blocks from 122 women with stages 1 to 2 breast cancer treated with lumpectomy and radiation therapy ( median follow up , 12 . 1 years ) were analyzed by immunohistochemical methods using monoclonal antibodies recognizing BAG 1 and other biomarkers , including Bcl 2 , estrogen receptor , progesterone receptor , p 53 , and HER2 / Neu . ^^^ |
|
| Interacting proteins: Q99933 and P03372 |
Pubmed |
SVM Score :0.0 |
| The clonogenic growth of breast cancer cell lines was inhibited by a ligand for PPARgamma ( troglitazone , TGZ ) combined with a ligand for either retinoid 10 receptor ( RXR ) ( LG 10069 ) ( 4 / 8 cell lines ) , RAR ( ATRA ) ( 5 / 8 cell lines ) or RAR / RXR and RXR / RXR ( 9 cis RA ) ( 5 / 8 cell lines ) independent of their expression of bcl 2 , bag 1 , ERalpha , and p 53 . ^^^ Importantly , this effect was independent of expression levels of p 53 , ERalpha , HER 2 / neu , bag 1 , and BRCA 1 . ^^^ |
|
| Interacting proteins: Q99933 and P03372 |
Pubmed |
SVM Score :0.0 |
| Overexpression of the Hsc 70 stimulating molecule Hip led to increased entrapping of preS on the cytosolic ER face and hence to a decrease in preS posttranslocation , whereas the negative regulator Bag 1 had the opposite effects . ^^^ |
|
| Interacting proteins: Q99933 and P03372 |
Pubmed |
SVM Score :0.0 |
| Here we have investigated the effects of BAG 1 on function of the oestrogen receptor ( ER ) , a key growth control molecule and target for hormonal therapy in breast cancer . ^^^ Consistent with an important effect on receptor function , nuclear BAG 1 expression in breast cancers was associated with expression of the progesterone receptor , a transcriptional target of ERalpha , and was associated with improved survival in patients treated with hormonal therapy . ^^^ |
|
| Interacting proteins: Q99933 and P03372 |
Pubmed |
SVM Score :0.0 |
| There was no relationship between positive nuclear BAG 1 expression and either estrogen receptor ( ER ) or progesterone receptor ( PR ) expression . ^^^ |
|
| Interacting proteins: Q99933 and P03372 |
Pubmed |
SVM Score :0.0 |
| Estrogen receptor beta ( ERbeta ) protein expression correlates with BAG 1 and prognosis in brain glial tumours . ^^^ |
|
| Interacting proteins: Q99933 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|