| Interacting proteins: Q99767 and P05067 |
Pubmed |
SVM Score :0.0 |
| Here we report the cloning of full length mouse Mint 2 and demonstrate that in primary cortical neurons , Mint 2 and APP share highly similar distributions . ^^^ Mint 2 also colocalizes with APP in transfected CHO cells . ^^^ In Mint2 / APP cotransfected cells , Mint 2 reorganizes the subcellular distribution of APP and also increases the steady state levels of APP . ^^^ These results are consistent with a role for Mint 2 in APP metabolism and trafficking , and suggest a possible role for the Mints / X11s in the pathogenesis of Alzheimer ' s disease . . ^^^ |
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| Interacting proteins: Q99767 and P05067 |
Pubmed |
SVM Score :0.0 |
| The kappaB motif dependent production of Abeta 42 was suppressed by binding of NF kappaB / p65 to the PDZ domain of the X 11 like protein ( X11L ) , which a human homologue protein of LIN 10 . ^^^ |
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| Interacting proteins: Q99767 and P05067 |
Pubmed |
SVM Score :0.0 |
| X 11 like ( X11L , also referred to as X11beta and Mint 2 ) , which is a member of the mammalian LIN 10 protein family and a possible regulator of Abeta production , elevated APP and APLP 2 phosphorylation probably by facilitating JNK mediated phosphorylation , whereas other members of the family , X 11 and X11L2 , did not . ^^^ |
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| Interacting proteins: Q99767 and P05067 |
Pubmed |
SVM Score :0.0 |
| APP adaptor proteins with phosphotyrosine binding domains , including X11alpha ( MINT 1 , encoded by gene APBA 1 ) and X11beta ( MINT 2 , encoded by gene APBA 2 ) , can bind to the conserved YENPTY motif in the APP C terminus . ^^^ RNAi silencing of APBA 2 also lowered Abeta levels , but apparently not via attenuation of gamma secretase cleavage of APP . ^^^ |
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| Interacting proteins: Q99767 and P05067 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99767 and P05067 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99767 and P05067 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99767 and P05067 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99767 and P05067 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99767 and P05067 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99767 and P05067 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99767 and P05067 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99767 and P05067 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99767 and P05067 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99767 and P05067 |
Pubmed |
SVM Score :0.0 |
| NA |
|