| Interacting proteins: Q13416 and Q99741 |
Pubmed |
SVM Score :0.0 |
| PKA was not required for the assembly of ORC 2 , Cdc 6 and MCM 3 onto chromatin . ^^^ |
|
| Interacting proteins: Q13416 and Q99741 |
Pubmed |
SVM Score :0.0 |
| In Xenopus egg extract , the proteins Orc 1 , Orc 2 , Cdc 6 , and Mcm 4 are underphosphorylated in interphase and hyperphosphorylated in metaphase extract . ^^^ |
|
| Interacting proteins: Q13416 and Q99741 |
Pubmed |
SVM Score :0.0 |
| However , this absence of chromatin bound Cdc 6 and MCM proteins from quiescent cells appears not to be due to the absence of ORC subunits as murine homologues of Orc 1 and Orc 2 remain chromatin bound in quiescent cells . ^^^ |
|
| Interacting proteins: Q13416 and Q99741 |
Pubmed |
SVM Score :0.0 |
| In particular CDC 6 was found to bind strongly to ORC 1 and ORC 2 , and to MCM 7 proteins . ^^^ |
|
| Interacting proteins: Q13416 and Q99741 |
Pubmed |
SVM Score :0.0 |
| In G ( 1 ) , the pre replicative complex contains CDC 6 , MCM 3 , ORC 1 and ORC 2 proteins ; of these , the post replicative complex in S phase contains only ORC 2 ; in M phase none of them are bound . ^^^ The precise nucleotide of binding was identified for the two ORC and the CDC 6 proteins near the start sites for leading strand synthesis ; the transition from the pre to the post replicative complex is accompanied by a 17 bp displacement of the ORC 2 protein towards the start site . . ^^^ |
|
| Interacting proteins: Q13416 and Q99741 |
Pubmed |
SVM Score :0.0 |
| Here , we sought to identify factors that associate with TR by using a TR DNA column and found that poly ( ADP ribose ) polymerase 1 ( PARP 1 ) and known replication factors , including ORC 2 , CDC 6 , and Mcm 7 , bound to TR . ^^^ |
|
| Interacting proteins: Q13416 and Q99741 |
Pubmed |
SVM Score :0.0 |
| We demonstrated the utility of this system by showing the functional importance of the ATPase domains of human Cdc 6 and Orc 1 and the dispensability of the N terminal segments of Orc 1 and Orc 2 in this assay . ^^^ |
|
| Interacting proteins: Q13416 and Q99741 |
Pubmed |
SVM Score :0.0 |
| Here we have identified a putative DNA replication origin at the INK4 / ARF locus that assembles a multiprotein complex containing Cdc 6 , Orc 2 and MCMs , and that coincides with a conserved noncoding DNA element ( regulatory domain RD ( INK4 / ARF ) ) . ^^^ |
|
| Interacting proteins: Q13416 and Q99741 |
Pubmed |
SVM Score :0.0 |
| The binding of the prereplication complex proteins Orc 1 , Orc 2 , Mcm 3 , Mcm 7 , and Cdc 6 and the novel DNA unwinding element ( DUE ) binding protein DUE B to the endogenous human c myc replicator was studied by chromatin immunoprecipitation . ^^^ Cdc 6 binding mirrored that of Orc 2 in G ( 1 ) arrested cells but decreased in asynchronous or M phase cells . ^^^ |
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| Interacting proteins: Q13416 and Q99741 |
Pubmed |
SVM Score :0.0 |
| Using the yeast two hybrid system and immunoprecipitation , we report here that murine HP1alpha interacts with the preRC proteins ORC 1 , ORC 2 and CDC 6 . ^^^ Immunofluorescence staining and EGFP / DsRed fusion proteins revealed a colocalization of HP1alpha with ORC 1 , ORC 2 and CDC 6 in heterochromatin , supporting the notion that ORC and probably CDC 6 play an important role in murine HP1alpha function . ^^^ |
|
| Interacting proteins: Q13416 and Q99741 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13416 and Q99741 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13416 and Q99741 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13416 and Q99741 |
Pubmed |
SVM Score :0.0 |
| NA |
|