| Interacting proteins: Q99741 and P06493 |
Pubmed |
SVM Score :0.0 |
| In contrast , synthetic oligonucleotides derived from the CDC 2 , CDC 6 , and CDC 21 genes , which are expressed with the same timing as POL 1 , bind purified protein efficiently . . ^^^ |
|
| Interacting proteins: Q99741 and P06493 |
Pubmed |
SVM Score :0.0 |
| We show , using cdc 2 , cdc 6 , cdc 7 , cdc 8 , cdc 17 ( 38 degrees C ) , and cdc 21 ( also named tmp 1 ) mutants , that cells arrested in S phase complete DNA synthesis but can not complete nuclear division if protein synthesis is inhibited . ^^^ |
|
| Interacting proteins: Q99741 and P06493 |
Pubmed |
SVM Score :0.0 |
| This hypothesis is supported by our genetic experiments which show that overexpression of RAD 24 strongly reduces the growth rate of yeast strains that are defective in the DNA replication / repair proteins Rfc1p ( cdc 44 ) , DNA pol alpha ( cdc 17 ) and DNA pol delta ( cdc 2 ) but has much weaker effects on cdc 6 , cdc 9 , cdc 15 and CDC 4 strains . ^^^ |
|
| Interacting proteins: Q99741 and P06493 |
Pubmed |
SVM Score :0.0 |
| The Cdc 6 protein interacts in vivo with Cdc 2 kinase complexes . ^^^ |
|
| Interacting proteins: Q99741 and P06493 |
Pubmed |
SVM Score :0.0 |
| In G ( 2 ) / M phase cells , the level of the bound CDC 6 was still maintained , which was hyperphosphorylated by CDC 2 kinase . ^^^ |
|
| Interacting proteins: Q99741 and P06493 |
Pubmed |
SVM Score :0.0 |
| We have been able to identify a number of genes , including B myb , cyclin A , cdc 2 , cdc 6 , and DHFR , whose expression is dependent on the presence of E2F3 but not E2F1 . ^^^ |
|
| Interacting proteins: Q99741 and P06493 |
Pubmed |
SVM Score :0.0 |
| To confirm that the sequence surrounding serine 1237 was responsible for the differential regulation by Cdk 1 and Cdk 2 , we replaced 4 amino acids flanking the phosphorylation site to mimic a known Cdk 2 phosphorylation site present in the Cdc 6 protein . ^^^ Both cyclin A / Cdk2 and Cdk 1 efficiently phosphorylated the CDP / Cux ( Cdc 6 ) mutant and inhibited its DNA binding activity . ^^^ |
|
| Interacting proteins: Q99741 and P06493 |
Pubmed |
SVM Score :0.0 |
| Many genes whose expression is regulated by E2F family transcription factors , including CDK 2 , CCNE 1 , CDC 6 , CDC 2 , MCM 2 , were significantly down regulated at 24 hr post IR . ^^^ |
|
| Interacting proteins: Q99741 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99741 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99741 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99741 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99741 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99741 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99741 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99741 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|