Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: Q99732 and P46934	Pubmed	SVM Score :0.7411306
To bring insights into the biochemical function of human SIMPLE , we confirmed that human SIMPLE interacts with NEDD 4 and also report a novel interaction with tumor susceptibility gene 101 ( TSG 101 ) , a class E vacuolar sorting protein . 0.7411306^^^ SIMPLE interacts with NEDD 4 and TSG 101 : evidence for a role in lysosomal sorting and implications for Charcot Marie Tooth disease . 0.65076655^^^
Interacting proteins: Q99732 and P46934	Pubmed	SVM Score :0.0
Bioinformatics analyses and other observations of SIMPLE suggest that 1 ) it could be a member of the RING finger motif containing subfamily of E 3 ubiquitin ligases that are associated with the ubiquitin mediated proteasome processing pathway , 2 ) it could interact through its PPXY motifs with a WW domain containing protein , for instance with NEDD 4 , an E 3 ubiquitin ligase , and 3 ) it could interact through the PSAP motif with TSG 10 , a protein associated with endosomal multivesicular protein sorting . ^^^ Thus the potential E 3 ubiquitin ligase activity of SIMPLE , alteration in its interactions with NEDD 4 or TSG 101 , or changes in its properties as a clathrin coat adaptor may underlie the pathogenesis of Charcot Marie Tooth disease . . ^^^