| Interacting proteins: Q99717 and Q9HCE7 |
Pubmed |
SVM Score :0.0 |
| Smurf 1 facilitates myogenic differentiation and antagonizes the bone morphogenetic protein 2 induced osteoblast conversion by targeting Smad 5 for degradation . ^^^ Consistent with an inhibitory role in the BMP signaling pathway , the elevated Smurf 1 markedly reduces the level of endogenous Smad 5 , whereas it leaves unaltered that of Smad 2 , Smad 3 , and Smad 7 , which are components of the TGF beta pathway . ^^^ Adding back Smad 5 from a different source to the Smurf 1 overexpressing cells restores the BMP mediated osteoblast conversion . ^^^ |
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| Interacting proteins: Q99717 and Q9HCE7 |
Pubmed |
SVM Score :0.0 |
| Overexpression of Smurf 1 negatively regulates mouse embryonic lung branching morphogenesis by specifically reducing Smad 1 and Smad 5 proteins . ^^^ Further studies found that overexpression of Smurf 1 reduced BMP specific Smad 1 and Smad 5 , but not Smad 8 , protein levels . ^^^ Thus overexpression of Smurf 1 specifically promotes Smad 1 and Smad 5 ubiquitination and degradation in embryonic lung epithelium , thereby modulating the effects of BMP 4 on embryonic lung growth . . ^^^ |
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| Interacting proteins: Q99717 and Q9HCE7 |
Pubmed |
SVM Score :0.0 |
| In the region of LMP responsible for bone formation , there is a motif that directly interacts with the Smurf 1 WW2 domain and can effectively compete with Smad 1 and Smad 5 for binding . ^^^ |
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| Interacting proteins: Q99717 and Q9HCE7 |
Pubmed |
SVM Score :0.0 |
| NA |
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