| Interacting proteins: Q99717 and Q13485 |
Pubmed |
SVM Score :0.0 |
| Smad 5 homologs Smad 2 and DPC 4 have recently been linked to human cancer . ^^^ RT PCR sequencing analysis of the HL 60 Smad5 remaining allele ruled out the functional inactivation of the gene analogous to that occurring in the Smad 5 homologs DPC 4 and Smad 2 in cases of pancreatic and colorectal cancers . ^^^ |
|
| Interacting proteins: Q99717 and Q13485 |
Pubmed |
SVM Score :0.0 |
| C2C12 cells expressed Smad 1 , Smad 2 , Smad 4 , and Smad 5 mRNAs , and expression levels were not altered by treatment with BMP 2 or TGF beta 1 . ^^^ |
|
| Interacting proteins: Q99717 and Q13485 |
Pubmed |
SVM Score :0.0 |
| Smad 1 , Smad 2 , Smad 3 and Smad 5 are ligand specific : Smadl and Smad 5 transduce signals from bone morphogenetic proteins , and Smad 2 and Smad 3 mediate signalling by TGF beta and activin , whereas Smad 4 acts as a common signalling component . ^^^ |
|
| Interacting proteins: Q99717 and Q13485 |
Pubmed |
SVM Score :0.0 |
| Smad 5 and DPC 4 are key molecules in mediating BMP 2 induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12 . ^^^ Following phosphorylation , Smad 5 bound to DPC 4 , another Smad family member , and the complex was translocated to the nucleus . ^^^ Overexpression of point mutated Smad 5 ( G419S ) or a C terminal deletion mutant DPC 4 ( DPC 4 delta C ) blocked the induction of alkaline phosphatase activity , osteocalcin production , and Smad 5 DPC4 signaling cascades upon BMP 2 treatment in C2C12 cells . ^^^ |
|
| Interacting proteins: Q99717 and Q13485 |
Pubmed |
SVM Score :0.0 |
| In ROB C 26 cells , which express Smad 2 , Smad 3 , Smad 4 , and Smad 5 , OP 1 was found to stimulate the phosphorylation of Smad 5 . ^^^ |
|
| Interacting proteins: Q99717 and Q13485 |
Pubmed |
SVM Score :0.0 |
| The bone morphogenetic protein receptors , Types 1 and 2 , bind bone morphogenetic proteins and act in collaboration to transduce the phosphorylation of Smad 1 and Smad 5 , which enter the nucleus in partnership with Smad 4 to initiate bone morphogenetic protein responses including fracture healing . ^^^ |
|
| Interacting proteins: Q99717 and Q13485 |
Pubmed |
SVM Score :0.0 |
| Despite the expression of Smad 5 from gastrulation onwards , and in contrast to knockouts of Smad 2 and Smad 4 , Smad 5 only becomes essential later in extraembryonic and embryonic development . . ^^^ |
|
| Interacting proteins: Q99717 and Q13485 |
Pubmed |
SVM Score :0.0 |
| Smad 2 , Smad 4 , Smad 5 , Smad 6 and Smad 7 were not identified in eccrine sweat gland epithelia . ^^^ |
|
| Interacting proteins: Q99717 and Q13485 |
Pubmed |
SVM Score :0.0 |
| Other members of the SMAD family are excellent candidates for JPS , especially SMAD 2 ( which , like SMAD 4 , is mutated somatically in colorectal cancers ) , SMAD 3 ( which causes colorectal cancer when `` knocked out ' ' in mice ) , SMAD 5 , and SMAD 1 . ^^^ METHODS : SMAD 1 , SMAD 2 , SMAD 3 , and SMAD 5 were screened for germline mutations in 30 patients with JPS and without SMAD 4 mutations . ^^^ |
|
| Interacting proteins: Q99717 and Q13485 |
Pubmed |
SVM Score :0.0 |
| These experiments have shown that Smad 2 and Smad 4 are needed for gastrulation , Smad 5 for angiogenesis , and Smad 3 for establishment of the mucosal immune response and proper development of the skeleton . ^^^ |
|
| Interacting proteins: Q99717 and Q13485 |
Pubmed |
SVM Score :0.0 |
| Yeast 2 hybrid interaction assays reveal the lack of physical interactions between SMAD5beta and SMAD 5 or SMAD 4 . ^^^ |
|
| Interacting proteins: Q99717 and Q13485 |
Pubmed |
SVM Score :0.0 |
| Lefty did not induce Smad 2 or Smad 5 phosphorylation , Smad2 / Smad4 heterodimerization , or nuclear translocation of Smad 2 or Smad 4 , but activated the MAPK pathway in a time and dose dependent fashion . ^^^ |
|
| Interacting proteins: Q99717 and Q13485 |
Pubmed |
SVM Score :0.0 |
| We further used the Smad 7 promoter sequence that contains a Smad binding element ( SBE ) , GTCTAGAC to determine how mutations in each nucleotide in the SBE affects the binding with Smad 5 , compared with the binding with Smad 1 , Smad 2 , Smad 3 , Smad 4 , and Smad 8 . ^^^ Interestingly , Smad 5 , but not Smad 1 and Smad 8 , was able to bind the SBE , at a level similar to the binding by Smad 3 and Smad 4 . ^^^ However , mutations at the SBE had different effect on the binding with Smad 5 , compared to that with Smad 3 and Smad 4 . ^^^ |
|
| Interacting proteins: Q99717 and Q13485 |
Pubmed |
SVM Score :0.0 |
| At day 10 , Smad 6 increased dramatically , Smad 2 , Smad 3 , and Smad 4 remained elevated while Smad 1 and Smad 5 decreased in the fracture callus . ^^^ |
|
| Interacting proteins: Q99717 and Q13485 |
Pubmed |
SVM Score :0.0 |
| We show here that hGL cells express mRNAs for distinct serine / threonine kinase receptors ( BMP RIA and BMP RII ) and Smad signaling proteins ( Smad 1 , Smad 4 , and Smad 5 ) involved in the mediation of cellular effects of BMPs . ^^^ |
|
| Interacting proteins: Q99717 and Q13485 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : The intracellular signaling events of the bone morphogenetic proteins ( BMPs ) involve the R Smad family members Smad 1 , Smad 5 , Smad 8 and the Co Smad , Smad 4 . ^^^ |
|
| Interacting proteins: Q99717 and Q13485 |
Pubmed |
SVM Score :0.0 |
| In rat SMC , Smad 1 , Smad 2 , Smad 3 , Smad 4 and Smad 5 were detected by immunoprecipitation . ^^^ |
|
| Interacting proteins: Q99717 and Q13485 |
Pubmed |
SVM Score :0.0 |
| We further determined that Smad 1 or Smad 5 , but not Smad 8 , synergized with Smad 4 in the transactivation of the type 2 collagen promoter in chondroprogenitor cells . ^^^ |
|
| Interacting proteins: Q99717 and Q13485 |
Pubmed |
SVM Score :0.0 |
| Smads could be divided into receptor regulated Smads ( R Smads : Smad 1 , Smad 2 , Smad 3 , Smad 5 , Smad 8 and Smad 9 ) , common mediator Smad ( co Smad : Smad 4 ) , and inhibitory Smads ( 1 Smads : Smad 6 and Smad 7 ) . ^^^ |
|
| Interacting proteins: Q99717 and Q13485 |
Pubmed |
SVM Score :0.0 |
| Interaction with Smad 4 is indispensable for suppression of BMP signaling by c Ski . c Ski is a transcriptional corepressor that interacts strongly with Smad 2 , Smad 3 , and Smad 4 but only weakly with Smad 1 and Smad 5 . ^^^ |
|
| Interacting proteins: Q99717 and Q13485 |
Pubmed |
SVM Score :0.0 |
| USA 94 , 12938 12943 ; Nishimura R . et al . ( 1998 ) `` Smad 5 and DPC 4 are key molecules in mediating BMP 2 induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12 ' ' , J . ^^^ |
|
| Interacting proteins: Q99717 and Q13485 |
Pubmed |
SVM Score :0.0 |
| Using cultured basal forebrain cells derived from embryonic day ( E ) 14 mice , we show that BMP 9 causes phosphorylation of Smad 1 and Smad 5 , formation of a complex of Smad 4 with Samd 1 and / or Smad 5 , and translocation of these proteins into the nucleus . ^^^ |
|
| Interacting proteins: Q99717 and Q13485 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99717 and Q13485 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99717 and Q13485 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99717 and Q13485 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99717 and Q13485 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99717 and Q13485 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99717 and Q13485 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99717 and Q13485 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99717 and Q13485 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99717 and Q13485 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99717 and Q13485 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99717 and Q13485 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99717 and Q13485 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99717 and Q13485 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99717 and Q13485 |
Pubmed |
SVM Score :0.54533904 |
| Smad 1 , Smad 5 and probably MADH 6 , are activated by BMP receptors , form heteromeric complexes with Smad 4 , and translocate into the nucleus where they may activate transcription of various genes . 0.54533904^^^ |
|
| Interacting proteins: Q99717 and Q13485 |
Pubmed |
SVM Score :0.83303589 |
| Upon stimulation with BMP , Smad 1 , Smad 5 , and Smad 8 are phosphorylated by the activated BMP receptors , form a complex with Smad 4 , and translocate into the nucleus , where they regulate the expression of BMP target genes . 0.83303589^^^ |
|
| Interacting proteins: Q99717 and Q13485 |
Pubmed |
SVM Score :0.83303589 |
| Upon stimulation with BMP , Smad 1 , Smad 5 , and Smad 8 are phosphorylated by the activated BMP receptors , form a complex with Smad 4 , and translocate into the nucleus , where they regulate the expression of BMP target genes . 0.83303589^^^ |
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