| Interacting proteins: P22004 and Q99717 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22004 and Q99717 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22004 and Q99717 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22004 and Q99717 |
Pubmed |
SVM Score :0.0 |
| Among the receptor regulated Smads activated by BMP receptors , BMP 6 strongly induced phosphorylation and nuclear accumulation of Smad 5 , and less efficiently those of Smad 1 . ^^^ These findings indicate that in the process of differentiation to osteoblasts , BMP 6 binds to ALK 2 as well as other type 1 receptors , and transduces signals mainly through Smad 5 and possibly through Smad1 . . ^^^ |
|
| Interacting proteins: P22004 and Q99717 |
Pubmed |
SVM Score :0.0 |
| BMP 6 dramatically enhanced alkaline phosphatase activity induced by Smad 1 or Smad 5 , probably because of the nuclear translocation of R Smads triggered by the ligand . ^^^ |
|
| Interacting proteins: P22004 and Q99717 |
Pubmed |
SVM Score :0.0 |
| BMPER is a secreted protein that directly interacts with BMP 2 , BMP 4 , and BMP 6 and antagonizes BMP 4 dependent Smad 5 activation . ^^^ |
|
| Interacting proteins: P22004 and Q99717 |
Pubmed |
SVM Score :0.0 |
| In contrast , Smad 1 , Smad 5 , BMP 2 , and BMP 6 expression was increased , suggesting a shift from TGF beta toward BMP signaling . ^^^ |
|
| Interacting proteins: P22004 and Q99717 |
Pubmed |
SVM Score :0.0 |
| BMP 6 increased in vivo the bone expression of Acvr 1 , Bmpr1b , Smad 5 , alkaline phosphatase , and collagen type 1 and decreased expression of Bmp 3 and BMP antagonists , chordin and cerberus . ^^^ |
|