| Interacting proteins: Q99650 and P23458 |
Pubmed |
SVM Score :0.0 |
| We further show that the Janus kinases Jak 1 and Jak 2 constitutively associated with receptor constructs containing the cytoplasmic part of LIFR , OSMR , or gp 130 , respectively . ^^^ |
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| Interacting proteins: Q99650 and P23458 |
Pubmed |
SVM Score :0.0 |
| Upon heterologous expression of the OSMR in several cell lines , we observed that its surface expression was significantly enhanced by coexpression of the Janus kinases Jak 1 , Jak 2 , and Tyk 2 but not Jak 3 . ^^^ Chimeric receptors consisting of the extracellular region of the interleukin 5 receptor beta chain and the transmembrane and intracellular part of the OSMR were similarly up regulated on the plasma membrane when Jak 1 was coexpressed . ^^^ The overall expression level of these constructs did not change significantly , but Jak 1 coexpression increased the amount of endoglycosidase H resistant , fully processed OSMR chimeras . ^^^ Finally we demonstrate that in Jak 1 deficient cells , the endogenous OSMR is significantly down regulated , an effect that can be reversed by transient expression of Jak 1 in these cells . . ^^^ |
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| Interacting proteins: Q99650 and P23458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P23458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P23458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P23458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P23458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P23458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P23458 |
Pubmed |
SVM Score :0.0 |
| NA |
|