| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| Leukemia inhibitory factor ( LIF ) , cardiotrophin 1 , ciliary neurotrophic factor , and oncostatin M ( OSM ) lead to heterodimerization of LIF receptor ( LIFR ) or the OSM specific receptor ( OSMR ) with glycoprotein ( gp ) 130 , the common receptor subunit for IL 6 type cytokines . ^^^ |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| Its mechanism of action is via specific binding to gp 130 and either the leukaemia inhibitory factor receptor ( LIFR ) or oncostatin M receptor ( OSMR ) systems at the cell surface to form an active signalling complex . ^^^ |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| The oncostatin M receptor ( OSMR ) is part of a heterodimeric receptor complex that mediates signal transduction of the pleiotropic cytokine OSM via a signaling pathway involving Janus kinases ( Jaks ) and transcription factors of the signal transducers and activators of transcription ( STAT ) family . ^^^ |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M can activate two related receptors , one consisting of a low affinity LIF receptor subunit , LIFR beta , which forms a heterocomplex with the gp 130 signal transducing protein and can recognize both oncostatin M and LIF , and a second heterocomplex consisting of a subunit that specifically recognizes oncostatin M , OSMR beta , and the gp 130 protein . ^^^ Recombinant human Oncostatin M ( rhOSM ) can induce the transient tyrosine 705 phosphorylation of STAT 3 in serum starved LIFR beta / OSMR beta expressing ovarian carcinoma cell lines , but does not alter cell growth and effects only a modest increase in the apoptotic rate in these cultured cells . ^^^ |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) is a member of the interleukin 6 family of cytokines , and we have reported previously that the murine OSM receptor beta subunit ( OSMR ) was expressed in some neurons in the adult trigeminal and dorsal root ganglia ( DRGs ) and in the perineonatal hypoglossal nucleus . ^^^ |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| The effects of murine oncostatin M ( mOSM ) are specifically mediated by the heterodimeric oncostatin M receptor ( OSMR ) / gp130 receptor complex . ^^^ |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| The goldfish LIFR phylogenetically groups with the other identified LIFRs from human , mouse , rat and chicken , and it appears to be ancestral to the divergence of the oncostatin M receptor ( OSMR ) . ^^^ |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| Leukemia inhibitory factor ( LIF ) and its receptor ( LIFR ) are `` twins ' ' of Oncostatin M ( OSM ) and OSMR , respectively , likely having arisen through gene duplications . ^^^ |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| In the present study , we showed that OSM mRNA was highly expressed in the inflamed skin during acute inflammation induced by complete Freund ' s adjuvant ( CFA ) , while the expression of oncostatin M receptor ( OSMR ) did not change in the ipsilateral DRG . ^^^ |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| The oncostatin M receptor ( OSMR ) is part of receptor complexes for oncostatin M and interleukin 31 . ^^^ |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| In the present study , we analyzed the effect of SOCS 3 on signal transduction by the proinflammatory cytokine oncostatin M ( OSM ) , which signals through a receptor complex of gp 130 and the OSM receptor ( OSMR ) . ^^^ |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| To define the specificity of the signal transduction by the LIF / OSM receptor ( a heterodimer of gp 130 and LIF receptor ( LIFR ) ) and the OSM specific receptor ( a heterodimer of gp 130 and OSM receptor ( OSMR ) ) , we reconstituted the receptor function by transfection into receptor negative Hep3B hepatoma cells . ^^^ The 36 residue carboxyl terminal region containing the distal box 3 sequence motif of OSMR is required for signal transduction by the OSM specific receptor . ^^^ |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| Since LIF together with LIFRalpha appear to form a more stable complex with gp 130 than OSM with gp 130 and OSMRbeta , co activation of LIFR and OSMR resulted in a predominant LIF like response . ^^^ |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| Using neutralizing antibodies to gp 130 , the OSM receptor ( OSMR ) , and the leukemia inhibitory factor receptor ( LIFR ) , we document that OSM exclusively uses the OSMR / gp 130 heterodimer in signaling events , rather than the LIFR / gp 130 heterodimer . ^^^ |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| Shc is recruited to the OSM receptor ( OSMR ) , but not to gp 130 . ^^^ |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| Using RT PCR we detected transcripts of the receptor components involved in OSM signaling , gp 130 , OSM receptor ( OSMR ) beta , and leukemia inhibitory factor receptor ( LIFR ) , in HCEC . ^^^ |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| Expression of CT 1 and OSM increased with culture time that is , with osteoblast differentiation whereas the specific receptor for OSM ( OSMR ) was highly expressed at early timepoints and either plateaued or decreased thereafter . ^^^ Continuous treatment with Dex ( 10 ( 8 ) mol / L ) inhibited the endogenous production of IL 6 , LIF , OSM , IL 11R , and OSMR , but had no detectable effect on the expression of IL 11 , CT 1 , CNTF , CNTFR , LIFR , or gp 130 . ^^^ |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| To uncover roles of OSM , we have generated mutant mice deficient in the OSM specific receptor beta subunit ( OSMR ) . ^^^ Consistent with this , progenitors of erythroid and megakaryocyte lineages were reduced in OSMR / bone marrow ( BM ) , suggesting that OSM is required for the maintenance of erythroid and megakaryocyte progenitor pools in BM . ^^^ The OSMR / mice , engrafted with wild type BM cells , failed to produce erythrocytic and megakaryocytic progenitors to the levels in wild type mice , indicating that OSM affects hematopoietic microenvironments . ^^^ |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| Mice deficient in the OSM receptor ( OSMR ( / ) ) showed impaired liver regeneration with persistent parenchymal necrosis after carbon tetrachloride ( CCl ( 4 ) ) exposure . ^^^ The activation of STAT 3 and expression of immediate early genes and cyclins were decreased in OSMR ( / ) liver , indicating that OSM signaling is required for hepatocyte proliferation and tissue remodeling during liver regeneration . ^^^ |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| In the adult central nervous system ( CNS ) , OSM receptor ( OSMR ) beta was observed in meningeal cells of pia mater , epithelial cells of the choroid plexus and olfactory astrocyte like glia surrounding the glomeruli of the olfactory bulb . ^^^ |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| Here , we show that liver OSM expression increases in mice fed a CDE diet and CDE derived oval cell isolates express OSM and its receptor ( OSMR ) . ^^^ |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| These data support the role of OSM in eosinophil accumulation into lung tissue through eotaxin 1 and VCAM 1 expression and the notion that OSM is able to induce unique signal transduction events through its receptor complex of OSMR beta chain and gp130 . . ^^^ |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and Q99650 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| To define the specificity of the signal transduction by the LIF / OSM receptor ( a heterodimer of gp 130 and LIF receptor ( LIFR ) ) and the OSM specific receptor ( a heterodimer of gp 130 and OSM receptor ( OSMR ) ) , we reconstituted the receptor function by transfection into receptor negative Hep3B hepatoma cells . ^^^ The 36 residue carboxyl terminal region containing the distal box 3 sequence motif of OSMR is required for signal transduction by the OSM specific receptor . ^^^ |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| Leukemia inhibitory factor ( LIF ) , cardiotrophin 1 , ciliary neurotrophic factor , and oncostatin M ( OSM ) lead to heterodimerization of LIF receptor ( LIFR ) or the OSM specific receptor ( OSMR ) with glycoprotein ( gp ) 130 , the common receptor subunit for IL 6 type cytokines . ^^^ |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| Since LIF together with LIFRalpha appear to form a more stable complex with gp 130 than OSM with gp 130 and OSMRbeta , co activation of LIFR and OSMR resulted in a predominant LIF like response . ^^^ |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| Using neutralizing antibodies to gp 130 , the OSM receptor ( OSMR ) , and the leukemia inhibitory factor receptor ( LIFR ) , we document that OSM exclusively uses the OSMR / gp 130 heterodimer in signaling events , rather than the LIFR / gp 130 heterodimer . ^^^ |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| Its mechanism of action is via specific binding to gp 130 and either the leukaemia inhibitory factor receptor ( LIFR ) or oncostatin M receptor ( OSMR ) systems at the cell surface to form an active signalling complex . ^^^ |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| Shc is recruited to the OSM receptor ( OSMR ) , but not to gp 130 . ^^^ |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| Using RT PCR we detected transcripts of the receptor components involved in OSM signaling , gp 130 , OSM receptor ( OSMR ) beta , and leukemia inhibitory factor receptor ( LIFR ) , in HCEC . ^^^ |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| The oncostatin M receptor ( OSMR ) is part of a heterodimeric receptor complex that mediates signal transduction of the pleiotropic cytokine OSM via a signaling pathway involving Janus kinases ( Jaks ) and transcription factors of the signal transducers and activators of transcription ( STAT ) family . ^^^ |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M can activate two related receptors , one consisting of a low affinity LIF receptor subunit , LIFR beta , which forms a heterocomplex with the gp 130 signal transducing protein and can recognize both oncostatin M and LIF , and a second heterocomplex consisting of a subunit that specifically recognizes oncostatin M , OSMR beta , and the gp 130 protein . ^^^ Recombinant human Oncostatin M ( rhOSM ) can induce the transient tyrosine 705 phosphorylation of STAT 3 in serum starved LIFR beta / OSMR beta expressing ovarian carcinoma cell lines , but does not alter cell growth and effects only a modest increase in the apoptotic rate in these cultured cells . ^^^ |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| Expression of CT 1 and OSM increased with culture time that is , with osteoblast differentiation whereas the specific receptor for OSM ( OSMR ) was highly expressed at early timepoints and either plateaued or decreased thereafter . ^^^ Continuous treatment with Dex ( 10 ( 8 ) mol / L ) inhibited the endogenous production of IL 6 , LIF , OSM , IL 11R , and OSMR , but had no detectable effect on the expression of IL 11 , CT 1 , CNTF , CNTFR , LIFR , or gp 130 . ^^^ |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| To uncover roles of OSM , we have generated mutant mice deficient in the OSM specific receptor beta subunit ( OSMR ) . ^^^ Consistent with this , progenitors of erythroid and megakaryocyte lineages were reduced in OSMR / bone marrow ( BM ) , suggesting that OSM is required for the maintenance of erythroid and megakaryocyte progenitor pools in BM . ^^^ The OSMR / mice , engrafted with wild type BM cells , failed to produce erythrocytic and megakaryocytic progenitors to the levels in wild type mice , indicating that OSM affects hematopoietic microenvironments . ^^^ |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) is a member of the interleukin 6 family of cytokines , and we have reported previously that the murine OSM receptor beta subunit ( OSMR ) was expressed in some neurons in the adult trigeminal and dorsal root ganglia ( DRGs ) and in the perineonatal hypoglossal nucleus . ^^^ Oncostatin M ( OSM ) is a member of the interleukin 6 family of cytokines , and we have reported previously that the murine OSM receptor beta subunit ( OSMR ) was expressed in some neurons in the adult trigeminal and dorsal root ganglia ( DRGs ) and in the perineonatal hypoglossal nucleus . ^^^ In the present study , we investigated the development of OSMR positive neurons of DRGs in OSM deficient mice . ^^^ |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| Mice deficient in the OSM receptor ( OSMR ( / ) ) showed impaired liver regeneration with persistent parenchymal necrosis after carbon tetrachloride ( CCl ( 4 ) ) exposure . ^^^ The activation of STAT 3 and expression of immediate early genes and cyclins were decreased in OSMR ( / ) liver , indicating that OSM signaling is required for hepatocyte proliferation and tissue remodeling during liver regeneration . ^^^ |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| The effects of murine oncostatin M ( mOSM ) are specifically mediated by the heterodimeric oncostatin M receptor ( OSMR ) / gp130 receptor complex . ^^^ |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| The goldfish LIFR phylogenetically groups with the other identified LIFRs from human , mouse , rat and chicken , and it appears to be ancestral to the divergence of the oncostatin M receptor ( OSMR ) . ^^^ |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| Leukemia inhibitory factor ( LIF ) and its receptor ( LIFR ) are `` twins ' ' of Oncostatin M ( OSM ) and OSMR , respectively , likely having arisen through gene duplications . ^^^ Using a dominant negative LIF mutant ( hLIF 05 ) , we showed that in RC cell cultures mouse OSM ( mOSM ) activates exclusively glycoprotein 130 ( gp 130 ) / OSMR . ^^^ |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| In the adult central nervous system ( CNS ) , OSM receptor ( OSMR ) beta was observed in meningeal cells of pia mater , epithelial cells of the choroid plexus and olfactory astrocyte like glia surrounding the glomeruli of the olfactory bulb . ^^^ |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| Here , we show that liver OSM expression increases in mice fed a CDE diet and CDE derived oval cell isolates express OSM and its receptor ( OSMR ) . ^^^ |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| The oncostatin M receptor ( OSMR ) is part of receptor complexes for oncostatin M and interleukin 31 . ^^^ |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| In the present study , we analyzed the effect of SOCS 3 on signal transduction by the proinflammatory cytokine oncostatin M ( OSM ) , which signals through a receptor complex of gp 130 and the OSM receptor ( OSMR ) . ^^^ |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| These data support the role of OSM in eosinophil accumulation into lung tissue through eotaxin 1 and VCAM 1 expression and the notion that OSM is able to induce unique signal transduction events through its receptor complex of OSMR beta chain and gp130 . . ^^^ |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| In the present study , we showed that OSM mRNA was highly expressed in the inflamed skin during acute inflammation induced by complete Freund ' s adjuvant ( CFA ) , while the expression of oncostatin M receptor ( OSMR ) did not change in the ipsilateral DRG . ^^^ |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P13725 |
Pubmed |
SVM Score :0.0 |
| NA |
|