| Interacting proteins: O43447 and Q99633 |
Pubmed |
SVM Score :0.0 |
| The splicing factors hPrp 18 and hPrp 4 have a short region of homology that defines a high affinity binding site for USA CyP in each protein . ^^^ USA CyP forms separate , stable complexes with hPrp 18 and hPrp 4 in which the active site of the cyclophilin is exposed . ^^^ The cyclophilin inhibitor cyclosporin A slows pre mRNA splicing in vitro , and we show that its inhibition of the second step of splicing is caused by blocking the action of USA CyP within its complex with hPrp 18 . ^^^ Our results lead to a model in which USA CyP is carried into the spliceosome in complexes with hPrp 4 and hPrp 18 , and USA CyP acts during splicing within these complexes . ^^^ |
|
| Interacting proteins: O43447 and Q99633 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99633 and O43447 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99633 and O43447 |
Pubmed |
SVM Score :0.0 |
| The splicing factors hPrp 18 and hPrp 4 have a short region of homology that defines a high affinity binding site for USA CyP in each protein . ^^^ USA CyP forms separate , stable complexes with hPrp 18 and hPrp 4 in which the active site of the cyclophilin is exposed . ^^^ The cyclophilin inhibitor cyclosporin A slows pre mRNA splicing in vitro , and we show that its inhibition of the second step of splicing is caused by blocking the action of USA CyP within its complex with hPrp 18 . ^^^ Our results lead to a model in which USA CyP is carried into the spliceosome in complexes with hPrp 4 and hPrp 18 , and USA CyP acts during splicing within these complexes . ^^^ |
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