| Interacting proteins: Q99608 and Q16254 |
Pubmed |
SVM Score :0.88813594 |
| The transcription factors E2F1 and E2F4 physically interacted with necdin via their carboxyl terminal transactivation domains , but only E2F1 abrogated necdin induced growth arrest and neurite outgrowth of neuroblastoma cells . 0.88813594^^^ |
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| Interacting proteins: Q99608 and Q16254 |
Pubmed |
SVM Score :0.0 |
| Necdin and E2F4 are modulated by rosiglitazone therapy in diabetic human adipose and muscle tissue . ^^^ The expression of cell cycle regulatory transcription factors E2F4 and the MAGE protein necdin were similarly altered in all subjects after rosiglitazone treatment . ^^^ E2F4 expression was decreased by 10 fold in muscle and 2 . 5 fold in adipose tissue ; necdin was identified in adipose tissue only and increased 1 . 8 fold after TZD treatment . ^^^ While treatment of differentiated adipocytes with rosiglitazone did not alter E2F4 or necdin , expression of both genes was significantly altered during differentiation . ^^^ These data suggest that changes in necdin and E2F4 expression after rosiglitazone exposure in humans are associated with altered adipocyte differentiation and may contribute to improved insulin sensitivity in humans treated with TZDs . . ^^^ |
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