| Interacting proteins: Q99608 and Q01094 |
Pubmed |
SVM Score :0.56398849 |
| Necdin , a postmitotic neuron specific growth suppressor , interacts with viral transforming proteins and cellular transcription factor E2F1 . 0.56398849^^^ |
|
| Interacting proteins: Q99608 and Q01094 |
Pubmed |
SVM Score :0.51854193 |
| Necdin binds to major transcription factors E2F1 and p 53 , suggesting that necdin exerts its functions through the interactions with these cell cycle regulating factors . 0.51854193^^^ |
|
| Interacting proteins: Q99608 and Q01094 |
Pubmed |
SVM Score :1.2135552 |
| The transcription factors E2F1 and E2F4 physically interacted with necdin via their carboxyl terminal transactivation domains , but only E2F1 abrogated necdin induced growth arrest and neurite outgrowth of neuroblastoma cells . 1.2135552^^^ |
|
| Interacting proteins: Q99608 and Q01094 |
Pubmed |
SVM Score :0.91238989 |
| Necdin and MAGE G 1 interacted with the transcription factor E2F1 via its transactivation domain , repressed E2F1 dependent transcription , and antagonized E2F1 induced apoptosis of N1E 115 neuroblastoma cells . 0.91238989^^^ |
|
| Interacting proteins: Q99608 and Q01094 |
Pubmed |
SVM Score :0.0 |
| Necdin , like the retinoblastoma protein , interacts with cell cycle promoting proteins such as simian virus 40 large T antigen , adenovirus E1A , and the transcription factor E2F1 . ^^^ |
|
| Interacting proteins: Q99608 and Q01094 |
Pubmed |
SVM Score :0.0 |
| The necdin gene is expressed predominantly in postmitotic neurons and encodes a growth suppressor that interacts with the transcription factors E2F1 and p 53 . ^^^ |
|
| Interacting proteins: Q99608 and Q01094 |
Pubmed |
SVM Score :0.0 |
| Necdin , a growth suppressor expressed predominantly in postmitotic neurons , interacts with viral oncoproteins and cellular transcription factors E2F1 and p 53 . ^^^ |
|
| Interacting proteins: Q99608 and Q01094 |
Pubmed |
SVM Score :0.0 |
| Since Restin was localized in cell nucleus , and its homolog member , Necdin ( neuronal growth suppressor factor ) , could interact with transcription factors p 53 and E2F1 , we proposed that Restin might also function as Necdin through interacting with some transcription factors . ^^^ |
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